Women on the liver transplantation waitlist are at increased risk of hospitalization compared to men
Women on the liver transplantation waitlist are at increased risk of hospitalization compared to men作者机构：Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of California-San FranciscoSan FranciscoCA 94143 United States Department of Gastroenterology and HepatologyAustin HealthHeidelberg 3084VictoriaAustralia Department of Medicinethe University of MelbourneMelbourne 3010VictoriaAustralia Division of HepatologyAnnette C.and Harold C.Simmons Transplant InstituteBaylor University Medical CenterDallasTX 75346United States Division of Gastroenterology and HepatologyUniversity of MichiganAnn ArborMI 48109United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2019年第25卷第8期
页 面：980-988页
核心收录：
基 金：Supported by NIA Grants for Early Medical and Surgical Subspecialists’ Transition to Aging Research(R03AG045072,Lai) NIA Paul B.Beeson Career Development Award in Aging(K23AG048337,Lai) NIDDK National Research Service Award Hepatology Training Grant(T32DK060414,Rubin)
主 题：Gender Cirrhosis Liver transplantation waitlist Hospitalization Readmission Women
摘 要：BACKGROUND Hospital admissions are common among patients with cirrhosis,but patient factors associated with hospitalization have not been well *** recent data suggesting increased liver transplant waitlist dropout among women,we hypothesized that women on the liver transplant waitlist would have increased rates of hospitalization compared with *** To evaluate the role of gender on risk of hospitalization for patients on the liver transplant waitlist,in order to help explain gender disparities in waitlist *** Patients listed for liver transplant at a single center in the United States were prospectively enrolled in the Functional Assessment in Liver Transplantation *** included in this retrospective analysis included those enrolled between March 2012 and December 2014 with at least 12 mo of follow up and without hepatocellular *** primary and secondary outcomes were hospitalization and total inpatient days within 12 mo,*** and negative binomial regression associated baseline factors with *** Of the 392 patients,41%were female,with median(interquartile range)age 58 years(52-63)and model for end-stage liver disease 18(15-22).Within 12 mo,186(47%)patients were hospitalized≥1 time;48%were readmitted,with a median of 8(4-15)inpatient *** women than men were hospitalized(54%vs 43%;P=0.03).In univariable analysis,female sex was associated with an increased risk of hospitalization[odds ratios(OR)1.6,95%confidence interval(CI)1.0-2.4;P=0.03],which remained significant on adjusted multivariable analysis(OR 1.6,95%CI:1.1-2.6;P=0.03).Female gender was also associated with an increased number of inpatient days within 12 mo in both univariable and multivariable *** Women with cirrhosis on the liver transplant waitlist have more hospitalizations and inpatient days in one year compared with men,suggesting that the experience of cirrhosis differs between men and women,despite
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