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New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

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World Journal of Experimental Medicine 2022年第1期12卷 1-15页

作者： Lívia Bitencourt Pascoal Bruna Biazon Palma Fabio Henrique Mendonça Chaim Marina Moreira de Castro Tiago Andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso raquel franco leal Inflammatory Bowel Disease Research Laboratory Colorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic Disorders School of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell Signaling School of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil

The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.

关键词： Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease

Ferric carboxymaltose for anemia in Crohn’s disease patients at a tertiary center:A retrospective observational cohort study

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World Journal of Clinical Cases 2023年第12期11卷 2740-2752页

作者： Natália Souza Nunes Siqueira Livia Bitencourt Pascoal Bruno Lima Rodrigues Marina Moreira de Castro Alan Sidnei Corrêa Martins Dante Orsetti Silva Araújo Luis Eduardo Miani Gomes Michel Gardere Camargo Maria de Lourdes Setsuko Ayrizono raquel franco leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitSchool of Medical SciencesUniversity of Campinas(Unicamp)Campinas 13083-878São PauloBrazil

BACKGROUND Although the gastrointestinal tract is the most affected by Crohn’s disease(CD),the condition triggers other consequent manifestations,and iron deficiency anemia(IDA)is one of the most ***(IV)iron replacement is currently available through several drugs,such as ferric hydroxide sucrose and ferric carboxymaltose(FCM).However,the clinical management of these conditions can be *** To elucidate the drug’s effectiveness,the present study analyzed,through medical records,the clinical and epidemiological data of a cohort of patients with active CD who received IV FCM for the IDA *** This retrospective observational study included 25 patients with active CD,severe anemia,and refractory to previous conventional *** were evaluated two times:During the last treatment with ferric hydroxide sucrose and treatment with *** After treatment with FCM,parameters of IDA assessment significantly improved,serum hemoglobin(Hb)levels increased in 93%of patients(Pleal and colonic CD and use of biologics and a positive association with patients who developed CD later in life after the age of 40(A3)and with a stenosing(B2)and fistulizing(B3)*** values of Hb and hematocrit after ferric hydroxide sucrose treatment remained similar to those found before *** This study demonstrated that FCM is an important therapeutic strategy for treating IDA in CD patients,achieving satisfactory results in refractory cases.

关键词： Ferric carboxymaltose Iron deficiency anemia Crohn’s disease Inflammatory bowel disease Anemia Clinical management

Assessment of disease activity in inflammatory bowel diseases:Non-invasive biomarkers and endoscopic scores

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World Journal of Gastrointestinal Endoscopy 2020年第12期12卷 504-520页

作者： Bruno Lima Rodrigues Marcia Carolina Mazzaro Cristiane Kibune Nagasako Maria de Lourdes SetsukoAyrizono Joao Jose Fagundes raquel franco leal Inflammatory Bowel Disease Research Laboratory GastrocenterColorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878São PauloBrazil Department of Gastroenterology GastrocenterSchool of Medical SciencesUniversity of Campinas(UNICAMP)Campinas 13083-878Sao PauloBrazil

Inflammatory bowel diseases(IBD)comprise two major forms:Crohn’s disease and ulcerative *** diagnosis of IBD is based on clinical symptoms combined with results found in endoscopic and radiological *** addition,the discovery of biomarkers has significantly improved the diagnosis and management of *** potential genetic,serological,fecal,microbial,histological and immunological biomarkers have been proposed for IBD,and they have been evaluated for clinical routine and clinical ***,especially with biopsy collection,has been considered the standard method to diagnose IBD and to assess clinical activity of the disease,but it is limited to the colon and terminal ileum and is considered *** this reason,non-invasive biomarkers are necessary for this type of chronic inflammatory disease,which affects mostly young individuals,as they are expected to have a long follow-up.

关键词： Inflammatory bowel diseases Biomarkers Endoscopic scores Crohn's disease Ulcerative colitis Inflammation

Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta Zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Effect of psychological stress on gastric motility assessed by electrical bio-impedance

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World Journal of Gastroenterology 2012年第36期18卷 5027-5033页

作者： María raquel Huerta-franco Miguel Vargas-Luna Juana Berenice Montes-Frausto Ismael Morales-Mata Lorena Ramirez-Padilla Department of Applied Sciences to Work Health Science DivisionUniversity of Guanajuato37320 LeonGuanajuatoMexico Department of Physical Engineering Science and Engineering DivisionUniversity of Guanajuato37150 LeonGuanajuatoMexico

AIM:To evaluate gastric motility using electrical bioimpedance(EBI) and gastric changes as a result of stress induced by psychological ***:A group of 57 healthy women,aged 40-60 years,was recruited,and a clinical history and physical examination were *** women were free from severe anxiety,chronic or acute stress,severe depression,mental diseases and conditions that affect gastric *** women were evaluated under fasting conditions,and using a four-electrode configuration,the gastric signals were obtained through a BIOPAC MP-150 *** volunteers were evaluated using the following paradigm:basal state,recording during the Stroop Test,intermediate resting period,recording during the Raven Test,and a final resting *** analyzed the relative areas of the frequency spectrum:A1(1-2 cpm),A2(2-4 cpm),A3(4-8 cpm),and A4(8-12 cpm),as well as the median of area A2 + *** data were analyzed by an autoregressive method using a Butterworth filter with MatLab and *** of variance(ANOVA) and Friedman ANOVA(for nonparametric variables) were performed;in addition,pairs of groups were compared using the T dependent and Wilcoxon T ***:The results of the main values of area A2 were not significantly different comparing the five steps of the experimental ***,there was a tendency of this A2 region to decrease during the stress tests,with recuperation at the final resting *** an extended gastric region was considered(1-4 cpm),significant differences with the psychological stress tests were present(F = 3.85,P = 0.005).The A3 region also showed significant changes when the stress psychological tests were administered(F = 7.25,P < 0.001).These differences were influenced by the changes in the adjacent gastric region of *** parameter that we proposed in previous studies for the evaluation of gastric motility by electrical bio-impedance(EBI) was the median of the area under the region from 2 to 8 cpm(A2 + A3)

关键词： Psychological stress Bio-impedance Gas-tric motility

Adsorption of Methylene Blue on magnesium silicate: Kinetics, equilibria and comparison with other adsorbents

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Journal of Environmental Sciences 2010年第3期22卷 467-473页

作者： franco Ferrero Department of Materials Science and Chemical Engineering Polytechnic of Torino Corso Duca degli Abruzzi 24 I10129 Torino Italy

Batch adsorption from aqueous solutions in a slightly basic medium of Methylene Blue, up to 2500 mg/L, onto synthetic magnesium silicate （Florisil） of three particle size ranges （mean diameters of 112, 200 and 425 μm） was compared to the corresponding adsorption onto activated carbon and Amberlite XAD-2. The best fit of the kinetic results was achieved by a pseudo second-order equation. The equilibrium data were found to be well represented by the Langmuir isotherm equation. Amberlite XAD-2, an unspecific adsorbent capable of adsorbing exclusively through a surface effect, exhibited a poor dye uptake, confirming that the adsorption mechanism on Florisil was due to electrostatic attraction and ion exchange. Moreover, the comparison between Florisil and the other adsorbents was performed on the basis of the evaluation of the surface area and pore volume occupied by the adsorbed dye.

关键词： dye adsorption magnesium silicate Florisil adsorption kinetics adsorption isotherms

Subaerial hot springs and near-surface hydrothermal mineral systems past and present,and possible extraterrestrial analogues

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Geoscience Frontiers 2020年第5期11卷 1549-1569页

作者： franco Pirajno Centre for Exploration Targeting(CET) The University of Western Australia35Stirling HighwayCrawleyWA6009Australia

The principal features,geotectonic settings and association with near-surface hydrothermal mineral systems of ancient and present subaerial hot springs,fumaroles and geysers are herein *** and geysers usually occur in volcanic craters and are in most cases,part and parcel of hot spring *** hot springs are characterised by siliceous-and carbonate-rich chemical sediments,such as sinters and travertines,*** are commonly enriched in various metalliferous *** springs surface discharges are also characterised by pools,which exhibit bright colours due to the presence of ***-day examples discussed in this paper,include the fumaroles and hot springs of the White Island volcano(New Zealand),the world-renowned Yellowstone caldera(USA)and the Afar region of the East African Rift *** Afar triangle,in the northern part of East African Rift System,provides a good example of hot springs associated with evaporative *** Tuli-Sabi-Lebombo triple junction rifts were formed during the^180 Ma Karoo igneous event in southern Africa,of which the Tuli arm is the failed rift(aulacogen),as is the Afar *** Tuli rift is effectively an unusual,if not unique,tectono-thermal setting,because it comprises Karoo-age hot springs systems and associated vein stockworks and breccias,which includes the Messina Cu deposit as well as currently active hot springs with sinter deposits probably due to post-Karoo *** pipes in ignimbrites of the Erongo Volcano-Plutonic Complex in Namibia are *** is followed by an example of banded chert rocks in the Killara Formation of the Palaeoproterozoic Capricorn Orogen(Western Australia),interpreted as hot spring chemical sediments,which also show evidence of"fossil"microbial *** paper ends with a brief overview of possible analogues of hot springs on planet Mars.

关键词： Subaerial hot springs Fumaroles Chemical sediments Hydrothermal systems Afar Erongo volcano-plutonic complex

Squeezed quantum hybrid system:Giant enhancement of magnon-phonon-spin interactions

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Science China(Physics,Mechanics & Astronomy) 2023年第11期66卷 233-234页

作者： franco Nori Theoretical Quantum Physics Laboratory Cluster for Pioneering ResearchRIKENWakoshiSaitama351-0198Japan Quantum Computing Center RIKENWakoshiSaitama351-0198Japan Physics Department The University of MichiganAnn ArborMichigan48109-1040USA

Quantum magnonics has recently attracted considerable interest not only in fundamental physics but also in applications,ranging from quantum information processing to quantum metrology[1].A unique merit of magnons,the quasiparticles or quantized unit of magnetic excitations in solids,is their ability to be effectively coupled with almost all different quantum information carriers,such as optical photons,mechanical phonons,superconducting qubits,and solid-state spins,which are otherwise difficult to be efficiently integrated together.

关键词： quantum magnon otherwise