New translational and experimental insights into the role of proresolving lipid mediators in inflammatory bowel disease

作     者：Lívia Bitencourt Pascoal Bruna Biazon Palma Fabio Henrique Mendonça Chaim Marina Moreira de Castro Tiago Andrade Damázio Ana Paula Menezes de Freitas Franceschini Marciane Milanski Lício AugustoVelloso Raquel Franco Leal 

作者机构：Inflammatory Bowel Disease Research LaboratoryColorectal Surgery UnitDepartment of SurgerySchool of Medical SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Metabolic DisordersSchool of Applied SciencesUniversity of CampinasCampinas 13083-878São PauloBrazil Laboratory of Cell SignalingSchool of Medical SciencesUniversity of CampinasCampinas 13083-864São PauloBrazil 

出 版 物：《World Journal of Experimental Medicine》 (世界实验医学杂志)

年 卷 期：2022年第12卷第1期

页      面：1-15页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the National Council for Scientific and Technological Development(CNPq)for Leal RF(301388/2018-0) the Post-doctoral Scholarship from Funding for Education,Research and Extension Support(FAEPEX),University of Campinas for Pascoal LB the Undergraduate Scholarship from the CNPq(125138/2020-2)for Palma BB the Undergraduate Scholarship from the São Paulo State Research Support Foundation(FAPESP)(2020/02571-9)for Damázio TA 

主　　题：Pro-resolving lipid mediators Anti-inflammatory cytokines Omega-3 Chronic inflammation Pro-inflammatory cytokines Inflammatory bowel disease 

摘      要：The resolution of inflammation is an active process,guided by specialized proresolution lipid mediators(SPMs).These mediators originate from polyunsaturated fatty acids,such as *** evidence suggests that the beneficial effects attributed to omega-3 are,at least in part,the result of the immunomodulatory action of the SPMs,which act systemically by overcoming inflammation and repairing tissue damage,without suppressing the immune *** studies suggest that an imbalance in the synthesis and/or activity of these compounds may be associated with the pathogenesis of several inflammatory conditions,such as inflammatory bowel disease(IBD).Thus,this review highlights the advances made in recent years with regard to the endogenous synthesis and the biological role of lipoxins,resolvins,protectins,and maresins,as well as their precursors,in the regulation of inflammation;and provides an update on the participation of these mediators in the development and evolution of IBD and the therapeutic approaches that these immunomodulating substances are involved in this context.