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A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon

World Journal of Gastroenterology 2007年第7期13卷 1079-1084页

作者： Aldo roda Patrizia Simoni Maria Magliulo Paolo Nanni Mario Baraldini Giulia roda Enrico roda Department of Pharmaceutical Sciences University of Bologna Via Belmeloro 6 Bologna 40126 Italy Department of Internal Medicine and Gastroenterology University of Bologna via Massarenti 9 Bologna 40126 Italy

AIM: To develop a new formulation with hydroxy propyl methyl cellulose and Shellac coating for extended and selective delivery of butyrate in the ileo-caecal region and colon. METHODS: One-gram sodium butyrate coated tablets containing 13C-butyrate were orally administered to 12 healthy subjects and 12 Crohn's disease patients and the rate of 13C-butyrate absorption was evaluated by 13CO2 breath test analysis for eight hours. Tauroursodeoxycholic acid (500 mg) was co-administered as a biomarker of oro-ileal transit time to determine also the site of release and absorption of butyrate by the time of its serum maximum concentration. RESULTS: The coated formulation delayed the 13C-butyrate release by 2-3 h with respect to the uncoated tablets. Sodium butyrate was delivered in the intestine of all subjects and a more variable transit time was found in Crohn's disease patients than in healthy subjects. The variability of the peak 13CO2 in the kinetic release of butyrate was explained by the inter-subject variability in transit time. However, the coating chosen ensured an efficient release of the active compound even in patients with a short transit time. CONCLUSION: Simultaneous evaluation of breath 13CO2 and tauroursodeoxycholic acid concentration- time curves has shown that the new oral formulation consistently releases sodium butyrate in the ileo-cecal region and colon both in healthy subjects and Crohn's disease patients with variable intestinal transit time. This formulation may be of therapeutic value in inflammatory bowel disease patients due to the appropriate release of the active compound.

关键词：公式化列方程式丁酸钠盲肠结肠

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A new iron free treatment with oral fish cartilage polysaccharide for iron deficiency chronic anemia in inflammatory bowel diseases:A pilot study

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World Journal of Gastroenterology 2007年第10期13卷 1575-1578页

作者： Andrea Belluzzi Giulia roda Francesca Tonon Antonio Soleti Alessandra Caponi Anna Tuci Aldo roda Enrico roda Enrico roda Gastroenterology UnitUniversity of BolognaS.Orsola HospitalVia Massarenti

AIM:To investigate the effect of a new oral preparation,highly concentrated in fish cartilage,in a group of inflammatory bowel diseases(IBD)patients with chronic iron deficient ***:In an open label pilot study,we supple-mented a group of 25 patients(11 with Crohn's disease and 14 with ulcerative colitis)in stable clinical conditions and chronic anemia with a food supplement which does not contain iron but contains a standardized fraction of fish cartilage glycosaminoglycans and a mixture of antioxidants(Captafer Medestea,Turin,Italy).Patients received 500 mg,twice a day during meals,for at least 4 *** were suggested to maintain their alimentary *** time 0 and after 2 and 4 mo,emocrome,sideremia and ferritin were *** data were analyzed with Student's t ***:Three patients relapsed during the study(2 in the 3rd mo,1 in the 4th mo),two patients were lost to follow up and two patients dropped out(1 for orticaria,1 for gastric burning).Of the remaining 18 patients,levels of serum iron started to rapidly increase within the 2nd mo of treatment,P < 0.05),whereas serum ferritin and hemoglobin needed a longer period to significantly improve their serum levels(mo 4)P < *** product was safe,easy to administer and well tolerated by ***:These data suggest a potential new treatment for IBD patients with iron deficiency chronic anemia and warrant further larger controlled studies.

关键词：炎症性肠病缺铁性慢性贫血鱼类软骨多糖口服无铁制剂治疗

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Inflammatory bowel disease: Moving toward a stem cell-based therapy

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World Journal of Gastroenterology 2008年第29期14卷 4616-4626页

作者： Giacomo Lanzoni Giulia roda Andrea Belluzzi Enrico roda Gian Paolo Bagnara Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy Gastroenterology Unit University of Bologna S.Orsola HospitalBologna 40126 Italy Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy "Giorgio Prodi" Interdepartmental Research Centre for Cancer Research University of Bologna Bologna 40138 Italy

The incidence and prevalence of Crohn's disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. The modern hygienic lifestyle is probably at the root of a disease where, in genetically susceptible hosts, the intestinal commensal flora triggers dysregulated immune and inflammatory responses. Current therapies ranging from anti-inflammatory drugs to immunosuppressive regimens, remain inadequate. Advances in our understanding of the cell populations involved in the pathogenetic processes and recent findings on the regenerative, trophic and immunoregulatory potential of stem cells open new paths in IBD therapy. Hematopoietic and mesenchymal stem cells are catalyzing the attention of IBD investigators. This review highlights the pivotal fi ndings for stem cell-based approaches to IBD therapy and collects the encouraging results coming in from clinical trials.

关键词：间叶干细胞造血干细胞肠炎治疗方法

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G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence

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World Journal of Gastroenterology 2009年第43期15卷 5449-5454页

作者： Francesca Lodato Francesco Azzaroli Maria Rosa Tamè Maria Di Girolamo Federica Buonfiglioli Natalia Mazzella Paolo Cecinato Enrico roda Giuseppe Mazzella Department of Digestive Diseases and Internal Medicine University of BolognaBologna 40138Italy

AIM:To evaluate the efficacy of granulocyte colony stimulating factors(G-CSF)in liver transplanted patients with hepatitis C(HCV)recurrence and Pegylated-IFN α-2b induced neutropenia,and to evaluate the impact of G-CSF administration on virological response. METHODS:Sixty-eight patients undergoing antiviral treatment for post-liver transplantation(OLT)HCV recurrence were *** patients developing neutropenia received G-CSF. RESULTS:Twenty three(34%)received *** neutrophil count at the onset of neutropenia was 700/mmc(range 400-750/mmc);after 1 mo of G-CSF it increased to 1210/mmc(range 300-5590/mmc) (P<0.0001).Three patients did not respond to G-CSF. Treatment duration was similar in neutropenic and non-neutropenic *** differences in the rate of discontinuation,infections or virological response were observed between the two groups.G-CSF was protective for the onset of de novo autoimmune hepatitis(P<0.003). CONCLUSION:G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasingneutrophil count,prolonging treatment and leading to sustained virological response(SVR)rates comparable to non-neutropenic *** prevents the occurrence of de novo autoimmune hepatitis.

关键词：丙型肝炎病毒中性粒细胞干扰素α 聚乙二醇 CSF 肝移植粒细胞集落刺激因子患者

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ABTL0812 enhances antitumor effect of paclitaxel and reverts chemoresistance in triple-negative breast cancer models

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Cancer Communications 2022年第6期42卷 567-571页

作者： Emma Polonio-Alcala Sònia Solé-Sánchez Pau Munoz-Guardiola Elisabet Megías-roda Héctor Perez-Montoyo Marc Yeste-Velasco Jose Alfón Jose Miguel Lizcano Carles Domènech Santiago Ruiz-Martínez Teresa Puig New Therapeutic Targets Laboratory(TargetsLab)-Oncology Unit Department of Medical SciencesUniversity of GironaGirona 17003Spain Product Process and Production Engineering Research Group(GREP)Department of Mechanical Engineering and Industrial ConstructionUniversity of GironaGirona 17003Spain Ability Pharmaceuticals SLCerdanyola del VallesBarcelona 08290Spain Protein Kinases and Signal Transduction Laboratory Department de Bioquimica i Biologia Molecular and Institut de NeurocienciesUniversitat Autonoma de BarcelonaBellaterraBarcelona 08193Spain

Dear Editor,Triple-negative breast cancer(TNBC)accounts for 20%of all breast carcinomas and lacks a validated targeted therapy;thus,currently,cytotoxic chemotherapy is the treatment of choice[1].Compared with other breast cancer types,patientswith TNBCare younger,have larger tumors,a higher risk of metastasis,and a higher rate of recurrence[2].Among all the subtypes described by Lehmann et al.[3],mesenchymal-like and mesenchymal stem-like(MSL)subtypes had the lowest 5-year distant metastasis-free survival rates.

关键词： ABTL0812 TRIB3 Autophagy Breast Cancer Targeted Therapy Chemoresistance

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Why is it difficult to accurately predict the COVID-19 epidemic?

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Infectious Disease Modelling 2020年第1期5卷 271-281页

作者： Weston C.roda Marie B.Varughese Donglin Han Michael Y.Li Department of Mathematical and Statistical Sciences University of AlbertaEdmontonAlbertaT6G 2G1 Canada Analytics and Performance Reporting Branch Alberta HealthEdmontonAlbertaT5J 2N3Canada

Since the COVID-19 outbreak in Wuhan City in December of 2019,numerous model predictions on the COVID-19 epidemics in Wuhan and other parts of China have been *** model predictions have shown a wide range of *** our study,we demonstrate that nonidentifiability in model calibrations using the confirmed-case data is the main reason for such wide *** the Akaike Information Criterion(AIC)for model selection,we show that an SIR model performs much better than an SEIR model in representing the information contained in the confirmed-case *** indicates that predictions using more complex models may not be more reliable compared to using a simpler *** present our model predictions for the COVID-19 epidemic in Wuhan after the lockdown and quarantine of the city on January 23,*** also report our results of modeling the impacts of the strict quarantine measures undertaken in the city after February 7 on the time course of the epidemic,and modeling the potential of a second outbreak after the return-to-work in the city.

关键词： COVID-19 epidemic in Wuhan SIR and SEIR models Bayesian inference Model selection Nonidentifiability Quarantine Peak time of epidemic

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Therapeutic effectiveness of echo-guided percutaneous radiofrequency ablation therapy with a LeVeen needle electrode in hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第7期12卷 1098-1104页

作者： Luigi Solmi Giovanni Nigro Enrico roda Gastroenterological Unit Polyclinic Hospital Sant'Orsola-MalpighiUniversity School of MedicineBolognaItaly

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间... 详细信息

瞄准：在在肝脏硬化症的病人获得肝细胞癌(HCC ) 的坏死调查射频脱离(RFA ) 的结果并且在与 HCC 的复发和对待的病人的幸存的关系估计 RFA 的结果。方法：有 63 HCC 的 56 个连续肝脏硬化症的病人与在 2000 年 5 月和 2004 年 5 月之间的 RFA 被对待。HCC 的直径从 1 厘米到 5 厘米(平均数 2.8 厘米) 。在所有情况中， RFA 用可扩充的针电极(LeVeen 针) 在超声指导下面与经皮的途径被执行。治疗功效和复发与双阶段的螺线被评估计算断层摄影术(CT ) 。结果：在单个或多重的治疗以后的完全的坏死在 96.8% 被完成(61/63 ) 肿瘤。我们在 32.3 个月的吝啬的后续期间在 23 个病人(41%) 在完全的坏死以后观察了复发。复发在 2 个病人(8.6%) 并且在在 21 的不同片断是本地的(91.4%) 。主要复杂并发症发生在 3 个病人(4%) 。在后续时期期间， 32 (57.1%) 病人们死了；15 由于 HCC 的前进， 11 从肝失败， 3 从食道的静脉曲张流血并且 3 从不与肝有关的原因疾病。结论：有 LeVeen 针的 RFA 是为在肝脏硬化症的病人的 HCC<5 厘米的有效、安全的治疗。这治疗多远影响病人的幸存率，还得被建立。建立治疗在不同片断阻止复发变得重要，例如干扰素治疗。

关键词：治疗效果射频消融肝细胞癌并发症

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Unique immunological profile in patients with COVID-19

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Cellular & Molecular Immunology 2021年第3期18卷 604-612页

作者： Stefania Varchetta Dalila Mele Barbara Olivier Stefania Mantovani Serena Ludovisi Antonella Cerino Raffaele Bruno Alberto Castelli Mario Mosconi Marco Vecchia Silvia roda Michele Sachs Catherine Klersy Mario U.Mondelli Division of Infectious Diseases Ⅱ and Immunology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Internal Medicine and Therapeutics University of PaviaPaviaItaly Division of Infectious Diseases I Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical SurgicalDiagnosticand Pediatric SciencesUniversity of PaviaPaviaItaly Division of Orthopaedics and Traumatology Fondazione IRCCS Polidinico San MatteoPaviaItaly Department of Clinical-Surgical Diagnostic and Pediatric SciencesUniversity of PaviaPaviaItaly Clinical Epidemiology&Biometry Unit IRCCS Fondazione Polidinico San MatteoPaviaItaly

The relationship between severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)and host immunity is poorly *** performed an extensive analysis of immune responses in 32 patients with severe COVID-19,some of whom succumbed A control population of healthy subjects was *** with COVID-19 had an altered distribution of peripheral blood lymphocytes,with an increased proportion of mature natural killer(NK)cells and low T-cell *** cells and CD8^(+)T cells overexpressed T-cellimmunoglobulin and mucin domain-3(TIM-3)and *** cell exhaustion was attested by increased frequencies of programmed cell death protein 1(PD-1)positive cells and reduced frequencies of natural killer group 2 member D(NKG2D)-,DNAX accessory molecule-1(DNAM-1)-and sialic acid-binding Ig-like lectin 7(Siglec-7)-expressing NK cells,associated with a reduced ability to secrete interferon(IFN)γ.Patients with poor outcome showed a contraction of immature CD56^(bright) and an expansion of mature CD57^(+)F_(CEI)Rlγ^(eng) adaptive NK cells compared to *** serum levels of IL-6 were also more frequently identified in deceased patients compared to *** note,monocytes secreted abundant quantities of IL-6,IL-8,and IL-1β which persisted at lower levels several weeks after recovery with concomitant normalization of CD69,PD-1 and TIM-3 expression and restoration of CD8^(+)T cell numbers.A hyperactivated/exhausted immune response dominate in severe SARS-CoV-2 infection,probably driven by an uncontrolled secretion of inflammatory cytokines by *** findings unveil a unique immunological profile in COVID-19 patients that will help to design effective stage-specific treatments for this potentially deadly disease.

关键词： C0VID-19 NK cells TIM-3 IL6 Monocytes

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膨胀剂和超吸水性聚合物（SAP）对砂浆力学性能和抗裂性的影响

膨胀剂和超吸水性聚合物（SAP）对砂浆力学性能和抗裂性的影响

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作者： roda Roble Elmi 天津大学

学位级别：硕士

水泥基材料的收缩导致材料开裂并最终缩短结构的寿命。解决此问题的一种方法是添加膨胀剂以减少收缩。另一种方法是添加超吸水性聚合物（SAP）,在这项研究中,对掺膨胀剂和SAP砂浆的力学性能和开裂性能进行了研究。本文的主要内容如下:（... 详细信息

水泥基材料的收缩导致材料开裂并最终缩短结构的寿命。解决此问题的一种方法是添加膨胀剂以减少收缩。另一种方法是添加超吸水性聚合物（SAP）,在这项研究中,对掺膨胀剂和SAP砂浆的力学性能和开裂性能进行了研究。本文的主要内容如下:（1）对单掺三种不同类型的膨胀剂（HEA,SY-G和UEA）在水泥砂浆中力学性能和开裂性能研究。（2）双掺膨胀剂和高吸水性聚合物（SAP）对力学性能和抗裂性的影响。具体的讲,在水泥砂浆中单独引入三种膨胀剂HEA、SY-G和UEA,按水泥重量分别为2%、4%、6%、8%、10%和12%掺入。另一种设计是在砂浆中同时含有2%、4%、6%、8%、10%和12%的膨胀剂HEA和SY-G,高吸水性聚合物（SAP）以水泥质量的0.5%掺入。相关试验有5个:（1）流动性测试;（2）抗压强度试验;（3）抗折强度试验;（4）圆环约束收缩试验;（5）外方内圆偏心约束收缩试验。其主要成果如下:（1）在单一掺量情况下,三种膨胀剂可以改善砂浆的流动性。从7d和28d砂浆的强度结果来看,除UEA外,其它两种膨胀剂的强度都有所提高,SY-G的表现优于HEA。砂浆中添加4%的SY-G膨胀剂的效果优于其它膨胀剂,其砂浆28d的抗折强度可达9.2MPa,抗压强度达到76.7MPa。（2）在开裂时间方面,与普通砂浆相比,SY-G型膨胀剂明显延迟了环形试样和外方内圆偏心试样的开裂时间,而HEA和UEA型膨胀剂砂浆的延缓开裂时间较短。（3）在将SY-G与SAP组合的情况下,结果表明抗压和弯曲强度都小于仅有SY-G的情况。对于将HEA与SAP相结合的情况也是如此。（4）至于开裂时间,与仅使用SY-G的情况相比,将SY-G与SAP组合的情况导致开裂时间短于只掺SY-G的砂浆。对于将HEA与SAP相结合的情况亦是如此。基于这些结果,以下优选顺序是膨胀剂对控制裂开裂性能的影响:SY-G＞HEA＞UEA。因此,不建议在混凝土中同时使用SAP和膨胀剂。

关键词：胶凝材料膨胀剂高吸水性聚合物(SAP) 抗裂性约束收缩

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Proton pump inhibitor treatment of patients with gastroesophageal reflux-related chronic cough:A comparison between two different daily doses of lansoprazole

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World Journal of Gastroenterology 2006年第1期12卷 82-88页

作者： Fabio Baldi Roberta Cappiello Carlotta Cavoli Stefania Ghersi Francesco Torresan Enrico roda Department of Gastroenterology Metabolic and Infectious DiseasesS.OrsolaMalpighi HospitalBolognaItaly

瞄准：为了比较 lansoprazole 的二不同一日量，给 12 个星期并且到估计角色胃肠(官方补给) 是的调查为选择病人的标准。方法：从 45 ，病人们为 unexplained 提交了长期的坚持的咳嗽， 36 有至少一官方补给的调查(内视镜检查法，食道的... 详细信息

瞄准：为了比较 lansoprazole 的二不同一日量，给 12 个星期并且到估计角色胃肠(官方补给) 是的调查为选择病人的标准。方法：从 45 ，病人们为 unexplained 提交了长期的坚持的咳嗽， 36 有至少一官方补给的调查(内视镜检查法，食道的 pH-metry 和质子的4星期的试用抽的 24-h 禁止者( PPI )治疗)积极并且随机被分配收到 30 mg lansoprazole o.d 或 30 mg 为 12 个星期的 lansoprazole b.i.d 。症状在 PPI 测试(访问 2 ) 以后并且在 12 星期的 lansoprazole 治疗经期(访问 3 ) 以后在基线(访问 1 ) 被评估。结果：35 个病人完成了学习协议。报导的 21 个病人(60.0%) 没有二个治疗组之间的差别从他们的咳嗽完成地势(58.8% 和 61.1% 没在 30 mg lansoprazole 和 60 个 mg lansoprazole 组有咳嗽，分别地) 。在治疗的结束从他们的咳嗽有完全的地势的超过 80% 病人显示出积极回答到 PPI 测试。结论：12 星期甚至在标准一日量的 lansoprazole 治疗，在有长期的坚持的咳嗽的病人是有效的。对起始的 PPI 测试的积极回答似乎是为选择对治疗作出回应的病人的最好的标准。

关键词：抑制剂胃疾病食管疾病慢性咳嗽羊毛二烯

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