Inflammatory bowel disease: Moving toward a stem cell-based therapy
Inflammatory bowel disease: Moving toward a stem cell-based therapy作者机构：Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy Gastroenterology Unit University of Bologna S.Orsola HospitalBologna 40126 Italy Department of Histology Embryology and Applied Biology University of BolognaBologna 40126 Italy "Giorgio Prodi" Interdepartmental Research Centre for Cancer Research University of Bologna Bologna 40138 Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2008年第14卷第29期
页 面：4616-4626页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Cassa di Risparmio in Bologna CARISBO Foundation University of Bologna, RFO 2006
主 题：Inflammatory bowel disease Stem cells Hematopoietic stem cell Mesenchymal stem cells Celltherapy
摘 要：The incidence and prevalence of Crohn s disease (CD) and ulcerative colitis (UC), the two major forms of inflammatory bowel diseases (IBD), are rising in western countries. The modern hygienic lifestyle is probably at the root of a disease where, in genetically susceptible hosts, the intestinal commensal flora triggers dysregulated immune and inflammatory responses. Current therapies ranging from anti-inflammatory drugs to immunosuppressive regimens, remain inadequate. Advances in our understanding of the cell populations involved in the pathogenetic processes and recent findings on the regenerative, trophic and immunoregulatory potential of stem cells open new paths in IBD therapy. Hematopoietic and mesenchymal stem cells are catalyzing the attention of IBD investigators. This review highlights the pivotal fi ndings for stem cell-based approaches to IBD therapy and collects the encouraging results coming in from clinical trials.
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