G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence
G-CSF in Peg-IFN induced neutropenia in liver transplanted patients with HCV recurrence作者机构：Department of Digestive Diseases and Internal Medicine University of BolognaBologna 40138Italy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2009年第15卷第43期
页 面：5449-5454页
核心收录：
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Granulocyte colony stimulating factors Liver transplantation Hepatitis C virus recurrence Antiviral treatment
摘 要：AIM:To evaluate the efficacy of granulocyte colony stimulating factors(G-CSF)in liver transplanted patients with hepatitis C(HCV)recurrence and Pegylated-IFN α-2b induced neutropenia,and to evaluate the impact of G-CSF administration on virological response. METHODS:Sixty-eight patients undergoing antiviral treatment for post-liver transplantation(OLT)HCV recurrence were *** patients developing neutropenia received G-CSF. RESULTS:Twenty three(34%)received *** neutrophil count at the onset of neutropenia was 700/mmc(range 400-750/mmc);after 1 mo of G-CSF it increased to 1210/mmc(range 300-5590/mmc) (P0.0001).Three patients did not respond to G-CSF. Treatment duration was similar in neutropenic and non-neutropenic *** differences in the rate of discontinuation,infections or virological response were observed between the two groups.G-CSF was protective for the onset of de novo autoimmune hepatitis(P0.003). CONCLUSION:G-CSF administration is effective in the case of Peg-IFN induced neutropenia increasingneutrophil count,prolonging treatment and leading to sustained virological response(SVR)rates comparable to non-neutropenic *** prevents the occurrence of de novo autoimmune hepatitis.
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