A new iron free treatment with oral fish cartilage polysaccharide for iron deficiency chronic anemia in inflammatory bowel diseases:A pilot study

作     者：Andrea Belluzzi Giulia Roda Francesca Tonon Antonio Soleti Alessandra Caponi Anna Tuci Aldo Roda Enrico Roda 

作者机构：Enrico RodaGastroenterology UnitUniversity of BolognaS.Orsola HospitalVia Massarenti 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第10期

页      面：1575-1578页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：炎症性肠病 缺铁性慢性贫血 鱼类软骨多糖 口服 无铁制剂 治疗 

摘      要：AIM:To investigate the effect of a new oral preparation,highly concentrated in fish cartilage,in a group of inflammatory bowel diseases(IBD)patients with chronic iron deficient ***:In an open label pilot study,we supple-mented a group of 25 patients(11 with Crohn s disease and 14 with ulcerative colitis)in stable clinical conditions and chronic anemia with a food supplement which does not contain iron but contains a standardized fraction of fish cartilage glycosaminoglycans and a mixture of antioxidants(Captafer Medestea,Turin,Italy).Patients received 500 mg,twice a day during meals,for at least 4 *** were suggested to maintain their alimentary *** time 0 and after 2 and 4 mo,emocrome,sideremia and ferritin were *** data were analyzed with Student s t ***:Three patients relapsed during the study(2 in the 3rd mo,1 in the 4th mo),two patients were lost to follow up and two patients dropped out(1 for orticaria,1 for gastric burning).Of the remaining 18 patients,levels of serum iron started to rapidly increase within the 2nd mo of treatment,P 0.05),whereas serum ferritin and hemoglobin needed a longer period to significantly improve their serum levels(mo 4)P *** product was safe,easy to administer and well tolerated by ***:These data suggest a potential new treatment for IBD patients with iron deficiency chronic anemia and warrant further larger controlled studies.