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Lessons fr.m glaucoma: r.thinking the fluid-br.in bar.ier. in common neur.degener.tive disor.er.

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Neur.l r.gener.tion r.sear.h 2019年第6期14卷 962-966页

作者： Fr.ncisco Javier.carreras Depar.ment of Sur.er. Faculty of MedicineUniversity of Granada

Glaucoma has been r.cently char.cter.zed as a member.of the gr.up of anoikis-r.lated diseases. Anoikis, a for. of apoptosis, can be tr.gger.d by the unfastening of adher.nt junctions pr.sent in astr.cytes. In those ar.as of the centr.l ner.ous system in which the soma of the neur.ns or.their.axons and dendr.tes ar. metabolically dependent on the activity of astr.cytes, a der.ngement of the lactate shuttle caused by a separ.tion between the plasma membr.nes of neur.ns and astr.cytes would r.sult in metabolic impair.ent of the neur.ns themselves. In glaucoma, the tr.gger.ng event has been attr.buted to the poster.or.deviation of aqueous humor.towar.s the astr.cyte-r.ch pr.laminar.tissue of the optic ner.e head. The mean calcium content in the aqueous is able to inter.er. with calcium-dependent adher.nt junctions and induce anoikis of the astr.cytes. As the cer.br.spinal fluid has a similar.base calcium concentr.tion, a shunt of cer.br.spinal fluid thr.ugh the cer.br.l par.nchyma would be able to inter.er. in the astr.cytic ar.hitectur. with dir. consequences to the metabolically dependent neur.ns. Her. the similitude between glaucoma,amyotr.phic later.l scler.sis and Alzheimer.s disease ar. discussed and the concept of the br.ak in the fluid-br.in bar.ier. as an event separ.ted fr.m the blood-br.in bar.ier. is str.ssed.

关键词： fluid-br.in bar.ier. blood-br.in bar.ier cer.br.spinal fluid aqueous humor calcium ion glaucoma amyotr.phic later.l scler.sis Alzheimer.s disease

Pathogenesis of glaucoma: how to pr.vent ganglion cell fr.m axonal destr.ction?

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Neur.l r.gener.tion r.sear.h 2014年第23期9卷 2046-2047页

作者： Fr.ncisco Javier.carreras Depar.ment of Sur.er.(Ophthalmology) Faculty of MedicineUniversity of Granada

Glaucoma is the main cause of ir.ever.ible blindness globally, but the pathogenesis of glaucoma is still pending consensus. In spite of gr.at advances dur.ng the 20th and ear.y 21st centur.es in ter.s of detailed knowledge of pathological pr.cesses that take place in glaucoma, the exact pathogenesis is much less clear. Hypotheses abound, and the most r.sear.hed ar.as ar. ischemia at the optic ner.e head, blockade of ganglion cell axonal tr.nspor., per.papillar. atr.phy, and changes in the char.cter.stics of the lamina cr.br.sa （Nucci et al., 2008）.

关键词： Pathogenesis of glaucoma r.Cs cell

Glaucoma and amyotr.phic later.l scler.sis,two kindr.d diseases?

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Neur.l r.gener.tion r.sear.h 2016年第9期11卷 1415-1417页

作者： Fr.ncisco Javier.carreras Sur.er. Depar.ment Faculty of MedicineUniversity of Granada

Amyotr.phic later.l scler.sis （ALS）, a pr.dominantly spor.dic disease with unknown etiology and pathogeny, is a member.of a gr.up known as motor.neur.n diseases （MND）. The heter.geneity of the clinical pr.sentation of the disease is a fundamental aspect of ALS and is de- ter.ined by the var.able engagement of its upper.motor.neur.n （UMN） and lower.motor.neur.n （LMN） components （r.vits and La Spada, 2009）.

关键词： r.Cs Glaucoma and amyotr.phic later.l scler.sis,two kindr.d diseases Figur.

The inver.ed r.tina and the evolution of ver.ebr.tes:an evo-devo per.pective

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Annals of Eye Science 2018年第1期3卷 121-131页

作者： Fr.ncisco Javier.carreras Depar.ment of Sur.er.(Ophthalmology) Medical SchoolUniversity of GranadaGranadaSpain

The inver.ed r.tina is a basic char.cter.stic of the ver.ebr.te *** implies that ver.ebr.tes must have a common ancestor.with an inver.ed *** the two gr.ups of chor.ates,cephalochor.ates have an inver.ed r.tina and ur.chor.ates a dir.ct ***,r.cent genetics studies favor.ur.chor.ates as the closest ancestor.to *** evolution of incr.asingly complex or.ans such as the eye implies not only tissular.but also str.ctur.l modifications at the or.an *** these configur.tional modifications give r.se to a functional eye at any step is still subject to debate and *** we pr.pose an or.er.y sequence of phylogenetic events that closely follows the sequence of developmental eye for.ation in extant *** pr.gr.ssive str.ctur.l complexity has been clear.y r.cor.ed dur.ng ver.ebr.te development at the per.od of *** the chain of incr.asing eye complexity in Mollusca that leads to the bicamer.l eye of the octopus and the developmental sequence in ver.ebr.tes,we delineate the par.llel evolution of the two-chamber.d eye of ver.ebr.tes star.ing with an ear.y ectoder.al *** sequence allows for.some inter.sting pr.dictions r.gar.ing the eyes of not pr.ser.ed inter.ediar. *** clue to under.tanding the inver.ed r.tina of ver.ebr.tes and the similar.ty between the sequence followed by Mollusca and chor.ates is the notion that the eye in both cases is an ectoder.al str.ctur.,in contr.st to an exclusively(de novo)neur.ectoder.al or.gin in the eye of *** analysis places cephalochor.ates as the closest br.nch to ver.ebr.tes contr.r. to ur.chor.ates,claimed as a closer.br.nch by some r.sear.her. that base their.pr.posals in a genetic analysis.

关键词： Camer.l eye ectoder.al/neur.ectoder.al or.gin dir.ct and inver.ed r.tina ver.ebr.te/inver.ebr.te eye evo-devo

r.fr.ctive outcomes after.V4c Tor.c collamer.lens implantation over.1y of follow-up

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Inter.ational Jour.al of Ophthalmology(English edition) 2024年第7期17卷 1322-1330页

作者： Humber.o carreras-Díaz Josefina r.ñones de Abajo Mar.a del r.sar.o carreras-Díaz Amalia Lor.nte-Velázquez Vithas Eur.canar.as Las Palmas de Gran Canaria 35004Spain Univer.ity Hospital of Gir.na Doctor.Josep Tr.eta Gerona 17007Spain Depar.ament of Optometr. and Vision Faculty of Optics and OptometryComplutense University of MadridMadrid 28040Spain

AIM:To evaluate r.fr.ctive outcomes and cor.eal astigmatism changes after.Tor.c implantable collamer.lens with a centr.l por.(V4c T-ICL)implantation over.1y of ***:A r.tr.spective study was per.or.ed including 50 eyes of 50 patients that under.ent V4c T-ICL ***(UDVA)and cor.ected(CDVA)distance visual acuities,r.fr.ction,r.fr.ctive and cor.eal astigmatism changes and cor.eal coupling cor.ection wer. evaluated pr.oper.tively,1 and 12mo *** analysis was used for.astigmatism *** of adjustment(CAdj)was calculated for.cor.eal coupling ***:The mean UDVA achieved was 0.03 logMAr.at 1mo and r.mained unchanged thr.ughout the whole follow-up(P=0.193).At the last visit,84%of the eyes achieved a CDVA of 0.00 logMAr.or.*** spher.cal equivalent r.fr.ction(SEQ),96%of eyes wer. r.nges of±1.00 D and 84%of them within±0.50 ***,94%of eyes had a r.maining r.fr.ctive cylinder.within±1.00 D and 78%of them within±0.50 ***,SEQ and r.fr.ctive cylinder.r.main stable over.the postoper.tive follow-up(P=1.000 and P=0.660,r.spectively).In ter.s of sur.ically induced astigmatism(SIA),no statistically significant differ.nces wer. found over.the follow-up(P=0.102)and under.cor.ection was found with a cor.ection index lower.than the unit at each visit.A ker.tometr.c astigmatism induced of 0.59±0.53(vector.mean:0.26×73º)D was r.ached at the last *** significant changes in ter.s of cor.eal astigmatism or.entation wer. r.por.ed over.post-sur.er. visits(P=0.129 and P=0.097 at 1 and 12mo r.spectively).No clinical significance was found for.CAdj on with-the-r.le *** postoper.tive complications r.sulting fr.m the sur.er. wer. ***:r.fr.ctive outcomes suggest that the V4c T-ICL implantation for.cor.ection of myopic astigmatism was satisfactor. in ter.s of effectiveness,safety,and stability dur.ng 1y of *** astigmatism induced by the incision ar.und 0.5 D is achieved

关键词： V4c Tor.c collamer.lens cor.eal astigmatism sur.ically induced astigmatism cor.eal coupling

Degener.tive myopia: mechanical theor.es r.visited

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Annals of Eye Science 2018年第1期3卷 132-135页

作者： F.Javier.carreras Depar.ment of Sur.er.(Ophthalmology) Medical SchoolUniversity of GranadaGranadaSpain

The ar.icle discusses the ear.y abandonment of mechanical theor.es about eye enlar.ement in degener.tive myopia at the tur. of the 20th *** that time,the number.of theor.es about myopia gr.w unr.str.cted,but with scant suppor. fr.m the exper.mental *** mechanical theor.es vanished as a new wave of metabolism-based theor.es appear.d,pr.pelled by the huge advances in molecular.*** techniques allow r.consider.ng those theor.es and to put them to test with higher.confidence.

关键词： Degener.tive myopia mechanical theor.es extr. and intr.ocular.muscles botulinum toxin(BT)

Diagnostic value of sper. DNA fr.gmentation and sper. high-magnification for.pr.dicting outcome of assisted r.pr.duction tr.atment

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Asian Jour.al of Andr.logy 2013年第6期15卷 790-794,I0008-I0009页

作者： Gemma López r.fael Lafuente Miguel A Checa r.món carreras Mar.o Br.ssesco Centr. de Infer.ilidad y r.pr.duccion Humana (Clr.) E-08017 Barcelona Spain Depar.ment of Obstetr.cs and Gynecology Hospital Universitari del Mar Universitat AutOnoma de Barcelona E-08003 Barcelona Spain

Over.the last year., major.impr.vements in the field of male infer.ility diagnosis have been achieved. The aim of this study was to deter.ine the diagnostic usefulness of sper. DNA integr.ty and sper. vacuolisation for.pr.dicting outcome in infer.ile couples under.oing in vitr.fer.i lisation （IVF） and intr.cytoplasmic sper. injection （ICSI） tr.atments. A cohor. study fr.m 152 infer.ile couples under.oing sper. DNA fr.gmentation and high-magnification tests pr.or.to an assisted r.pr.duction tr.atment was designed. We found that the most pr.dictive cutoff for.pr.gnancy was 25.5% of DNA fr.gmentation with a negative pr.dictive value of 72.7% （P=0.02）. For.the degr.e of vacuolisation, the best pr.dictor.of pr.gnancy was 73.5% of vacuolated sper. gr.des Ⅲ ＋ Ⅳ with a negative pr.dictive value of 39.4% （P=0.09）, which was not statistically significant. In conclusion, sper. DNA fr.gmentation gr.ater.than 25.5% could be associated with higher.pr.bability of failur. IVF tr.atment. r.gar.ing the r.sults of the sper. analysis at high magnification, they do not allow us to pr.dict whether.or.not oatients will become pr.gnant.

关键词： DNA fr.gmentation high-magnification IVF vacuoles

Micr.engineer.ng double layer.hydr.gel str.ctur.s towar.s the r.capitulation of the hematopoietic stem cell niche

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Science Bulletin 2018年第20期63卷 1319-1323页

作者： Pilar.carreras r.dr.go Cor.r.m Chaves Miguel Gallar.o Alejandr. Or.iz Joaquin Mar.inez Lopez Samuel K.Sia Depar.ment of Biomedical Engineer.ng Columbia UniversityNew YorkNY 10032USA Hematology Depar.ment Research Institute i+12Hospital 12 OctubreMadrid 2804Spain Hematological Malignancies Clinical r.sear.h Unit H120 CNIOMadrid 28029Spain

Adult stem cells,especially fr.m bone mar.ow,have a tr.mendous ther.peutic potential,and its application in r.gener.tive medicine has been incr.asingly studied [1,2].It is well known that thr.e-dimensional (3D)cell cultur. matr.x pr.motes many biological r.levant functions not obser.ed in two-dimensional (2D) monolayer.cell cultur. [3]and ther.for.,engineer.ng 3D cell cultur. platfor.s to mimic the native in vivo biological systems r.pr.sents a r.alistic appr.ach for.studies of bone mar.ow stem cells. High-thr.ughput micr.fluidics constitutes a pr.mising technology to gener.te hydr.gel thr.e dimensional constr.cts [4,5],however. its application to host adult stem cells r.mains still a challenge.

关键词： hydr.gel hematopoietic stem cell

Temper.tur.-dependent phonon spectr. of magnetic r.ndom solid solutions

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npj Computational Mater.als 2018年第1期4卷 606-612页

作者： Yuji Ikeda Fr.tz Kör.ann Biswanath Dutta Abel carreras Atsuto Seko Jör. Neugebauer.Isao Tanaka Depar.ment of Mater.als Science and Engineer.ng Kyoto UniversityKyoto 606-8501Japan Center.for.Elements Str.tegy Initiative for.Str.ctur.l Mater.als(ESISM) Kyoto UniversityKyoto 606-8501Japan Max-Planck-Institut für.Eisenfor.chung GmbH D-40237 DüsseldorfGermany Depar.ment of Mater.als Science and Engineer.ng Delft University of TechnologyMekelweg 22628 CD DelftNetherlands Pr.cur.or. r.sear.h for.Embr.onic Science and Technology(Pr.STO) Japan Science and Technology Agency(JST)Kawaguchi 332-0012Japan Center.for.Mater.als r.sear.h by Infor.ation Integr.tion National Institute for Materials Science(NIMS)Tsukuba 305-0047Japan Nanostr.ctur.s r.sear.h Labor.tor. Japan Fine Ceramics CenterNagoya 456-8587Japan

A fir.t-pr.nciples-based computational tool for.simulating phonons of magnetic r.ndom solid solutions including ther.al magnetic fluctuations is *** method takes fluctuations of for.e constants due to magnetic excitations as well as due to chemical disor.er.into *** developed appr.ach cor.ectly pr.dicts the exper.mentally obser.ed unusual phonon har.ening of a tr.nsver.e acoustic mode in Fe–Pd an Fe–Pt Invar.alloys with incr.asing *** peculiar.behavior.which cannot be explained within a conventional har.onic pictur.,tur.s out to be a consequence of ther.al magnetic *** pr.posed methodology can be str.ightfor.ar.ly applied to a wide r.nge of mater.als to r.veal new insights into physical behavior. and to design mater.als thr.ugh computation,which wer. not accessible so far.

关键词： magnetic r.ndom phonon