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秋葵多糖提取工艺优化及对力竭小鼠抗疲劳作用

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食品科技 2024年第1期49卷 177-182页

作者：孙晃渠彦超苏州工业园区服务外包职业学院江苏苏州223300 南京体育学院江苏南京210000

文章旨在探究秋葵多糖对小鼠力竭跑步疲劳的缓解作用。采用响应面法优化秋葵多糖提取工艺,通过力竭跑步试验评价其对小鼠抗疲劳能力相关指标的影响。结果表明:优化秋葵多糖的提取工艺条件为提取时间1 h、提取温度49℃、料液比1:18(g/m ... 详细信息

文章旨在探究秋葵多糖对小鼠力竭跑步疲劳的缓解作用。采用响应面法优化秋葵多糖提取工艺,通过力竭跑步试验评价其对小鼠抗疲劳能力相关指标的影响。结果表明:优化秋葵多糖的提取工艺条件为提取时间1 h、提取温度49℃、料液比1:18(g/m L),在此条件下秋葵多糖提取率为(28.95±2.65)%;秋葵多糖各剂量组的平均力竭跑步时间与空白对照组相比显著增加(P<0.05),同时对小鼠运动后肌糖原和肝糖原含量、乳酸脱氢酶、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶活性有显著升高作用(P<0.05),对肌酸激酶活性、丙二醛含量有显著降低作用(P<0.05),高剂量组与牛磺酸对照组对力竭跑步小鼠抗疲劳作用相当。研究表明秋葵多糖具有较好的抗疲劳作用。

关键词：秋葵多糖响应面提取工艺抗疲劳小鼠

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“出奇”与归真——王子武的艺术探索道路

美术 2024年第2期 48-51,F0003页

作者：刘艳卿屈健西北大学西安美术学院

在20世纪中国美术史上,王子武将西方写实观念与传统中国画笔墨语言融会贯通,形成了一种厚重而不失灵动、严谨而充满生机、朴茂而意蕴深远的艺术风格。关中黄土大地厚重的文化根脉、“徐蒋体系”的造型观念和传统文人绘画的笔墨语言直接... 详细信息

在20世纪中国美术史上,王子武将西方写实观念与传统中国画笔墨语言融会贯通,形成了一种厚重而不失灵动、严谨而充满生机、朴茂而意蕴深远的艺术风格。关中黄土大地厚重的文化根脉、“徐蒋体系”的造型观念和传统文人绘画的笔墨语言直接影响了王子武的艺术探索和理想追求,使其艺术道路呈现出一种入手于写实、出奇于写意、回归于写心的发展轨迹。

关键词：王子武人物画徐蒋体系长安画派

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对辊式油茶果籽壳清选机的设计与试验

农机化研究 2025年第2期47卷 105-113,164页

作者：王东寇欣廖伟康地曲振兴汤晶宇国家林业和草原局哈尔滨林业机械研究所哈尔滨150086 湖南丰沃机械制造有限公司湖南岳阳414000 湖南省林业科学院长沙410004

针对现有油茶果籽壳清选机清选效果不佳、茶籽损伤率高问题,设计了一种采用齿光辊清选原理的对辊式油茶果籽壳清选机。同时,对油茶籽、壳的物理特性进行了研究,对清选装置辊组排布方式、齿光辊组数、清选关键部件齿辊齿形和直径分别进... 详细信息

针对现有油茶果籽壳清选机清选效果不佳、茶籽损伤率高问题,设计了一种采用齿光辊清选原理的对辊式油茶果籽壳清选机。同时,对油茶籽、壳的物理特性进行了研究,对清选装置辊组排布方式、齿光辊组数、清选关键部件齿辊齿形和直径分别进行了设计,分析了清选状态时油茶壳受力情况。为验证对辊式油茶果籽壳清选机是否达到了预期设计目标,设计了三因素三水平正交试验,选取清选间隙、辊轴转速、喂入量为试验因素,以茶籽破碎率和清选率为评价指标,对清选机进行现场试验。结果表明:清选间隙为3.13 mm、轴辊转速为298.25 r/min、喂入量为1.51 t/h时,对辊式油茶果籽壳清选机获得最佳清选效果,此时茶籽破损率为3.30%,清选率为96.79%。

关键词：油茶果籽壳混合物清选机齿光辊清选

Preparation and Properties of Eco-Friendly Aerated Concrete Utilizing High-Volume Fly Ash with MgO and CaO Activators

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Journal of Renewable Materials 2022年第12期10卷 3335-3350页

作者： Xiaoling qu Xingshuo Yang Siqi li Changan Tian Zaibo Li Zhiguang Zhao School of Chemistry and Civil Engineering Shaoguan University Shaoguan512005China

The associated MgO in limestone is believed to affect the volume stability of cementitious materials at room tem-perature,which limits the utilization of low grade *** this study,MgO was used as an alkali activator instead of partial CaO to prepare the aerated concrete under hydrother mal *** expansion process was studied to evaluate the influence of the raw materials on the gas forming stability of the *** pore structure(porosity,pore size and its distribution)was analyzed by the image *** physic mechanical properties(density,strength,thermal properties)of concrete with the addition of MgO were comprehensively ***,the mineral compositions and morphology of the hydration products were analyzed to demonstrate the infuence mechanism of MgO on the mechanical *** results show that the final expansion rate of the slurry decreases with MgO content.A reasonable MgO content,ie,MgO/(MgO+CaO)<20%,con-tributes to improve the compressive strength,attributing to an increased reaction rate to C-S-H gel and *** addition of MgO causes the thermal conductivity and specific heat to *** pore structure is mainly related to the amount of air entraining *** study has a significance for the further utilization of magnesium-rich carbonates in the autoclaved building products.

关键词： Fly ash aerated concrete,strength thermal properties pore structure

靶向Robo1嵌合抗原受体修饰的NK92细胞对神经胶质瘤及神经母细胞瘤细胞的杀伤效果

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中华医学杂志 2018年第11期98卷 860-866页

作者：曲玥毕建忠山东大学第二医院神经内科济南250033

目的研究Roundabout1（Robo1）-CAR-NK92细胞在体外对神经胶质瘤细胞U87-MG及神经母细胞瘤细胞SH-sy5Y的体外杀伤以及探讨白细胞介素-15（IL-15）、IL-21和地塞米松对Robo1-CAR-NK92细胞增殖、活性和杀伤的影响以优化培养方案。方法用... 详细信息

目的研究Roundabout1（Robo1）-CAR-NK92细胞在体外对神经胶质瘤细胞U87-MG及神经母细胞瘤细胞SH-sy5Y的体外杀伤以及探讨白细胞介素-15（IL-15）、IL-21和地塞米松对Robo1-CAR-NK92细胞增殖、活性和杀伤的影响以优化培养方案。方法用慢病毒转染的方法构建Robo1-CAR-NK92细胞后分选扩增，并用流式细胞术检测阳性率。用流式细胞术的方法检测U87-MG及SH-sy5Y细胞表面Robo1的表达。用CCK-8试剂盒和动态活细胞成像的方法检测Robo1-CAR-NK92及NK92细胞对靶细胞的体外杀伤。用流式多重微珠阵列法检测杀伤过程中分泌的细胞因子含量。用锥虫蓝染色的方法检测经25 ng/ml的IL-15，25 ng/ml的IL-21和（或）50 nmol/L的地塞米松处理3 d后的Robo1-CAR-NK92及NK92细胞的计数及活性率。结果构建Robo1-CAR-NK92细胞并经分选扩增后检测阳性率为98.89%。流式细胞术检测结果显示，Robo1在U87-MG及SH-sy5Y细胞上表达的阳性率分别为88.14%，99.75%。Robo1-CAR-NK92细胞对靶细胞的杀伤率明显高于NK92的杀伤率（P〈0.05）。Robo1-CAR-NK92细胞在杀伤U87-MG细胞过程中分泌的IL-6、IL-10、TNF-α和IFN- γ较NK92细胞明显增多（P〈0.05）。IL-15能促进Robo1-CAR-NK92的增殖和活性而IL-21则起相反作用。IL-21、IL-15＋IL-21能增强NK92和Robo1-CAR-NK92细胞的杀伤效果。IL联用地塞米松能增强NK92和Robo1-CAR-NK92细胞的增殖和活性，但抑制二者的杀伤效果（除IL-15和地塞米松联用不影响Robo1-CAR-NK92细胞的杀伤效果外）。结论与NK92细胞比，Robo1-CAR-NK92细胞对神经胶质瘤及神经母细胞瘤细胞有更强大的杀伤效果。在本试验时间内，IL-15联用地塞米松处理Robo1-CAR-NK92细胞是最有利于Robo1-CAR-NK92细胞体外增殖的培养方案。

关键词：神经胶质瘤神经母细胞瘤 Roundabout蛋白免疫疗法过继

Al-Fe-Ce合金熔体结构及主要强化相形成的EET分析

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稀有金属 2020年第9期44卷 1003-1008页

作者：屈华刘伟东蒋新宇娄琦屈赫辽宁工业大学材料科学与工程学院辽宁锦州121001

在较慢冷却条件下,Al-Fe合金熔体中面心立方结构的近程有序原子集团占主导地位。基于EET(empirical electron theory of solids and molecules)理论,计算了Al-Fe-Ce合金熔体中fcc结构近程有序原子集团Al-Fe,Al-Ce,Al-Fe-Ce,α-Al和主要析出相Al3Fe,Al6Fe,Al8Fe4Ce和Al4Ce的价电子结构,分析了Ce对Al-Fe合金熔体和主要强化相形成的影响。研究发现:Al-Fe最强键的n1α-Al--Fe(n1为共价电子对数)比α-Al的n1α-Al大14.2%,Al-Fe近程有序原子集团为二元AlFe相的形成提供了形核条件。Al-Ce,Al-Fe-Ce最强键的n1α-Al-Ce,n1α-Al-Fe-Ce分别比AlFe的n1α-Al-Fe大38.2%,39.3%,Ce添加促进了Al-Ce,Al-Fe-Ce原子集团的形成,减少了Al-Fe原子集团,为AlCe,AlFeCe相的形成提供了形核条件。对于Al-Fe合金,由于FAl6Fe(F为结构单元总成键能力)小于FAl3Fe,所以Al6Fe相优先形成。对于Al-Fe-Ce合金,由于FAl8Fe4Ce

关键词： Al-Fe合金 Ce添加熔体结构强化相价电子结构

落叶松尺蛾核型多角体病毒形态特征及分子检测技术建立

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陆地生态系统与保护学报 2024年第1期4卷 59-65页

作者：王少博谢丹洁张泽辉刘云朋孔德治王青华曲良建中国林业科学研究院森林生态环境与自然保护研究所国家林业和草原局森林保护学重点实验室北京100091 北京蓝狐天敌技术有限公司北京100089 河北省塞罕坝机械林场北曼甸分场河北围场068450

【目的】落叶松尺蛾核型多角体病毒(Erannis ankeraria nucleopolyhedrovirus,EranNPV)是有效调控落叶松尺蛾种群数量和质量的重要生物因子,明确EranNPV超微形态学结构,研究并建立其精准灵敏的分子(PCR)快速检测技术,有助于深入探究该... 详细信息

【目的】落叶松尺蛾核型多角体病毒(Erannis ankeraria nucleopolyhedrovirus,EranNPV)是有效调控落叶松尺蛾种群数量和质量的重要生物因子,明确EranNPV超微形态学结构,研究并建立其精准灵敏的分子(PCR)快速检测技术,有助于深入探究该病毒的传播机制和林间流行规律,从而为利用该病毒持续控制落叶松尺蛾提供技术支撑。【方法】利用扫描电镜和透射电镜对EranNPV多角体的外部形态和内部结构特征进行观察;根据EranNPV的ac54基因设计用于PCR检测的特异性引物EaV,通过多种昆虫病毒的PCR扩增结果验证引物特异性,测试该PCR检测技术体系对EranNPV基因组DNA和病毒悬浮液的灵敏性。【结果】电镜观察结果表明,该病毒多角体多为表面光滑的不规则多面体,少数多角体表面散布孔洞凹陷,平均直径为1.43±0.20μm,多角体内的病毒粒子呈单束分布,平均长度为219.14±17.50 nm;以EaV为引物,只有EranNPV能够扩增到目的条带,利用EaV为引物建立的PCR检测技术对EranNPV基因组DNA的检测灵敏度可达10 fg/mL,对EranNPV悬浮液的检测灵敏度可达1×102 OBs/mL。【结论】EranNPV为典型的单粒包埋型核型多角体病毒,利用EaV引物建立的PCR检测技术具有高度的特异性和灵敏度,有望进一步应用于EranNPV的林间传播和流行病学研究当中。

关键词：落叶松尺蛾核型多角体病毒扫描电镜透射电镜 PCR检测

Acute Oral Toxicity Studies of a Chinese Herbal Preparation Shenrong Bunao Capsule

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Agricultural Biotechnology 2017年第3期6卷 62-63页

作者： Ping LI Xiangling qu Sibu MA Ming LIU The Second Affiliated Hospital of Guiyang College of Traditional Chinese Medicine Guiyang College of Traditional Chinese Medicine

[ Objectives] This study was conducted to evaluate the acute oral toxicity of Shenrong Bunao Capsule, and to provide a theoretical basis for drug devel- opmcn! and clinical trims. [ Methods] Kunming mice were randomly assigned into two groups： an experimental group and a control group. In experimental group, Shenrong Bunao Capsule solution at maximum concentration of 45% was administered orally by gavage once at a dose of 30 ml/kg body weight （ BW）, while an equal volume of saline solution was given in the control group. Then, the appearance, behavior, mental state, diet, feces, urine, coat, skin color, respiration, nose, eyes and oral secretions and other daily activities of the mice were observed for 14 d after drug administration. At the end of the experiment, the mice were dissected, and their main organs were examined histopathologically. [Results] The appearance, behavior, respiration, body posture, response to stimuli and weight gain of the mice in control group were all normal. All the mice given 13. 500 g/kg BW Shenrong Bunao Capsule were alive 14 d after drug administration, and their appearance, behavior, respiration, body posture, response to stimuli and weight gains did not show any abnormality. In addition, the body weights of male and female mice had no obvious difference between the experimental group and the control group at the binging, 7 and 14 d after drug administration （P 〈0.05）. [ Conclusions] A maximum dose 13. 500 g/kg BW Shenrong Bunao Capsule, which was equivalent to 141 times of the recommended dosage for adult men was given to the mice, and did not result in any apparent toxic effects, suggesting that the Chines herbal preparation Shenrong Bunao Capsule has very little acute toxicity, and the commonly recommended dosage in clinical trials is safe.

关键词： Shenrong Bunao Capsule Acute toxicity test Median lethal dose Maximum dose

Visit-to-visit glycated hemoglobin A1c variability in adults with type 2 diabetes: a systematic review and meta-analysis

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Chinese Medical Journal 2022年第19期135卷 2294-2300页

作者： Furong qu Qingyang Shi Yang Wang Yanjao Shen Kaixin Zhou Ewan R.Pearson Sheyu Li Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan 610041China Department of Guideline and Rapid Recommendation Chinese Evidence-Based Medicine CenterCochrane China Center and MAGIC China CenterWest China HospitalSichuan UniversityChengduSichuan 610041China School of Life Science University of Chinese Academy of ScienceBejing 100101China Divson of Population Health and Genomics Ninewells Hospital and School of MedicineUniversity of DundeeDundee DD19SYScotlandUnited Kingdom.

Background:Current practice uses the latest measure of glycated hemoglobin(HbAlc)to facilitate clinical *** have demonstrated that HbAlc variability links the risk of death and complications of ***,the role of HbAlc variability is unclear in clinical *** systematic review summarized the evidence of visit-to-visit HbAlc variability regarding different metrics in micro-and macro-vascular complications and death in people with type 2 ***:We searched PubMed,EMBASE(via OVID),and Cochrane Central Register(CENTRAL,via OVID)for studies investigating the association between HbAlc variability and adverse outcomes in patients with type 2 diabetes and performed random-effects meta-analysis stratified by HbAlc variability metrics in terms of standard deviation(SD),coefficient of variation(CV),and HbAlc variability score(HVS).Results:In people with type 2 diabetes,the highest quantile of all three HbAlc variability metrics(HbAlc-standard deviation[HbAlc-SD],HbAlc-coefficient of variance[HbAlc-CV],and HVS)is associated with increased risks of all-cause mortality,cardiovascular events,progression to chronic kidney disease,amputation,and peripheral *** example,the hazard ratio of HbAlc-SD on all-cause mortality was 1.89 with 95%confidence interval(95%CI)1.46–2.45(HbAlc-CV 1.47,95%CI 1.26-1.72;HVS 1.67,95%CI 1.34–2.09).Conclusions:High HbAlc variability leads to micro-and macro-vascular complications of type 2 diabetes and related *** with type 2 diabetes and high HbAlc variability need additional attention and care for the potential adverse outcomes.

关键词： Visit-to-visit HbAlc variability Type 2 diabetes Macrovascular complications All-cause mortality Glycated hemoglobin