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基于GIS技术分析长沙市2006-2013年手足口病流行病学特征分析

2013年中国药学大会暨第十三届中国药师周

作者： He Xu Xu-Dong yuan Bao-De Shen Jin Han qing-yuan lv Ling Dai Ming-Gui Lin Chao Yu Jin-Xia Bai Hai-Long yuan Department of Pharmacy 302 Military Hospital of China School of Pharmacy Chengdu University of Traditional Chinese Medicine School of Science Monmouth University Institute of Tuberculosis 309 Military Hospital of China

In the present studies, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabrics （HGFs） was prepared by graft copolymerization of N-isopropylacrylamide （NIAAm） and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the HGFs to achieve sustained drug release. The prepared HGFs embedding of berberine nanosuspension was characterized by Fourier transform infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM）, and swelling degree studies. FT-IR revealed that berberine was embedded into the matrix of HGFs, rather than on the surface. SEM showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that HGFs was water absorbing with reversible temperature sensitivity. The drug release study demonstrated that HGFs could be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded HGFs was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.

关键词： Hydrogel PNIAAm Hydrogel grafted fabrics Berberine Nanosuspension wound dressing

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中华疾病控制杂志 2017年第4期21卷 345-348页

作者：查文婷王玲郑剑陈田木罗庆红吕媛湖南师范大学医学院预防医学系湖南长沙410013 中南大学公共卫生学院流行病学教研室湖南长沙410008 长沙市疾病预防控制中心流行病科湖南长沙410004

目的运用地理信息系统(geographic information system,GIS)探索长沙市2006-2013年手足口病的流行病学特征,为实施公共卫生资源的优化配置提供科学依据。方法收集长沙市2006-2013年手足口病相关数据,采用SPSS 18.0和ArcG IS 10.2进行流... 详细信息

目的运用地理信息系统(geographic information system,GIS)探索长沙市2006-2013年手足口病的流行病学特征,为实施公共卫生资源的优化配置提供科学依据。方法收集长沙市2006-2013年手足口病相关数据,采用SPSS 18.0和ArcG IS 10.2进行流行病学特征分析。结果 2006-2013年长沙市手足口病的平均发病率为181.55/10万,主要为5岁以下儿童(95.2%),尤以散居儿童居多(75.1%);2006-2013年发病率总体呈现先升后降的趋势,发病月份主要集中在4~7月(69.8%);从GIS专题地图来看,星沙街道、雨花亭街道、洞井街道、左家塘街道、黎托乡等属于手足口病高发地区;从自相关分析来看,2008-2013年长沙市手足口病发病存在空间聚集性(均有P<0.05),热点区域集中在中部地区;从趋势面分析来看,手足口病发病在空间上呈中间高,四周低的趋势。结论 2006-2013年长沙市手足口病的患者主要为5岁以下散居儿童,发病月份集中在4~7月,发病地点主要是长沙市中部地区,应以此为指导,确定长沙市手足口病的重点防疫人群、时间和区域,实施公共卫生资源的优化配置。

关键词：手足口病疾病特征发病率

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： Yang Zhou yuan-Yan Huang Ding-Yue Shang Ying Chen Meng Tian Cheng-Yu Jin Xin Lu Bing-Chun Yan Han-qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Impact of Coronary Artery Anatomy in Arterial Switch Operation:In-hospital and Post-discharge Outcomes

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Current Medical Science 2022年第3期42卷 642-649页

作者： Shu-yuan WANG qing-yu ZENG Li ZHANG qing lv Ming-xing XIE Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Clinical Research Center for Medical Imaging in Hubei Province Wuhan 430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China Shenzhen Huazhong University of Science and Technology Insititute Shenzhen 518057China

Objective The influence of the coronary artery anatomy on the prognosis of patients receiving an arterial switch operation(ASO)is currently controversial,and the risk factors for this operation may change in more complicated *** study aimed to investigate the influence of coronary artery anomalies on the in-hospital and post-discharge outcomes of ASO in patients with transposition of the great arteries(TGA)and Taussig-Bing anomaly(TBA).Methods We retrospectively reviewed 206 patients who underwent ASO from January 2007 to December *** median age at operation was 33[interquartile range(IQR):20–71]*** follow-up time was 7.2 years(IQR:4.0–10.3 years).Results Coronary anomalies were present in 86 patients(41.7%),with 9(4.4%)of them having a single coronary *** coronary features included intramural courses in 5(2.4%)patients,ostial stenosis in 1(0.5%)patient,and accessory coronary artery orifices in 5(2.4%)*** were 32(15.5%)in-hospital deaths and 8(4.6%)post-discharge deaths,yielding an overall survival of 81.3%,80.7%and 79.9%at 1,5 and 10 years,*** due to ASO has been drastically decreased since *** with a single coronary artery had higher rate of in-hospital mortality,but this finding was not statistically *** earlier surgical era(OR:2.756)and a longer cardiopulmonary bypass time(OR:2.336)were significantly associated with in-hospital mortality,while coronary patterns were *** intramural coronary artery(HR:10.034)and a patient age of older than 1 year at the time of ASO(HR:9.706)were independent predictors of post-discharge *** ASO remains the procedure of choice for TGA with coronary anomalies with acceptable in-hospital and post-discharge outcomes in terms of overall survival and freedom of ***,intramural coronary artery is an independent risk factor for post-discharge *** surgery within the 1st year of life helps improve overall m

关键词： congenital heart disease complex coronary artery early mortality late mortality learning curve

Mesh Deformation Method Based on Mean Value Coordinates Interpolation

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Acta Mechanica Solida Sinica 2016年第1期29卷 1-12页

作者： Shuli Sun Shuming lv yuan yuan Mingwu yuan LTCS Department of Mechanics and Engineering ScienceCollege of EngineeringPeking University

Mesh deformation technique is widely used in many application fields, and has re- ceived a lot of attentions in recent years. This paper focuses on the methodology and algorithm of algebraic type mesh deformation for unstructured mesh in numerical discretization. To preserve mesh quality effectively, an algebraic approach for two and three dimensional unstructured mesh is developed based on mean value coordinates interpolation combined with node visibility analysis. The proposed approach firstly performs node visibility analysis to find out the visible boundary for each grid point to be moved, then evaluates the mean value coordinates of each grid point with respect to all vertices on its visible boundary. Thus the displacements of grid points can be calculated by interpolating the boundary movement by the mean value coordinates. Compared with other methods, the proposed method has good deformation capability and predictable com- putational cost, with no need to select parameters or functions. Applications of mesh deformation in different fields are presented to demonstrate the effectiveness of the proposed approach. The results of numerical experiments exhibit not only superior deformation capability of the method in traditional applications of fluid dynamic grid, but also great potential in modeling for large deformation analysis and inverse design problems.

关键词： unstructured mesh mesh deformation mean value coordinates (MVC) visibilityanalysis domain partition

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Frontiers of Information Technology & Electronic Engineering 2017年第6期18卷 796-807页

作者： Zhen-hua yuan Chen CHEN Xiang CHENG Guo-cheng lv Liu-qing YANG Ye JIN State Key Laboratory of Advanced Optical Communication Systems and Networks Peking University Department of Electrical & Computer Engineering Colorado State University

This article is focused on secure relay beamformer design with a correlated channel model in the relay-eavesdropper network. In this network, a single-antenna source-destination pair transmits secure information with the help of an amplify-and-forward (AF) relay equipped with multiple antennas, and the legitimate and eavesdropping channels are correlated. The relay cannot obtain the instantaneous channel state information (CSI) of the eavesdropper, and has only the knowledge of correlation information between the legitimate and eavesdropping channels. Depending on this information, we derive the conditional distribution of the eavesdropping channel. Two beamformers at the relay are studied for the approximate ergodic secrecy rate:(1) the generalized match-andforward (GMF) beamformer to maximize the legitimate channel rate, and (2) the general-rank beamformer (GRBF).In addition, one lower-bound-maximizing (LBM) beamformer at the relay is discussed for maximizing the lower bound of the ergodic secrecy rate. We find that the GMF beamformer is the optimal rank-one beamformer, that the GRBF is the iteratively optimal beamformer, and that the performance of the LBM beamformer for the ergodic secrecy rate gets close to that of the GRBF for the approximate secrecy rate. It can also be observed that when the relay has lower power or the channel gain of the second hop is low, the performance of the GMF beamformer surpasses that of the GRBF. Numerical results are presented to illustrate the beamformers' performance.

关键词： Physical layer security Relay beamforming Correlated channels Ergodic secrecy rate

Application of the concept of continuous dopaminergic stimulation for the management of Parkinson's disease

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Neuroscience Bulletin 2013年第5期29卷 661-669页

作者： qing lv Baorong Zhang Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University

Continuous dopaminergic stimulation（CDS）is a prominent therapeutic concept for the treatment of Parkinson＇s disease（PD）,which proposes that continuous brain dopamine-receptor stimulation,rather than intermittent doses of oral L-dopa,prevents or manages L-dopa-induced dyskinesias（LIDs）.In the normal situation,dopaminergic neurons in the substantia nigra pars compacta fire tonically to keep the dopamine receptor stimulation at a steady-state *** when the dopaminergic pathway is impaired,the dopamine receptor stimulation becomes intermittent or *** pulsatile stimulation causes a series of gene and protein changes in striatal neurons,leading to alterations in the firing patterns of basal ganglia neurons that result in *** in animal models and clinical trials of PD have shown that approaches providing CDS,currently including patches,extended-release formulations of L-dopa or dopamine agonists,continuous delivery of apomorphine and duodenal L-dopa infusion,are associated with a decreased risk of *** this review,we summarize both preclinical and clinical evidence for the five methods that may provide CDS in theory and compare the advantages and disadvantages of these methods.

关键词： continuous dopaminergic stimulation application Parkinson's disease L-dopa-induced dyskinesias

Fabrication of combustion pyrotechnics for laser and electromagnetic interference shielding

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Defence Technology（防务技术） 2023年第6期24卷 140-147页

作者： yuan-yuan Yao Shao-hua Jin Jing Huang Dong-ze Li Bo-lin Xu Xi-juan lv qing-hai Shu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China School of Physics Beijing Institute of TechnologyBeijing100081China Beijing Institute of Electronic System Engineering Beijing100854China State-owned Changhong Machinery Factory Guilin541002China

The contradiction between flammability and packing density is the technical bottleneck for combustible smoke ***,polyurethane(PU)foams with flammability and resilience were prepared with polyol and isocyanate as raw materials by chemical foaming method,then compounded with metal powders,polytetrafluoroethylene(PTFE),phthalic annychide(PA),*** a certain proportion and pressed into pyrotechnic grain to obtain eco-friendly combustion aerosols with compact density of about1.15 g/cm^(3).The resulting combustion smoke agent combined the advantages of PU foam and pyrotechnic with easy ignition,large smoke production,long duration and low environmental *** transmittance of aerosols for 532 nm and 1064 nm lasers was close to 0,and the EMI SE reached up to65 d B and 35 d B in GPS band and X band,*** addition,the resulting pyrotechnic grains exhibited good mechanical strength and elasticity for sample 1:25,with a compressive strength of22 MPa and an elastic modulus of 195 *** resulting combustion smoke agent is expected to play a potential role in the field of electromagnetic damage and protection.

关键词： Smoke agent Flammability PU foam Laser masking EMI shielding

First-principles study on superconductive properties of compressive strain-engineered cryogenic superconducting heavy metal lead(Pb)

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Communications in Theoretical Physics 2021年第3期73卷 156-161页

作者： qing-yuan Chen School of Physical Science and Technology Kunming UniversityKunming650214China

As one of the main materials in the practical *** superconductor,lead(Pb)has been used to manufacture superconducting AC power cable,and some weak current *** the development of manufacturing,technology,more and more researchers focus on exploring the physical and chemical properties of cryogenic superconducting materials,instead of blindly pursuing the improvement of the superconducting transition temperature(T_(c)).In this paper,the structural properties and superconducting transition temperature under high pressure of Pb have been studied by first-principles *** has shown that Pb can withstand the compressive strain up to 10%while the lattice structure remains stable,indicated by the calculations of phonon band *** 0%to 10%compressive strain,there is neither a band-gap nor changing of the band *** of electronic *** the Fermi level leads to a decreasing of T_(c).Our calculations show that Pb is a stable elemental metallic superconductor even under high pressure,which explains the reason why it has been used in practical productions.

关键词： first-principles study superconductive properties strain Pb