Fast dissolving film containing nanoparticles:a novel solidified strategy for drug nanosuspensions
作者单位：302 Hospital of PLA&PLA Institute of Chinese Materia Medica School of ScienceMonmouth UniversityWest Long Branch
会议名称：《“好医生杯”中药制剂创新与发展论坛》
会议日期：2013年
学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
基 金：the financial support from the Natural Science Found of Beijing city of China(No.7122176) the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry(No.20101561) the National Key New Drugs Innovation Foundation(No.2013ZX09J13109-06C)
关 键 词：Nanosuspensions High pressure homogenization Fast dissolving films Film casting
摘 要：In this study,a novel fast dissolving film containing drug nanoparticles was developed with the goal of transforming drug nanosuspensions into a solid *** wereprepared by high pressure homogenization and then transformed into fast dissolving film containing drug nanoparticles by film ***(HPE),a novel and potent antiviral agent with poor water solubility that extracted from Herpetospermum caudigerum,was chosen as a model drug and studied *** uniformity of dosage units of the preparation was acceptable according to the criteria of Chinese Pharmacopoeia *** fast dissolving film was disintegrated in water within 30 s with reconstituted nanosuspensions particle size of 280.69±11.57 nm,which was similar to that of drug nanosuspensions,indicating a good redispersibility of the fast dissolving *** of X-ray diffraction showed that HPE in the fast dissolving film was in the amorphous *** the in vitro dissolution test,the fast dissolving film containing HPE nanoparticles showed an increased dissolution velocity *** result revealed that the fast dissolving film containing drug nanoparticles may provide a potential opportunity in transforming drug nanosuspensions into a solid dosage form as well as enhancing the dissolution rate of poorly water-soluble drugs.