Poly（N-isopropylacrylamide）/alginate Copolymer Hydrogel Grafted Fabrics Embedding of Berberine Nanosuspension: Preparation Evaluation in Vitro and in Vivo
作者单位：Department of Pharmacy 302 Military Hospital of China School of Pharmacy Chengdu University of Traditional Chinese Medicine School of Science Monmouth University Institute of Tuberculosis 309 Military Hospital of China
会议名称：《2013年中国药学大会暨第十三届中国药师周》
会议日期：2013年
学科分类：1007[医学-药学(可授医学、理学学位)] 081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070305[理学-高分子化学与物理] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学]
基 金：financially supported by National Key New Drugs Innovation Foundation(2012ZX09J12108-04C,2011ZX09201-201-35,CWS11J165) Beijing Natural ScienceFoundation of China(7122176)
关 键 词：Hydrogel PNIAAm Hydrogel grafted fabrics Berberine Nanosuspension wound dressing
摘 要：In the present studies, a novel hydrogel-grafted fabrics embedding of berberine nanosuspension was developed for the treatment of infected wound. Hydrogel-grafted fabrics （HGFs） was prepared by graft copolymerization of N-isopropylacrylamide （NIAAm） and alginate using ceric ammonium nitrate as initiator. Berberine nanosuspension was prepared and embedded in the HGFs to achieve sustained drug release. The prepared HGFs embedding of berberine nanosuspension was characterized by Fourier transform infrared spectroscopy （FT-IR）, scanning electron microscopy （SEM）, and swelling degree studies. FT-IR revealed that berberine was embedded into the matrix of HGFs, rather than on the surface. SEM showed that a thin hydrogel layer was formed on the surface of nonwoven fibers. The swelling study showed that HGFs was water absorbing with reversible temperature sensitivity. The drug release study demonstrated that HGFs could be used as a sustained drug delivery system of hydrophobic compounds. The berberine nanosuspension embedded HGFs was further investigated in an animal infected wound model and was found to be a very promising wound healing dressing for the treatment and healing of infected wounds.