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Recent Strategies and Advances in hydrogel‑Based Delivery Platforms for Bone Regeneration

Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang Jia Zeng Donglin Gan Kun Ling Mingfang He Jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou Zhang Shuo Li Fu Tang Jingkai Zhang Yuetong Kang Hean Zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial

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Recent advances of hydrogel network models for studies on mechanical behaviors

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Acta Mechanica Sinica 2021年第3期37卷 367-386,I0001页

作者： Jincheng Lei Ziqian Li Shuai Xu Zishun Liu International Center for Applied Mechanics State Key Laboratory for Strength and Vibration of Mechanical StructuresXi'an Jiaotong UniversityXi'an 710049China

Current constitutive theories face challenges when predicting the extremely large deformation and fracture of hydrogels,which calls for the demands to reveal the fundamental mechanism of the various mechanical behaviors of hydrogels from bottom *** hydrogel network model provides a better approach to bridge the gap between the micro-structure and the macroscopic mechanical *** work summarizes the theoretical and numerical researches on the hydrogel network models,aiming to provide new insights into the effect of microstructure on the swelling-deswelling process,hyperelasticity,viscoelasticity and fracture of *** network models are divided into full-atom network models,realistic network models and abstract network ***-atom network models have detailed atomic structure but small *** network models with different coarse-graining degree have large model size to explain the swelling-deswelling process,hyperelasticity and *** network models abstract polymer chains into analytical interactions,leading to the great leap of model *** shows advantages to reproduce the crack initiation and propagation in hydrogels by simulating chain *** research directions on the network modeling are *** hope this work can help integrate the merits of network modeling methods and continuum mechanics to capture the various mechanical behaviors of hydrogels.

关键词： hydrogel Polymer network Mechanical behavior Fracture

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hydrogel-based catalysts for hydrogen generation by the hydrolysis of B–H compounds under external physical fields

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Journal of Energy Chemistry 2023年第11期86卷 518-535,I0011页

作者： Chunling Qin Wenliu Wu Hassanien Gomaa Shuai Wu Cuihua An Qibo Deng Ning Hu Key Laboratory of Hebei Province on Scale-span Intelligent Equipment Technology School of Mechanical Engineeringand School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China State Key Laboratory of Reliability and Intelligence Electrical Equipment Hebei University of TechnologyTianjin 300130China Advanced Equipment Research Institute Co. Ltd.Of HEBUTTianjin 300401China

Hydrogen is a popular clean high-energy-density ***,its utilization is limited by the challenges toward low-cost hydrogen production and safe hydrogen ***,these issues can be addressed using promising hydrogen storage materials such as B–H *** stored in B–H compounds can be released by hydrolysis at room temperature,which requires catalysts to increase the rate of the ***,several effective approaches have been developed for hydrogen generation by catalyzing the hydrolysis of B–H *** review summarizes the existing research on the use of nanoparticles loaded on hydrogels as catalysts for the hydrolysis of B–H ***,the factors affecting the hydrolysis rate,such as temperature,p H,reactant concentration,and type of nano particles,were ***,the preparation methods(in situ reduction,one-pot method,template adsorption,etc.)for the hydrogel catalysts and the types of loaded catalysts were ***,the hydrogel catalysts that can respond to magnetic fields,ultrasound fields,optical fields,and other physical fields are ***,the issues and future developments of hydrogel-based catalysts are *** review can inspire deeper investigations and provide guidance for the study of hydrogel catalysts in the field of hydrogen production via hydrolysis.

关键词： hydrogel Nanoparticlec atalyst B-H compounds Hydrolysis reaction External physical field

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hydrogel-derived nitrogen-doped porous carbon framework with vanadium nitride decoration for supercapacitors with superior cycling performance

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Journal of Materials Science & Technology 2023年第24期155卷 167-174页

作者： Ziqiang Wu Qian Chen Changdian Li Lili Zhu Yanan Huang Xiaoguang Zhu Xuebin Zhu Yuping Sun Key Laboratory of Materials Physics Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 China University of Science and Technology of China Hefei 230026 China High Magnetic Field Laboratory HFIPS Chinese Academy of Sciences Hefei 230031 China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China

Transition metal nitrides(TMNs)and their composites with carbon materials hold tremendous potential for supercapacitor(SC)electrodes because of their excellent electronic conductivity and electrochemical ***,realizing cycling stable TMN/carbon-based supercapacitors with economically viable and environmentally-friendly approaches remains a significant ***,polyacrylamide(PAM)hydrogel,as a water-soluble linear polymer electrolyte,is expected to be a remarkable candidate precursor for preparing N-doped porous carbon(NPC)due to the high contents of carbon and nitrogen *** this study,vanadium nitride(VN)embedded in PAM hydrogel-derived NPC was fabricated successfully via an ammonia-free *** VN/NPC delivers a high specific capacitance of 198.3 F g^(−1)at a current density of 1 A g^(−1),with a remarkable cycling stability of 107%after 16,000 *** electrochemical performances of VN/NPC compared to bare VN nanoparticles are strongly improved due to the composite ***,the VN/NPC-based solid-state symmetric device delivers an excellent energy density of 21.97µWh cm^(−2)at a power density of 0.5 mW cm^(−2),and an outstanding cycling durability of 90.9%after 18,000 *** work paves the way to design metal nitride/porous carbon materials,which also opens up unique horizons for the recovery of hydrogel electrolyte.

关键词： Vanadium nitride Nitrogen-doped porous carbon Polyacrylamide hydrogel Supercapacitor

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Synthesis and characterization of hydrogel bonded with rare earth

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Journal of Rare Earths 2008年第5期26卷 660-663页

作者：严长浩焦联联郭春芳张明邱关明 College of Materials Science and Engineering Nanjing University of Technology College of Chemistry & Chemical Engineering Yang- zhou University School of Materials and Engineering Changchun University of Science and Engineering

Chitosan-poly（acryfic acid） hydrogel bonded with Eu^3＋ was prepared by radical solution polymerization. Biodegradable chitosan, N,N＇-methylen-diacrylamide, and potassium persulphate were used as the basic material, cross-linking agent, and initiator, respectively. The structure and thermal property of hydrogel were characterized by infrared spectrometry, X-ray diffraction, scanning electron microscopy, and differential scanning calorimetry. The swollen property and fluorescent performance were also characterized. The results showed that the rare earth presented unique distribution in the hydrogel due to the formation of chemical bonds after polymerization. The glass transition temperature of the hydrogel decreased remarkably, which might broaden the range of its elastic application considerably. Moreover, the characteristic fluorescent emission of Eu^3＋ was observed in the hydrogel, which was indicative of the excellent luminescent performance.

关键词： hydrogel chitosan acrylic acid fluorescence rare earths

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hydrogel-exosome system in tissue engineering:A promising therapeutic strategy

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Bioactive Materials 2024年第8期38卷 1-30页

作者： Ming-Hui Fan Jin-Kui Pi Chen-Yu Zou Yan-Lin Jiang Qian-Jin Li Xiu-Zhen Zhang Fei Xing Rong Nie Chen Han Hui-Qi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041PR China Core Facilities West China HospitalSichuan UniversityChengduSichuan610041PR China Frontier Medical Center Tianfu Jincheng LaboratoryChengduSichuan610212PR China

Characterized by their pivotal roles in cell-to-cell communication,cell proliferation,and immune regulation during tissue repair,exosomes have emerged as a promising avenue for“cell-free therapy”in clinical ***,possessing commendable biocompatibility,degradability,adjustability,and physical properties akin to biological tissues,have also found extensive utility in tissue engineering and regenerative *** synergistic combination of exosomes and hydrogels holds the potential not only to enhance the efficiency of exosomes but also to collaboratively advance the tissue repair *** review has summarized the advancements made over the past decade in the research of hydrogel-exosome systems for regenerating various tissues including skin,bone,cartilage,nerves and tendons,with a focus on the methods for encapsulating and releasing exosomes within the *** has also critically examined the gaps and limitations in current research,whilst proposed future directions and potential applications of this innovative approach.

关键词： Exosome hydrogel Tissue engineering Regenerative medicine

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hydrogel Microneedle Arrays for Transdermal Drug Delivery

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Nano-Micro Letters 2014年第3期6卷 191-199页

作者： Xiaoyun Hong Zaozhan Wu Lizhu Chen Fei Wu Liangming Wei Weien Yuan School of Pharmacy Shanghai Jiao Tong University Research Institute of Micro/Nano Science and Technology Shanghai Jiao Tong University

Stratum corneum is the main obstacle for drugs to pass through the skin. Microneedles are composed of arrays of micro-projections formed with different materials, generally ranging from 25-2000 μm in height. Microneedles straightly pierce the skin with its short needle arrays to overcome this barrier. Microneedles can be divided into several categories, for instance, solid microneedles, coated microneedles, and hollow microneedles and so on. However, all these types have their weak points related to corresponding *** recent years, pioneering scientists have been working on these issues and some possible solutions have been investigated. This article will focus on the microneedle arrays consisting of hydrogels. hydrogels are commonly used in drug delivery field. hydrogel microneedles can be further divided into dissolving and degradable microneedles and phase transition microneedles. The former leaves drug with matrix in the skin. The latter has the feature that drugs in the matrix are delivered while the remaining ingredients can be easily removed from the skin after usage. For drugs which are required to be used every day, the phase transition microneedles are more acceptable. This article is written in order to summarize the advantages of these designs and summarize issues to be solved which may hinder the development of this technology.

关键词： hydrogel Microneedle Phase transition Dissolving and degradable

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hydrogel platform with tunable stiffness based on magnetic nanoparticles cross-linked GelMA for cartilage regeneration and its intrinsic biomechanism

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Bioactive Materials 2023年第7期25卷 615-628页

作者： Chenchen Zhou Chunli Wang Kang Xu Zhixing Niu Shujuan Zou Demao Zhang Zhiyong Qian Jinfeng Liao Jing Xie State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengdu610041China State Key Laboratory of Biotherapy State Key Laboratory and Collaborative Innovation Center of BiotherapyWest China HospitalSichuan UniversityChengdu610041SichuanChina "111"Project Laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing UniversityChongqing400044China College of Pharmacy Hubei University of Chinese MedicineWuhan430065China Department of Cardiology and Endodontics West China Hospital of StomatologySichuan UniversityChengduSichuan610064China

Cartilage injury affects numerous individuals,but the efficient repair of damaged cartilage is still a problem in *** is a potent scaffold candidate for tissue regeneration,but it remains a big challenge to improve its mechanical property and figure out the interaction of chondrocytes and ***,a novel hybrid hydrogel with tunable stiffness was fabricated based on methacrylated gelatin(GelMA)and iron oxide nanoparticles(Fe_(2)O_(3))through chemical *** stiffness of Fe_(2)O_(3)/GelMA hybrid hydrogel was controlled by adjusting the concentration of magnetic *** hydrogel platform with tunable stiffness modulated its cellular properties including cell morphology,microfilaments and Young’s modulus of ***,Fe_(2)O_(3)/GelMA hybrid hydrogel promoted oxidative phosphorylation of mitochondria and facilitated catabolism of lipids in *** a result,more ATP and metabolic materials generated for cellular physiological activities and organelle component replacements in hybrid hydrogel group compared to pure GelMA ***,implantation of Fe_(2)O_(3)/GelMA hybrid hydrogel in the cartilage defect rat model verified its remodeling *** study provides a deep understanding of the bio-mechanism of Fe_(2)O_(3)/GelMA hybrid hydrogel interaction with chondrocytes and indicates the hydrogel platform for further application in tissue engineering.

关键词： Magnetic nanoparticles hydrogel Chondrocyte Cartilage defect Cellular metabolism

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Near-field electrospun PCL fibers/GelMA hydrogel composite dressing with controlled deferoxamine-release ability and retiform surface for diabetic wound healing

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Nano Research 2023年第1期16卷 599-612页

作者： Huiling Zhong Jun Huang Moucheng Luo Yifei Fang Xinchen Zeng Jun Wu Jianhang Du Medical Research Center The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518033China School of Biomedical Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China Department of Liver Surgery The Third People’s Hospital of ShenzhenShenzhen 518112China NHC Key Laboratory of Assisted Circulation Sun Yat-sen UniversityGuangzhou 510080China

Wound ulceration caused by diabetes is a typical chronic wound wherein healing the local tissue is difficult due to lack of blood vessels and tissue necrosis caused by the long-term accumulation of free ***-field electrospinning(NFES)is an innovative technology used to produce micro-nano-scaled,controllable sequencing *** this study,we constructed a novel wound dressing based on the NFES polycaprolactone(PCL)fiber network and modified gelatin with methacrylic anhydride(GelMA)hydrogel to promote angiogenesis and the re-epithelialization of diabetic *** angiogenic and antioxidant drug named deferoxamine(DFO)was encapsulated in a GelMA hydrogel to achieve a slow-release effect that is more suitable for chronic *** cell adhesion experiment showed that the cells could attach to the fibers in the dressing group having a network of PCL fibers on the surface and grow along the direction of the fibers,which in turn,effectively regulates cell behavior from the physical ***,the large pore size(~500μm)of the network allowed the cells to penetrate the pores and enter the surface of the hydrogel without being blocked ***,the composite dressing had a notable effect on ***,antioxidation experiments confirmed that the DFO-loaded hydrogel exhibited antioxidant *** animal models of diabetes showed that rats treated with the PCL-GelMA-DFO(PGD)hydrogel had faster ability of hemostasis,scab formation,and wound *** conclusion,the PGD hydrogel effectively promoted the repair of chronic wounds.

关键词： diabetic wound healing near field electrospinning hydrogel large pore

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