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黄芩炒炭过程中主要成分与色度值的变化规律及其止血作用研究

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中草药 2024年第15期55卷 5083-5092页

作者：乔瑞瑞刘硕白亚亚赵重博史亚军张丽唐于平张桥孙静陕西中医药大学药学院陕西西安712046 南京中医药大学翰林学院江苏泰州225300

目的通过分析黄芩Scutellariae Radix炒炭过程中化学成分与色度值的动态变化规律及其止血作用评价,以期为黄芩炒炭过程中的质量控制提供科学依据,同时为黄芩炒炭终点的判断奠定基础。方法制备不同炮制程度的黄芩炭样品(H1~H10),采用紫外... 详细信息

目的通过分析黄芩Scutellariae Radix炒炭过程中化学成分与色度值的动态变化规律及其止血作用评价,以期为黄芩炒炭过程中的质量控制提供科学依据,同时为黄芩炒炭终点的判断奠定基础。方法制备不同炮制程度的黄芩炭样品(H1~H10),采用紫外-可见分光光度法测定不同炮制程度黄芩炭样品的总黄酮含量和炭吸附力;采用HPLC法测定不同炮制程度黄芩炭样品中没食子酸、5-羟甲基糠醛、野黄芩苷、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素及千层纸素A含量;采用分光测色仪测定不同炮制程度黄芩炭样品的L^(*)(亮度值)、a^(*)(红绿色值)、b^(*)(黄蓝色值)、E_(ab)^(*)(总色值);采用SPSS 19.0和SIMCA 14.1软件进行颜色与主要成分的关联分析。最后,采用剪尾法及玻片法进行不同炮制程度黄芩炭样品对正常小鼠止血及凝血时间的药效评价。结果在黄芩炭炮制过程中,随着炭化程度的增加,样品中总黄酮、没食子酸、5-羟甲基糠醛、黄芩苷、汉黄芩苷、黄芩素、汉黄芩素、千层纸素A的含量呈先增后降的趋势,野黄芩苷呈下降趋势。样品粉末的L^(*)、b^(*)、E_(ab)^(*)值呈降低趋势,a^(*)值呈先增后降趋势。L^(*)值、b^(*)值和E_(ab)^(*)值与野黄芩苷、黄芩苷、汉黄芩苷呈正相关,a^(*)值与没食子酸、5-羟甲基糠醛、黄芩素、汉黄芩素、千层纸素A呈正相关,总黄酮与L^(*)、a^(*)、b^(*)、E_(ab)^(*)呈正相关。主成分分析(principal component analysis,PCA)结果显示,不同炮制程度黄芩炭样品各自归类成簇,可区分不同程度的炮制品。回归分析显示,仅没食子酸、5-羟甲基糠醛、汉黄芩素可通过色度值结合回归方程来预测含量,其余成分则不能。结合PCA、炭吸附力及药理实验结果表明,黄芩炭炮制前后炭吸附力和止血、凝血作用差异较大,样品H7(180℃、9 min)炭吸附力作用较强,结合止血及凝血时间,H7样品止血作用较好。结论黄芩炒炭过程中的颜色与化学成分的变化存在相关性,可为黄芩炒炭终点判断提供数据支撑。

关键词：黄芩炭化学成分色度值炭吸附力止血作用黄酮没食子酸 5-羟甲基糠醛野黄芩苷黄芩苷汉黄芩苷黄芩素汉黄芩素千层纸素A 主成分分析

Liquid Metal Particles and Polymers: A Soft−Soft System with Exciting Properties

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Accounts of Materials Research 2021年第10期2卷 966-978页

作者： Shi-Yang Tang ruirui qiao Department of Electronic Electrical and Systems EngineeringUniversity of BirminghamBirmingham B152TTU.K. Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQLD 4072Australia

CONSPECTUS:Gallium-based liquid metal alloys are a special type of material that is in the liquid state at(or near)room *** are particularly attractive due to their unique combination of a fluidic and metallic body,together with a chemically reactive and functionable *** a fluid,liquid metals provide the best union of stretchability,deformability,and electrical conductivity among all soft *** an advantage in combination with their low toxicity and relatively good biocompatibility have imparted liquid metals with unique features that can be harnessed for versatile applications in fields such as electronics,energy,chemistry,and biomedical *** importantly,the fluidic nature of liquid metals allows them to be readily processed using shear for making particles with variable sizes(from nm to mm),which is not possible with solid *** particles have a liquid metal core−solid metal oxide shell(conductor−semiconductor)structure,allowing them to merge,transform shape,change phase,respond to stimuli,and self-heal.

关键词： materials. temperature. metals

Resorbable polymer electrospun nanofibers:History,shapes and application for tissue engineering

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Chinese Chemical Letters 2020年第3期31卷 617-625页

作者： Tingting Wu Mengzhen Ding Cuiping Shi Yiqun qiao Panpan Wang ruirui qiao Xichang Wang Jian Zhong National R&D Branch Center for Freshwater Aquatic Products Processing Technology(Shanghai) Integrated Scientific Research Base on Comprehensive Utilization Technology for By-Products of Aquatic Product ProcessingMinistry of Agriculture and Rural Affairs of the People's Republic of ChinaShanghai Engineering Research Center of Aquatic-Product Processing and PreservationCollege of Food Science&TechnologyShanghai Ocean UniversityShanghai 201306China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash UniversityParkvilleVIC 3052Australia

Resorbable polymer electrospun nanofiber-based materials/devices have high surface-to-volume ratio and often have a porous structure with excellent pore interconnectivity,which are suitable for growth and development of different types of *** to the huge advantages of both resorbable polymers and electrospun nano fibers,re sorbable polymer electrospun nanofibers(RPENs)have been widely applied in the field of tissue *** this paper,we will mainly introduce RPENs for tissue ***,the electrospinning technique and electrospun nanofiber architectures are briefly ***,the application of RPENs in the field of tissue engineering is mainly ***,the advantages and disadvantages of RPENs for tissue engineering are *** review will provide a comprehensive guide to apply resorbable polymer electrospun nanofibers for tissue engineering.

关键词： Architechture Electrospinning Nanofiber Resorbable polymer Tissue engineering

A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

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Nano Research 2020年第8期13卷 2216-2225页

作者： Hongwei Lu Yongjing Xu ruirui qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming Zou Zhongling Wang Department of Radiology Shanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Gastroenterology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of ***,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic *** polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO ***,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer ***,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from *** showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser *** results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.

关键词： theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect

Polymer-based synthetic oncolytic virus-like nanoparticles for cancer immunotherapy

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Science China Chemistry 2023年第12期66卷 3576-3586页

作者： Yuxi Gao Hanqin Zhao Jiayu Zhao Sheng Ma Xinghui Si Liping Liu ruirui qiao Wantong Song Xuesi Chen State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China Australian Institute of Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueensland 4072Australia Jilin Biomedical Polymers Engineering Laboratory Changchun 130022China

Oncolytic viruses have emerged as new powerful therapeutic agents for cancer therapy by specifically lysing cancer cells while activating innate immune responses at the same ***,due to the thorny issues of safety concerns and host immune reaction,the clinical application of oncolytic viruses is still ***,we report a rationally designed oncolytic virus-like nanoparticles(OV-NPs)composed of stimulator of interferon genes(STING)-stimulating polymer loaded with therapeutic genes for cancer *** injection into tumor,the OV-NPs carrying OX40L plasmid could reprogram tumor cells to express OX40L immune checkpoint molecules and activate the STING pathway for cooperatively enhancing antitumor immunity,with a tumor suppression rate of 92.3%in B16F10 tumor model and 78.7%in MC38 tumor model without causing any *** OV-NPs could be further applied in carrying other plasmids(IL-12)and utilization in gene combination *** study should inspire designing synthetic OV-NPs as alternative strategies for extending oncolytic virus application in cancer immunotherapy.

关键词： oncolytic virus STING pathway gene delivery nanoparticles bioactive materials

One-pot synthesis of PVP-coated Ni_(0.6)Fe_(2.4)O_4 nanocrystals

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Chinese Science Bulletin 2010年第30期55卷 3472-3478页

作者： LU XianYong NIU Mu YANG ChunHui YI LuoXin qiao ruirui DU MeiHong GAO MingYuan Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China School of Chemistry and Environment Beijing University of Aeronautics and Astronautics Beijing 100191 China Beijing Center for Physical and Chemical Analysis Beijing 100089 China

Novel poly(N-vinyl-2-pyrrolidone) (PVP)-coated nickel ferrite nanocrystals were prepared by simultaneously pyrolyzing nickel(Ⅱ) acetylacetonate (Ni(acac)2) and iron(Ⅲ) acetylacetonate (Fe(acac)3) in N-vinyl-2-pyrrolidone (NVP). The PVP coating was formed in situ through polymerization of NVP. The crystalline structure of the resultant nickel ferrite was analyzed by high-resolution transmission electron microscopy,electron diffraction patterns,and powder X-ray diffraction. In addition,the valence state of Ni and the metal contents of Ni and Fe in different valence states were analyzed by X-ray photoelectron spectroscopy (XPS),atomic absorption and the phenanthroline method. The surface coating layer of PVP and its binding states were characterized by Fourier transform infrared spectroscopy in combination with XPS. Colloidal stability experiments revealed that the nanocrystals could be dispersed well in both phosphate-buffered saline and Dulbecco's Modified Eagle Medium.

关键词：聚乙烯吡咯烷酮高分辨透射电子显微镜纳米涂层 X射线光电子能谱粉末X射线衍射傅里叶变换红外光谱镍铁氧体合成

Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes

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Nano Research 2023年第7期16卷 10034-10046页

作者： Rong Cao Ning Tang Yi Zhu An Chen Yumeng Li Renbin Ge Yuan Li Zhongyi Huang Jiajing Guo Jiali Deng Hongwei Lu Ziwei Lu Helen Forgham Thomas PDavis ruirui qiao Zhongling Wang Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China School of food science Nanjing Xiaozhuang UniversityNanjing 211171China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Neurology School of MedicineNew York UniversityNew York 10016USA Department of Biomedical Engineering College of EngineeringShantou UniversityShantou 515063China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane QLD 4072Australia

The development of microenvironment-responsive nanoprobes has shown great promise for use in magnetic resonance imaging(MRI),with the advantage of significantly improved specificity and good ***,the clinical application of responsive probes is hampered by a lack of biological sensitivity for early molecular diagnostics and visualizing microenvionment of metabolism reprogramming in tumor ***,we report on a dual-ratiometric magnetic resonance tunable(DMRT)nanoprobe designed by crosslinking different ratios of transferrin chelating gadolinium and superparamagnetic nanoparticles,complexed to a pH responsive biocompatible *** dually activatable nanoprobe enables pH-dependent tumor microenvironment visualization,providing exceptional quantitative pathophysiological information in vitro and in *** used in combination with dual-contrast enhancement triple subtraction imaging technique(DETSI),this smart nanoprobe guarantees the diagnosis of early-stage *** envisage that this novel integrated nanoplatform will provide a new paradigm for the clinical translation of robust DMRT nanoprobes for early disease detection and staging,as well as microenvironment visualization and disease progression monitoring.

关键词： ratiometric nanoprobe dually activatable microenvironment visualization early diagnosis pathological changes

胃癌新生血管靶向性双模态分子探针的制备与表征

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中华放射学杂志 2014年第5期48卷 369-374页

作者：康晓伟乔瑞瑞梁树辉吴开春刘先平印弘高明远魏光全第四军医大学西京医院放射科西安710032 中国科学院化学研究所第四军医大学西京消化病医院肿瘤生物学国家重点实验室

目的：构建靶向胃癌新生血管的特异性MR光学双模态分子探针，并初步研究其物理特征、体外细胞毒性及不同脉冲序列的磁化效应。方法将荧光标记的胃癌新生血管靶向性环肽GX1-Cy5.5与表面功能化的磁性纳米颗粒按照不同摩尔质量（1∶100、1... 详细信息

目的：构建靶向胃癌新生血管的特异性MR光学双模态分子探针，并初步研究其物理特征、体外细胞毒性及不同脉冲序列的磁化效应。方法将荧光标记的胃癌新生血管靶向性环肽GX1-Cy5.5与表面功能化的磁性纳米颗粒按照不同摩尔质量（1∶100、1∶500）共价耦合，获得双模态探针DPs100（简称DPs）和DPs500，测定其水合粒径和Zeta电位，并估算偶联结合率。采用二苯基四氮唑溴盐比色（ MTT）法测定DPs对人脐静脉内皮细胞HUVECs和胃癌细胞BGC823活性率的影响。配置不同浓度DPs溶液行MR扫描，观察在不同扫描序列下的相对信号强度（ΔSI ）。不同浓度（0.00、1.25、2.50、15.00、50.00、100.00和150.00μg/ml） DPs处理HUVECs和BGC-823后测得的A值采用单因素方差分析比较；FSE、快速扰相梯度回波（ FSPGR ）和单次激发快速自旋回波（ SSFSE ）序列间ΔSI的比较采用配对资料Wilcoxon符号秩和检验。结果靶向胃癌新生血管双模态探针构建成功。氧化铁颗粒、DPs100和 DPs500的平均水合粒径分别为（35.23±0.07）、（39.49±0.16）和（40.43±1.70）nm；平均Zeta电位分别为（0.31±0.20）、（-4.15±0.79）和（-10.51±2.37） mV。 DPs100和DPs500探针的多肽偶联率分别为92％和94％。不同浓度DPs对HUVECs细胞的A值分别为0.76±0.04、0.80±0.03、0.79±0.05、0.75±0.06、0.74±0.05、0.77±0.01和0.71±0.04，对BGC823细胞的A值分别为0.38±0.04、0.43±0.04、0.41±0.03、0.43±0.07、0.44±0.04、0.41±0.07和0.40±0.04，差异均无统计学意义（F值分别为0.94、0.51，P值均＞0.05）。 T1WI信号强度随DPs浓度的增加先升高后降低，FSPGR T1WI相对信号强度大于FSE T1WI（Z＝-3.294，P＜0.05）；T2WI信号强度随DPs浓度的增大逐渐增加，当DPs＞10μg/ml时，FSE T2 WI与SSFSE T2倡WI相对信号强度差异无统计学意义（Z＝-7.110，P＞0.05）；当DPs≤10μg/ml时，SSFSE T2倡WI较FSE T2WI信号降低更明显（ Z＝-2.023，P＜0.05）。结论双模态分子探针DPs具有很好的稳定性，SSFSE T倡2 WI序列为检测探针最敏感序列。

关键词：胃肿瘤分子探针磁共振成像

胃癌新生血管靶向多功能探针在体MR和光学双模态成像的可行性

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中华放射学杂志 2014年第12期48卷 1038-1043页

目的探讨胃癌新生血管靶向双模态分子探针在体MR和光学双模态成像的可行性.方法将超顺磁性氧化铁纳米颗粒与Cy5.5-CX1耦联合成双模态分子探针DPs,测定探针的水合粒径和Zeta电位.取12只雄性裸鼠,建立胃腺癌皮下移植瘤模型.将12只鼠利... 详细信息

目的探讨胃癌新生血管靶向双模态分子探针在体MR和光学双模态成像的可行性.方法将超顺磁性氧化铁纳米颗粒与Cy5.5-CX1耦联合成双模态分子探针DPs,测定探针的水合粒径和Zeta电位.取12只雄性裸鼠,建立胃腺癌皮下移植瘤模型.将12只鼠利用完全随机设计方法分为实验组与对照组,每组6只,分别通过尾静脉注射相同质量的DPs（实验组）和Fe3O4-Cy5.5（对照组）.于注射前及注射后4、8、12、18、24 h行T2WI,测量肿瘤内信号强度,计算对比噪声比（CNR）,并采用方差分析进行比较.选择2组肿瘤注射前及注射后（12 h）相同层面MR图像,计算信号降低百分比,并采用配对t检验进行比较.实验组和对照组鼠于注射药物后即刻及2、6、20、28、48 h行活体光学成像,观察体内的荧光分布.注射探针48 h后,处死各组实验鼠,分离皮下移植瘤及器官行离体荧光成像和病理检查.结果常温下,Fe3O4-Cy5.5的平均水合粒径为（38.23±0.06）nm,平均Zeta电位为（0.29±0.16）mV;DPs的平均水合粒径为（39.49±0.16）nm,平均Zeta电位为（-4.15±0.79）mV.酶标仪检测偶联阳性率＞90％.实验组与对照组的肝、脾等网状吞噬系统MRI信号降低显著.实验组注射前及注射后4、8、12、18、24 h小鼠肿瘤的CNR分别为18.27±2.19、18.40±2.00、10.22±1.97、9.25±0.44、20.28±1.46和22.41±1.71,差异有统计学意义（F值=49.55,P＜0.01）,在注射探针后8、12 h CNR较注射前明显降低;对照组上述时间小鼠肿瘤的CNR分别为13.52±1.05、11.38±1.28、13.03±1.38、12.89±1.20、12.06±0.81和13.58±1.74,差异无统计学意义（F值=2.306,P＞0.05）.实验组肿瘤最外围信号降低百分比为（33.0±2.7）％,中央带为（22.0±1.6）％;对照组最外围信号降低百分比为（8.3±1.2）％,中央带为（3.8±0.9）％,2组肿瘤最外围的信号降低均比中央层显著,差异均有统计学意义（t值分别为-7.872和6.678,P均＜0.01）.实验组在注射探针后2～48 h肿瘤的荧光强度明显高于背景,对照组肿瘤与背景荧光强度差别不明显.离体组织显示荧光主要分布在肿瘤和肺脏.病理示肿瘤新生血管主要分布于肿瘤周边区域.实验组肿瘤内散在蓝染颗粒,实验组肾脏与对照组肾脏、肿瘤未见蓝染铁颗粒显示.结论 DPs可选择性聚集于胃癌,可用于MR光学双模态成像技术进行检测.

关键词：胃肿瘤分子探针磁共振成像