A novel clustered SPIO nanoplatform with enhanced magnetic resonance T2 relaxation rate for micro-tumor detection and photothermal synergistic therapy

作     者：Hongwei Lu Yongjing Xu Ruirui Qiao Ziwei Lu Pin Wang Xindan Zhang An Chen Liming Zou Zhongling Wang Hongwei Lu;Yongjing Xu;Ruirui Qiao;Ziwei Lu;Pin Wang;Xindan Zhang;An Chen;Liming Zou;Zhongling Wang

作者机构：Department of RadiologyShanghai General HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai200080China State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai201620China ARC Centre of Excellence in Convergent Bio-Nano Science and TechnologyMonash Institute of Pharmaceutical SciencesMonash University381 Royal ParadeParkvilleVIC3052Australia Department of RadiologyThe First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of GastroenterologyNanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjing210029China Department of Materials Science and EngineeringSouthern University of Science and TechnologyShenzhen518055China 

出 版 物：《Nano Research》 (纳米研究（英文版）)

年 卷 期：2020年第13卷第8期

页      面：2216-2225页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：This work was supported by National Natural Science Foundation of China(No.81971664) Shanghai Pujang Program(2019PJD044) National Key Research and Development Project of China(2016YFB0303200) Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support 

主　　题：theranostic agent clustered SPIO nanoplatform T2 MRI micro-tumor detection photothermal therapy synergetic effect 

摘      要：Construction of micro tumor sensitive theranostic nanoagents that can increase the accuracy of imaging diagnosis and boost the therapeutic efficacy has been demonstrated for a promising approach for diagnosis and treatment of ***,we reported a novel super-paramagnetic iron oxide(SPIO)based nanoplatform that possess significantly enhanced magnetic resonance property and photothermal effect for tumor theranostic *** polyethylene glycol with four phenylboronic acid(PEG-B4)/CNTs@porphyrin(ph)/SPIO(BCPS)nanoplatform was simply prepared via integrated SPIO,ph,and a novel dendrimer with PEG liner and four PBA groups(PEG-B4)on the surface of carbon nanotubes(CNTs).Subsequently,a significant T2 relaxation rate enhanced can be achieved by the reduced accessibility of water to SPIO ***,the synergetic enhanced photothermal from BCPS nanoplatform contributed to better photothermal effect for cancer ***,the targeting ability to sialic acid overexpressed tumor was further introduced from phenylboronic acid from *** showed that BCPS nanoplatform could not only selectively identify solid tumors and detect micro-sized metastatic tumor(1 mm)in the liver,but also effectively ablate tumors in a xenograft model,thereby achieving a complete cure rate of 100%at low laser *** results highlight the potential of BCPS nanoplatform for accurate micro-tumor diagnosis and effective tumor therapy.