Polymer-based synthetic oncolytic virus-like nanoparticles for cancer immunotherapy

作     者：Yuxi Gao Hanqin Zhao Jiayu Zhao Sheng Ma Xinghui Si Liping Liu Ruirui Qiao Wantong Song Xuesi Chen Yuxi Gao;Hanqin Zhao;Jiayu Zhao;Sheng Ma;Xinghui Si;Liping Liu;Ruirui Qiao;Wantong Song;Xuesi Chen

作者机构：State Key Laboratory of Supramolecular Structure and MaterialsCollege of ChemistryJilin UniversityChangchun 130012China Key Laboratory of Polymer EcomaterialsChangchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and EngineeringUniversity of Science and Technology of ChinaHefei 230026China Australian Institute of Bioengineering and NanotechnologyThe University of QueenslandBrisbaneQueensland 4072Australia Jilin Biomedical Polymers Engineering LaboratoryChangchun 130022China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2023年第66卷第12期

页      面：3576-3586页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 10[医学] 0702[理学-物理学] 

基　　金：supported by the National Natural Science Foundation of China (22222509,52025035,51973215,22375198,52103194) Bureau of International Cooperation Chinese Academy of Sciences (121522KYSB20200029) Jilin Province Science and Technology DevelopmentPlan (YDZJ202101ZYTS131,20220402037GH,20210508049RQ) Jilin Provincial International Cooperation Key Laboratory of Biomedical Polymers (20210504001GH) Changchun Science and Technology Development Plan (21ZY09,21ZGY30) the China Postdoctoral Science Foundation (E21S2101) the Youth Talents Promotion Project of Jilin Province (QT202103) the Youth Innovation Promotion Association of Chinese Academy of Sciences (2020232) 

主　　题：oncolytic virus STING pathway gene delivery nanoparticles bioactive materials 

摘      要：Oncolytic viruses have emerged as new powerful therapeutic agents for cancer therapy by specifically lysing cancer cells while activating innate immune responses at the same ***,due to the thorny issues of safety concerns and host immune reaction,the clinical application of oncolytic viruses is still ***,we report a rationally designed oncolytic virus-like nanoparticles(OV-NPs)composed of stimulator of interferon genes(STING)-stimulating polymer loaded with therapeutic genes for cancer *** injection into tumor,the OV-NPs carrying OX40L plasmid could reprogram tumor cells to express OX40L immune checkpoint molecules and activate the STING pathway for cooperatively enhancing antitumor immunity,with a tumor suppression rate of 92.3%in B16F10 tumor model and 78.7%in MC38 tumor model without causing any *** OV-NPs could be further applied in carrying other plasmids(IL-12)and utilization in gene combination *** study should inspire designing synthetic OV-NPs as alternative strategies for extending oncolytic virus application in cancer immunotherapy.