检索结果-南通市图书馆

维普期刊数据库博看期刊

Reconfiguration and self-healing integrated Janus electrospinning nanofiber membranes for durable seawater desalination

在线全文

学校读者我要写书评

暂无评论

Nano Research 2023年第1期16卷 489-495页

作者： Huijie Liu Jiatai Gu Ye Liu Lei Yang Liming Wang Jianyong Yu xiaohong qin Key Laboratory of Textile Science&Technology of Ministry of Education College of TextilesDonghua UniversityShanghai 201620China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials International Joint Laboratory for Advanced Fiber and Lowdimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Innovation Center for Textile Science and Technology Donghua UniversityShanghai 201620China

Janus electrospinning nanofiber membranes have attracted extensive attention in the fields such as solar-driven interfacial desalination,liquid filtration,and waterproof and breathable ***,the Janus structures suffer from weak interfacial bonding and vulnerability to damage,making the durability and sustainability are highly sought after in real-word ***,we fabricate the simply reconfigurable and entirely self-healing Janus evaporator by electrospinning polypropylene glycol based polyurethane(PPG@PU)and polydimethylsiloxane based polyurethane-CNTs(PDMS@PU-CNTs)with different wettability,which are both designed based on dynamic Diels–Alder(DA)*** interface of the Janus membrane is stitched by the covalent bonds to directly improve the interface adhesion to 22 N·m−1,constructing an integrated evaporator,and thereby achieving a stable desalination rate of 1.34 kg·m−2·h−1 under one *** dissociation of DA networks allows the evaporators for self-healing and reconfiguration abilities,after which the photothermal performance is *** is the first work for the crosslinked self-healing polymer to be directly electrospun,achieving the improved interfacial bond and reconfiguration of entire evaporators,which presented promising new design principles and materials for interfacial solar seawater desalination.

关键词： Janus nanofiber membrane electrospinning interfacial bonding solar steam generation seawater desalination

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

4种夏栎对低温胁迫的生理响应及抗寒性评价

河北大学学报（自然科学版） 2024年第4期44卷 406-413页

作者：姜恒张志刚杨建军李斌王兴胜张晓红新疆大学生态与环境学院绿洲生态教育部重点实验室新疆乌鲁木齐830017 自然资源部荒漠-绿洲生态监测与修复工程技术创新中心新疆乌鲁木齐830002 新疆林业科学院造林治沙研究所新疆林木资源与利用国家林草局重点实验室新疆乌鲁木齐830000 伊犁州林木良种繁育试验中心新疆察布查尔835311

为探究低温胁迫下夏栎(quercus robur)生理指标的响应及抗寒性,以普通夏栎、速生夏栎、裂叶夏栎和垂枝夏栎为实验材料,测定在不同温度下细胞膜通透性、超氧化物歧化酶(SOD)、过氧化物酶(POD)、可溶性蛋白等指标,并利用拟合Logistic方程... 详细信息

为探究低温胁迫下夏栎(quercus robur)生理指标的响应及抗寒性,以普通夏栎、速生夏栎、裂叶夏栎和垂枝夏栎为实验材料,测定在不同温度下细胞膜通透性、超氧化物歧化酶(SOD)、过氧化物酶(POD)、可溶性蛋白等指标,并利用拟合Logistic方程计算半致死温度,结合隶属函数法对4种夏栎综合评价.结果表明:4种夏栎细胞膜通透性均随着温度降低而增加,SOD和POD活性以及可溶性蛋白、脯氨酸和丙二醛(MDA)含量均逐渐下降;4种夏栎半致死温度为-41.9~-38.2℃,其中普通夏栎半致死温度最低,速生夏栎半致死温度最高;4种夏栎抗寒性强弱为普通夏栎>垂枝夏栎>裂叶夏栎>速生夏栎.综上可知,普通夏栎抗寒性最强,在不同地区推广和繁育具有显著优势.

关键词：夏栎抗寒性隶属函数法生理指标半致死温度

Hypoxia induced apoptosis of rat gastric mucosal cells by activating autophagy through HIF-1α/TERT/mTORC1 pathway

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2022年第7期46卷 1651-1659页

作者： YAPING WANG xiaohong XUE ZHEN ZHAO XIAOLIN LI ZHIYONG ZHU Department of Digestive Medicine Wuxi Huishan District People’s HospitalWuxiChina Department of Digestive Medicine Qinghai Provincial People’s HospitalXiningChina

The pathogenesis of high altitude-related gastric mucosal injury remains poorly understood,this study aimed to investigate the role of autophagy in hypoxia-induced apoptosis of rat gastric mucosal *** were randomized into four groups which were maintained at an altitude of 400 m(P)or received no treatment(H),autophagy inducer rapamycin(H+AI)or autophagy inhibitor 3-MA(H+AB)at an altitude of 4,300 m for 1,7,14 and 21 days,respectively,and the morphology,ultrastructure,autophagy,and apoptosis of gastric mucosal tissues were *** mucosal epithelial cells CC-R039 were cultured under conditions of normoxia,2%O2(hypoxia),or 2%O2+anti-mTORC1 for 0,24,48,and 72 h,respectively,and the autophagy and apoptosis were ***-R039 cells were transfected with siHIF-1α,siTERT,or siRNA and the autophagy was *** results showed that the exposure to hypoxia increased the autophagy and apoptosis of gastric mucosal cells in rats,and apoptosis was aggravated by rapamycin treatment but alleviated by 3-MA *** duration of hypoxia from 0 to 72 h could increase the autophagy and apoptosis but decrease the proliferation of gastric mucosal *** of mTORC1 with rapamycin led to further increase in apoptosis and even substantial cell death,and inhibition of HIF-1αand TERT increased mTORC1 expression and reduced ***,the inhibition of HIF-1αreduced TERT *** conclusion,hypoxia could induce apoptosis of rat gastric mucosal cells by activating autophagy through HIF-1α/TERT/mTORC1 pathway.

关键词： Hypoxia Autophagy Apoptosis HIF-1α TERT mTORC1

Electromechanical coupling driving control for single-shaft parallel hybrid powertrain

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Technological Sciences) 2014年第3期57卷 541-549页

作者： YANG Chao JIAO xiaohong LI Liang ZHANG YaHui ZHANG LiPeng SONG Jian Institute of Electric Engineering Yanshan University State Key Laboratory of Automotive Safe and Energy Tsinghua University

The single-shaft parallel hybrid powertrain with the automatic mechanical transmission(AMT)is an efficient hybrid driving system in the hybrid electric bus(HEB),while the electromechanical coupling driving control becomes a complicated question to find a transient optimal control method to distribute the power between the engine and the electric machine(EM).This paper proposes an innovative control method to deal with the complicated transient coupling driving process of the electromechanical coupling driving system,considering the accelerating condition and the cruising condition mostly in the city driving cycle of *** EM might be operated at driving mode or generating mode to assist the diesel engine to work in its high-efficiency ***,the adaptive torque tracking controller has been brought forward to ensure that the EM implements the demand torque as well as compensate the torque fluctuation of diesel *** d?q axis mathematical model and back stepping method are employed to deduce the adaptive controller and its adaptive *** results demonstrate that the proposed control scheme can make the output torque of two power sources respond rapidly to the demand torque from the powertrain in the given driving *** proposed method could be adopted in the real control of HEB to improve the efficiency of the hybrid driving system.

关键词： single-shaft parallel hybrid powertrain coupling driving control adaptive control torque tracking

变量核Marcinkiewicz积分交换子在变指标λ-中心Morrey空间上的有界性

在线全文

学校读者我要写书评

暂无评论

青海大学学报 2024年第1期42卷 95-99页

作者：邵旭馗崔建斌岳晓红陇东学院数学与信息工程学院陇东学院应用数学研究所甘肃庆阳745000

应用核函数Ω(x,z)的性质,证明了由变量核Marcinkiewicz积分算子μ_(Ω,m)^(θ)与Lipschitz函数b生成的交换子μ_(Ω,m,b)^(θ)是变指标λ-中心Morrey空间M^(q(·),λ)(R^(n))上的有界算子,扩宽了以往的研究结果.

关键词： Marcinkiewicz积分算子变指标λ-中心Morrey空间交换子变量核

川芎嗪对脊髓损伤大鼠Nrf2/HO-1通路及氧化应激的调控作用

在线全文

学校读者我要写书评

暂无评论

中华中医药杂志 2024年第5期39卷 2575-2581页

作者：陶经纬周婧雅刘奕扬赵毅任敬佩胡传宇徐林穆晓红范筱北京中医药大学东直门医院北京100700 北京中医药大学北京100029 青岛市市立医院青岛266011

目的:研究川芎嗪通过核转录因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)通路抑制脊髓损伤大鼠氧化应激损伤的作用机制。方法:雌性SD大鼠60只,随机分为假手术组,模型组,川芎嗪高、中、低剂量组。假手术组大鼠切除椎板后,不进行脊髓打击,... 详细信息

目的:研究川芎嗪通过核转录因子E2相关因子2(Nrf2)/血红素加氧酶1(HO-1)通路抑制脊髓损伤大鼠氧化应激损伤的作用机制。方法:雌性SD大鼠60只,随机分为假手术组,模型组,川芎嗪高、中、低剂量组。假手术组大鼠切除椎板后,不进行脊髓打击,每日予腹腔注射等量0.9%氯化钠溶液;模型组大鼠切除椎板后,打击脊髓制备脊髓损伤模型,术后每日给予腹腔注射0.9%氯化钠溶液;川芎嗪组大鼠切除椎板后,打击脊髓制备脊髓损伤模型,术后每日给予川芎嗪腹腔注射。评估大鼠造模前、造模后1、3、7、14、21、28天BBB后肢运动功能评分,尼氏染色观察脊髓神经元形态,ELISA检测超氧化物歧化酶(SOD)、丙二醛(MDA)表达水平,Western Blot检测Nrf2、HO-1表达水平,q RT-PCR检测Nrf2、HO-1 mRNA表达水平,免疫组化法检测Keap1、P62表达水平,荧光染色检测活性氧(ROS)的表达量。结果:造模后14、21、28天各剂量川芎嗪组大鼠BBB评分高于模型组(P1);SOD表达量高于模型组(P1)。Western Blot结果显示:川芎嗪组大鼠脊髓组织Nrf2、HO-1蛋白表达量高于模型组(P1,PqRT-PCR结果显示:川芎嗪组大鼠脊髓组织Nrf2、HO-1 mRNA表达量高于模型组和假手术组(P1,P1表达显著低于模型组和假手术组(P1),高于假手术组(P1)。结论:川芎嗪能够通过NRF2/HO-1信号通路调控抗氧化作用发挥神经保护作用。

关键词：脊髓损伤核转录因子E2相关因子2/血红素加氧酶1通路氧化应激川芎嗪大鼠

Functional genomic studies on an immune-and antiviral-related gene of MyD88 in orange-spotted grouper,Epinephelus coioides

在线全文

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2012年第25期57卷 3277-3287页

作者： YAN Yang CUI HuaChun WEI JingGuang HUANG YouHua HUANG xiaohong qIN qiWei Key Laboratory of Marine Bio-resources Sustainable Utilization South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China

Myeloid differentiation factor 88(MyD88) is a universal adaptor protein involved in Toll-like receptors and in interleukin-1 receptor-induced nuclear factor-kappaB(NF-κB) *** this study,a new MyD88 gene(designated as Og-MyD88) was cloned from orange-spotted grouper,Epinephelus coioides,based on the expressed sequence tag(EST) obtained following Roche 454 GS-FLX *** full-length Og-MyD88 cDNA is composed of 1682 bp and encodes a deduced polypeptide of 289 amino acids with 86% homology to MyD88 of Siniperca *** deduced amino acid sequence of Og-MyD88 contains a typical death domain at the amino terminus and a conserved Toll/IL-1R(TIR) domain at the carboxyl terminus,as well as three highly conserved motifs(Box1,Box2 and Box3) within the C-terminal TIR *** healthy fish,Og-MyD88 was found to be strongly expressed in immune-related tissues,including the spleen,head kidney,kidney,liver,skin and intestine,with lower expression in heart,stomach,brain and *** of Og-MyD88 were found to be markedly up-regulated in fish spleen after challenge with Singapore grouper iridovirus(SGIV),a highly lethal viral pathogen to grouper ***,the full length Og-MyD88 and its N-terminal death domain were capable of inducing NF-κB activity in HEK-293 *** Og-MyD88 showed the ability to inhibit replication of SGIV in grouper spleen(GS) *** results suggest that Og-MyD88 is involved in the grouper immune response to invasion of viral pathogens and may share similar functions to those observed in higher vertebrates.

关键词：抗病毒相关基因功能基因组学石斑鱼免疫相关 Toll样受体核因子-κB 氨基酸序列死亡结构域

动静脉移植物内瘘狭窄的发生情况及干预效果分析

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华医学杂志 2024年第32期104卷 3025-3031页

作者：王宇飞刘文静张倍豪王欣芳王瑞敏薛小玲岳晓红王沛梁献慧郑州大学第一附属医院血液净化中心郑州郑州大学第一附属医院肾内科郑州

目的探讨血液透析患者动静脉移植物内瘘(AVG)狭窄的发生情况、干预方式及效果。方法回顾性分析2018年1月至2022年12月在郑州大学第一附属医院血液净化中心构建AVG患者的通路资料。分析AVG的通畅情况、通路事件干预情况、AVG狭窄的发生... 详细信息

目的探讨血液透析患者动静脉移植物内瘘(AVG)狭窄的发生情况、干预方式及效果。方法回顾性分析2018年1月至2022年12月在郑州大学第一附属医院血液净化中心构建AVG患者的通路资料。分析AVG的通畅情况、通路事件干预情况、AVG狭窄的发生情况及不同干预方式的效果。结果共纳入475例患者, 男193例(40.6%), 女282例(59.4%), 年龄(55.5±11.8)岁。随访时间[M(q1, q3)]19(12, 30)个月, AVG的初级、初级辅助、次级通畅时间分别为14(5, 27)、27(13, 55)及59(33, 65)个月。共发生799 例次进行干预的通路事件, 标化干预率为0.90次/患者年, 其中431例次(53.9%, 431/799)为狭窄。狭窄事件集中发生在207个AVG中。在临床资料完善的422例次AVG狭窄事件中, 57.8%(244/422)为多部位狭窄, 42.2 %(178/422)为单一部位狭窄;狭窄前三位的好发部位分别为静脉吻合口附近(47.6%, 340/715)、静脉流出道(22.7%, 162/715)、穿刺区域(20.0%, 143/715)。在干预后随访资料完整的414例次狭窄干预中, 376例次(90.8%, 376/414)采用经皮腔内球囊扩张术进行干预, 35例次(8.5%, 35/414)植入覆膜支架, 3 例次(0.7%, 3/414)采用外科干预, 临床成功率98.1%(406/414)。腔内介入干预后的初级通畅时间为6(4, 12)个月。支架植入患者术后AVG的初级通畅时间优于支架植入术前一次单纯球囊扩张干预后的初级通畅时间[6(3, 7)个月比3(1, 4)个月, P=0.020]。结论狭窄是AVG最常见的并发症, 好发部位依次为静脉吻合口附近、静脉流出道和穿刺区域。AVG狭窄干预有较高的临床成功率, 但干预后初级通畅时间较短。支架植入术可改善球囊扩张效果较差的AVG狭窄的通畅时间。

关键词：血液透析动静脉移植物内瘘狭窄通畅率

基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘的分子机制

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中药新药与临床药理 2024年第2期35卷 247-256页

作者：连乐燊孟星汝黄秀芳周谨希谢燕小陶海澜蒋紫云刘小虹广州中医药大学东莞医院广东东莞523000 广州中医药大学第一临床医学院广东广州510405 广州中医药大学第一附属医院广东广州510405 广州中医药大学岭南医学研究中心广东广州510405 广州中医药大学第三临床医学院广东广州510370

目的基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘(NA)的分子机制。方法(1)利用中药系统药理学数据库和分析平台(TCMSP)、文献检索及Swiss ADME、Swiss Target Prediction数据库检索、筛选射麻止喘液的活性成分及其作... 详细信息

目的基于网络药理学及体内实验探讨射麻止喘液治疗中性粒细胞型哮喘(NA)的分子机制。方法(1)利用中药系统药理学数据库和分析平台(TCMSP)、文献检索及Swiss ADME、Swiss Target Prediction数据库检索、筛选射麻止喘液的活性成分及其作用靶点。利用OMIM、Gene Cards、Dis Ge NET及Drug Bank数据库检索、筛选NA疾病相关靶点。通过微生信平台对射麻止喘液活性成分作用靶点与NA疾病相关靶点取交集,得到射麻止喘液治疗NA的潜在作用靶点(共有靶点)。采用Cytoscape 3.8软件构建“中药-活性成分-潜在作用靶点”网络。通过STRING数据库建立潜在作用靶点蛋白互作(PPI)网络,使用内置Mcode插件分析获得核心靶点。使用Metascape平台对潜在作用靶点进行基因本体(GO)、京都基因和基因组百科全书(KEGG)通路富集分析。(2)将BALB/C小鼠适应性喂养1周后,随机分为空白组、NA模型组、射麻止喘液低剂量组(2.5 g·kg^(-1))、射麻止喘液高剂量组(10 g·kg^(-1))、地塞米松对照组(1 mg·kg^(-1));通过腹腔注射致敏剂[鸡卵清白蛋白(OVA)+弗氏完全佐剂(CFA)]并通过雾化吸入激发的方法复制NA小鼠模型,第0、7、14天分别腹腔注射OVA+CFA(20μg OVA+75μg CFA,0.3 m L)致敏,第21~30天采用5%OVA混悬液雾化激发(每次8 m L,每次雾化时间40 min,每天1次);雾化激发前1 h各组灌胃给药,地塞米松对照组腹腔注射给药,每天1次。采用HE染色法观察小鼠肺组织病理变化;ELISA法检测肺泡灌洗液中IL-8含量;RT-q PCR法检测肺组织中NLRP3、CXCR2 m RNA表达水平;免疫组化法检测肺组织中p-m TOR蛋白表达水平。结果(1)共筛选得到射麻止喘液活性成分作用靶点826个,NA疾病相关靶点154个,取交集后得到射麻止喘液治疗NA的51个潜在作用靶点(共有靶点)。通过“中药-活性成分-潜在作用靶点”网络分析得到槲皮素、木犀草素、山柰酚、豆甾醇、柚皮素等关键活性成分。通过对潜在作用靶点的PPI网络分析得到29个核心靶点,包括AKT1、IL6、TNF、EGFR、NLRP3、RELA、MIF、CXCR2、VEGFA等。GO功能富集分析得到882个生物学过程条目、33个细胞组分条目、61个分子功能条目;KEGG通路富集分析得到142条信号通路,主要涉及TNF信号通路、甲型流感信号通路、Toll样受体通路、MAPK信号通路、m TOR信号通路等。(2)动物实验结果:与空白组比较,NA模型组小鼠的气道黏膜损伤明显,结构紊乱,有大量炎性细胞浸润,黏膜充血、水肿,肺泡壁明显增厚,肺泡腔缩小;肺泡灌洗液中的炎症因子IL-8水平明显升高(P1),p-m TOR蛋白表达水平明显升高。与NA模型组比较,射麻止喘液低、高剂量组小鼠肺组织支气管上皮细胞结构排列可见少许紊乱,气管及血管周围有少量的炎性细胞浸润,支气管黏膜充血水肿明显减轻;小鼠肺组织CXCR2 m RNA表达显著下调(P1),p-m TOR蛋白表达水平明显降低。射麻止喘液高剂量组小鼠肺泡灌洗液中的IL-8水平明显降低(P<0.05);射麻止喘液低剂量组小鼠肺组织NLRP3m RNA表达明显下调(P<0.05)。结论射麻止喘液对NA的治疗作用可能是通过槲皮素、木犀草素、山柰酚等关键活性成分,作用于NLRP3、CXCR2等核心靶点,调控TNF信号通路、MAPK信号通路、Toll样信号通路、m TOR等关键信号通路来实现的。

关键词：射麻止喘液中性粒细胞型哮喘网络药理学 NLRP3 CXCR2 mTOR信号通路小鼠