检索结果-南通市图书馆

Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots:An in Vitro and in Vivo Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第11期42卷 235-243页

作者： Huaiyu Wu Jinwook Kim Bohua Zhang Gabe Owens Greyson Stocker Mengyue Chen Benjamin C.Kreager Ashley Cornett Kathlyne Bautista Tarana Kaovasia paul a.dayton Zhen Xu Xiaoning Jiang Department of Mechanical and Aerospace Engineering North Carolina State UniversityRaleighNC 27695USA Joint Department of Biomedical Engineering The University of North Carolina at Chapel HillChapel HillNC 27599USA Department of Biomedical Engineering University of MichiganAnn ArborMI 48109USA

Thromboembolism in blood vessels poses a serious risk of stroke,heart attack,and even sudden death if not properly *** combined with ultrasound contrast agents has emerged as a promising approach for the effective treatment of *** reports have highlighted the potential of intravascular sonothrombolysis as a safe and effective treatment modality for deep vein thrombosis(DVT).However,its efficiency has not been validated through in vivo testing of retracted *** study aimed to develop a miniaturized multidirectional transducer featuring two 4-layer lead zir-conate titanate(PZT-5A)stacks with an aperture size of 1.4 mm1.4 mm,enabling both forward-and side-looking *** into a custom two-lumen 10-French(Fr)catheter,the capability of this device for intravascular sonothrombolysis was validated both in vitro and in *** low-dose tissue plasminogen activators and nanodroplets,the rotational multidirectional transducer reduced the retracted clot mass(800 mg)by an average of 52%within 30 min during in vitro *** lysis rate was significantly higher by 37%than that in a forward-viewing transducer without *** improvement was particularly noteworthy in the treatment of retracted ***,a long-retracted clot(>10 cm)was successfully treated within 40 min in vivo by creating a flow channel with a diameter>4 mm in a porcine DVT *** conclusion,these findings strongly suggest the potential of this technique for clinical applications in sonothrombolysis,offering a feasible solution for effectively treating thromboembolism,particularly in challenging cases involving retracted clots.

关键词： Intravascular ultrasound catheter Sonothrombolysis in vivo Retracted clots thrombolysis

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Research 2023年第1期2023卷 1-13页

作者： Bohua Zhang Huaiyu Wu Howuk Kim Phoebe J.Welch Ashley Cornett Greyson Stocker Raul G.Nogueira Jinwook Kim Gabe Owens paul a.dayton Zhen Xu Chengzhi Shi Xiaoning Jiang Department of Mechanical&Aerospace Engineering North Carolina State UniversityRaleighNCUSA Department of Mechanical Engineering Inha University IncheonRepublic of Korea George W.Woodruff School of Mechanical Enginering Grgia lnstitute of TechnlogyAtlantaGAUSA Department of Biomedical Engineering University of Michigan Ann ArborMIUSA Department of Neurology Universityof Pittsburgh Medical CenterPttsburghPA USA Department of Biomedical Engineering University of North CarolinaChapel HillNCUSA Parker H.Petit Institute for Bioengineering and Bioscience Georgia Institute of TechnologyAtlantaGAUSA

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis(CVST).This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20%to 40%of the cases,and the incidence of CvST has increased since the outbreak of the coronavirus disease 2019 *** with conventional anticoagulant or thrombolytic drugs,sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic ***,previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes(e.g.,recanalization within 30 min)in treating large,completely occluded veins or ***,we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wavematter interaction-induced shear stress to enhance the lytic rate *** in vitro experiment showed that the lytic rate was increased by at least 64.3%compared with the nonvortex endovascular ultrasound treatment.A 3.1-g,7.5-cm-long,completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot ***,we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine *** vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.

关键词： thrombolysis drugs vortex

用于溶栓的旋转式血管内多方向超声导管——体外和体内研究（英文）

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering 2024年第11期 235-243页

作者： Huaiyu Wu Jinwook Kim Bohua Zhang Gabe Owens Greyson Stocker Mengyue Chen Benjamin C.Kreager Ashley Cornett Kathlyne Bautista Tarana Kaovasia paul a.dayton Zhen Xu Xiaoning Jiang Department of Mechanical and Aerospace Engineering North Carolina State University Joint Department of Biomedical Engineering The University of North Carolina at Chapel Hill Department of Biomedical Engineering University of Michigan

Thromboembolism in blood vessels poses a serious risk of stroke, heart attack, and even sudden death if not properly managed. Sonothrombolysis combined with ultrasound contrast agents has emerged as a promising approach for the effective treatment of thromboembolism. Recent reports have highlighted the potential of intravascular sonothrombolysis as a safe and effective treatment modality for deep vein thrombosis(DVT). However, its efficiency has not been validated through in vivo testing of retracted *** study aimed to develop a miniaturized multidirectional transducer featuring two 4-layer lead zirconate titanate(PZT-5A) stacks with an aperture size of 1.4 mm × 1.4 mm, enabling both forwardand side-looking treatment. Integrated into a custom two-lumen 10-French(Fr) catheter, the capability of this device for intravascular sonothrombolysis was validated both in vitro and in vivo. With low-dose tissue plasminogen activators and nanodroplets, the rotational multidirectional transducer reduced the retracted clot mass(800 mg) by an average of 52% within 30 min during in vitro testing. The lysis rate was significantly higher by 37% than that in a forward-viewing transducer without rotation. This improvement was particularly noteworthy in the treatment of retracted clots. Notably, a longretracted clot(> 10 cm) was successfully treated within 40 min in vivo by creating a flow channel with a diameter > 4 mm in a porcine DVT model. In conclusion, these findings strongly suggest the potential of this technique for clinical applications in sonothrombolysis, offering a feasible solution for effectively treating thromboembolism, particularly in challenging cases involving retracted clots.

关键词：

Carbon-based supercapacitors for efficient energy storage

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2017年第3期4卷 453-489页

作者： Xuli Chen Rajib paul Liming Dai Center of Advanced Science and Engineering for Carbon (Case 4 Carbon) Department of Macromolecular Science and Engineering Case School of Engineering Case Western Reserve University

The advancement of modern electronic devices depends strongly on the highly efficient energy sources possessing high energy density and power density. In this regard, supercapacitors show great promise. Due to the unique hierarchical structure, excellent electrical and mechanical properties, and high specific surface area, carbon nanomaterials(particularly, carbon nanotubes, graphene, mesoporous carbon and their hybrids) have been widely investigated as efficient electrode materials in supercapacitors. This review article summarizes progress in high-performance supercapacitors based on carbon nanomaterials with an emphasis on the design and fabrication of electrode structures and elucidation of charge-storage mechanisms. Recent developments on carbon-based flexible and stretchable supercapacitors for various potential applications,including integrated energy sources, self-powered sensors and wearable electronics, are also discussed.

关键词： electric double-layer supercapacitors pseudocapacitors hybrid supercapacitors carbon nanotube(CNT) graphene flexible and wearable electronics

Pulse-burst laser-based 10kHz Thomson scattering measurements

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Plasma Science and Technology 2019年第10期21卷 83-90页

作者： Zichen HE Cary SMITH Zhili ZHANG Theodore M BIEWER Naibo JIANG paul S HSU Sukesh ROY Mechanical Aerospace and Biomedical EngineeringUniversity of TennesseeKnoxville TN 37996 United States of America Fusion Energy Division Oak Ridge National LaboratoryOak Ridge TN 37931United States of America Spectral Energies LLC Dayton OH 45431United States of America

Thomson scattering (TS), as a popular and reliable diagnostic technique, has successfully measured electron temperatures and electron number densities of plasmas for many years. However, conventional TS techniques using Nd:YAG lasers operate only at tens of hertz. Here, we present the development of a high-repetition-rate TS instrument based on a high-speed, pulse-burst laser system to greatly increase the temporal resolution of measurements. Successful instrument prototype testing was carried out by collecting TS light from laboratory helium and argon plasmas at 10 kHz. Calibration of the instrument detection sensitivity using nitrogen/ oxygen rotational Raman scattering signal is also presented. Quantitative electron number densities and electron temperatures of the plasma were acquired at 10 kHz, for stable plasma discharges as, respectively,~0.9 eV and ~5.37×10^21 m^-3 for the argon plasma, and ~1 eV and ~6.5×10^21 m^-3 for the helium plasma.

关键词： Thomson scattering high-speed pulse-burst laser

Charge transfer of carbon nanomaterials for efficient metal‐free electrocatalysis

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interdisciplinary Materials 2022年第1期1卷 28-50页

作者： Rajib paul Qingfeng Zhai Ajit K.Roy Liming Dai Department of Macromolecular Science and Engineering Case School of EngineeringCase Western Reserve UniversityClevelandOhioUSA Australian Carbon Materials Centre(A-CMC) School of Chemical EngineeringUniversity of New South WalesSydneyNew South WalesAustralia Materials and Manufacturing Directorate Air Force Research LaboratoryDaytonOhioUSA

Recently,carbon-based metal-free electrocatalysts(C‐MFECs)have drawn considerable research attention because of their attractive physicochemical characteristics,cost-effectiveness,and ability to convert and store energy *** intramolecular charge transfer among different parts of the carbon electrocatalyst and/or intermolecular charge transfer between elec-trocatalyst and electrolyte dictate the ultimate energy conversion *** results and theoretical analyses have demonstrated that rational design of metal-free carbon nanomaterials,coupled with proper in-tramolecular charge transfer through heteroatom doping,incorporation of Stone-Wales defects,and/or intermolecular charge transfer through adsorp-tion of appropriate molecules/moieties,can promote efficient *** this article,we will first provide the related theoretical principles and then present an overview on the rational design and development of C-MFECs for efficient charge transfer,followed by elucidating charge-transfer processes for different electrocatalytic reactions related to renewable energy conversion and environmental remediation ***,the current challenges and future perspectives in this exciting field will be discussed.

关键词： carbon catalyst charge transfer defect doping

Near-UV electroluminescence in unipolar-doped, bipolar-tunneling GaN/AlN heterostructures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2017年第1期6卷 168-174页

作者： Tyler A Growden Weidong Zhang Elliott R Brown David F Storm David J Meyer paul R Berger Department of Electrical and Computer Engineering The Ohio State UniversityColumbusOhio 43210USA Departments of Physics and Electrical Engineering Wright State UniversityDaytonOhio 45435USA US Naval Research Laboratory WashingtonDC 20375USA

Cross-gap light emission is reported in n-type unipolar GaN/AlN double-barrier heterostructure diodes at room *** different designs were grown on semi-insulating bulk GaN substrates using molecular beam epitaxy(MBE).All samples displayed a single electroluminescent spectral peak at 360 nm with full-width at half-maximum(FWHM)values no greater than 16 nm and an external quantum efficiency(EQE)of≈0.0074%at 18.8 *** contrast to traditional GaN light emitters,p-type doping and p-contacts are completely avoided,and instead,holes are created in the GaN on the emitter side of the tunneling structure by direct interband(that is,Zener)tunneling from the valence band to the conduction band on the collector *** Zener tunneling is enhanced by the high electric fields(~5×106 V cm^(−1))created by the notably large polarization-induced sheet charge at the interfaces between the AlN and GaN.

关键词： AlN GaN heterostructure Near-UV light emission unipolar Zener tunneling

Braid Group Representations from Twisted Tensor Products of Algebras

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peking Mathematical Journal 2020年第2期3卷 103-130页

作者： paul Gustafson Andrew Kimball Eric C.Rowell Qing Zhang Department of Electrical Engineering Wright State UniversityDaytonOH 45435USA Department of Mathematics Texas A&M UniversityCollege StationTX 77843-3368USA

We unify and generalize several approaches to constructing braid group representa-tions from finite groups,using iterated twisted tensor *** provide some general characterizations and classification of these representations,focusing on the size of their images,which are typically finite *** well-studied Gaussian representations associated with metaplectic modular categories can be understood in this framework,and we give some new examples to illustrate their *** results suggest a relationship between the braiding on the G-gaugings of a pointed modular category C(A,Q)and that of C(A,Q)itself.

关键词： Braid group Yang-Baxter operator Twisted tensor product Group algebra Unitary representations Property F

The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2/ANKK (Taq1A)), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Immunology 2024年第3期14卷 60-86页

作者： Kenneth Blum Igor Elman David Han Colin Hanna David Baron Ashim Gupta Shan Kazmi Jag Khalsa Debasis Bagchi Thomas McLaughlin Rajendra D. Badgaiyan Edward J. Modestino Drew Edwards Catherine A. Dennen Eric R. Braverman Abdalla Bowirrat Keerthy Sunder Kevin Murphy Nicole Jafari Foojan Zeine paul R. Carney Mark S. Gold Kai-Uwe Lewandowski Alireza Sharafshah Aryeh R. Pollack Panayotis K. Thanos Division of Addiction Research & Education Center for Sports and Mental Health Western University of Health Sciences Pomona CA USA Department of Psychiatry Boonshoft School of Medicine Wright State University and Dayton VA Medical Centre Dayton OH USA Division of Nutrigenomics Victory Nutrition International Lederoch PA USA Institute of Psychology ELTE Etvs Lornd University Budapest Hungary Department of Psychiatry School of Medicine University of Vermont Burlington VT USA The Kenneth Blum Behavioral & Neurogenetic Institute LLC. Austin TX USA Department of Molecular Biology Adelson School of Medicine Ariel University Ariel Israel Division of Neuromodulation Research Karma Doctors & Karma TMS Palm Springs CA USA Division of Personalized Interventions Peak Logic Del Mar CA USA Division of Personalized Medicine Cross-Cultural Research & Educational Institute San Clemente CA USA Awareness Integration Institute San Clemente CA USA Division of Personalized Pain Therapy Center for Advanced Spine Care of Southern Arizona Tucson AZ USA Department of Psychiatry Harvard School of Medicine Cambridge MA USA Department of Management Science and Statistics University of Texas San Antonio TX USA Behavioral Neuropharmacology and Neuroimaging Laboratory Clinical Research Institute on Addictions Department of Pharmacology and Toxicology Jacobs School of Medicine and Biomedical Sciences University at Buffalo Buffalo NY USA Future Biologics Lawrenceville GA USA Department of Microbiology Immunology & Tropic Diseases School of Medicine Georgetown University Washington DC USA Department of Pharmaceutical Sciences College of Pharmacy Texas Southern University Houston TX USA Department of Psychiatry School of Medicine Case Western University Cleveland OH USA Brain and Behavior Laboratory Curry College Milton MA USA The Neurogenesis Project Jacksonville FL USA Department of Family Medicine Jefferson Health Northeast Philadelphia PA USA Departmen

Pediatric autoimmune neuropsychiatric disorders associated with or without streptococcal and other bacterial infections (PANDAS/CANS) are emerging as a featured pediatric disorder. Although there is some controversy regarding treatment approaches, especially related to the behavioral sequelae, we have hypothesized in other published work that it is characterized by the rapid onset of Reward Deficiency Syndrome (RDS) in children. We propose utilizing a multi-systems biological approach involving the coupling of genetic addiction risk testing and pro-dopamine regulation (KB220/POLYGEN®) to help induce “dopamine homeostasis” in patients with PANDAS, especially those with known DNA-induced hypodopaminergia. This case study examines a 12-year-old Caucasian male with no prior psychiatric issues who presented with a sudden onset of severe anxiety, depression, emotional liability, and suicidal ideation. The patient underwent genotyping and the genetic addiction risk score (GARS) testing, which revealed risk polymorphisms in the dopamine D2 (-DRD2/ANKK (Taq1A), OPRM1 (A/G), DRD3 (C/T), and MAOA (4R) genes. These polymorphisms have been linked to hypodopaminergia. The patient was subsequently placed on research ID-KB220ZPBMPOLY (POLYGEN®), and albeit the possibility of bias, based upon self and parental assessment, a marked rapid improvement in psychiatric symptoms was observed. In the second phase of treatment (102 days utilizing KB220), the patient received standard antibody testing, which was positive for Lyme. Antibacterial therapy started immediately, and KB220z was discontinued to provide a wash-out period. A monotonic trend analysis was performed on each outcome measure, and a consistently decreasing trend was observed utilizing antibacterial therapy. Our recommendation, albeit only one case, is to utilize and further research a combined therapeutic approach, involving precision-guided DNA testing and pro-dopamine regulation along with antibacterial therapy, as well as

关键词： PANDAS CANS Genetic Addiction Risk Testing (GARS) Pro-Dopamine Regulation Hypodopaminergia Polymorphisms Antibacterial Therapy Infections