Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

作     者：Leela Goel Huaiyu Wu Bohua Zhang Jinwook Kim Paul A.Dayton Zhen Xu Xiaoning Jiang 

作者机构：Department of Mechanical&Aerospace EngineeringNorth Carolina State UniversityRaleighNC 27695USA The Joint Department of Biomedical EngineeringThe University of North Carolina at Chapel Hill and North Carolina State UniversityChapel HillNC 27599USA Department of Biomedical EngineeringUniversity of MichiganAnn ArborMI 48109USA 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2021年第7卷第1期

页      面：77-83页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：supported by National Institutes of Health grant R01HL141967 

主　　题：thrombolysis directed boiling 

摘      要：One major challenge in current microbubble(MB)and tissue plasminogen activator(tPA)-mediated sonothrombolysis techniques is effectively treating retracted blood clots,owing to the high density and low porosity of retracted ***(NDs)have the potential to enhance retracted clot lysis owing to their small size and ability to penetrate into retracted clots to enhance drug *** the first time,we demonstrate that a sub-megahertz,forwardviewing intravascular(FVI)transducer can be used for ND-mediated sonothrombolysis,in *** this study,we determined the minimum peak negative pressure to induce cavitation with low-boiling point phase change nanodroplets and clot *** then compared nanodroplet mediated sonothrombolysis to MB and tPA mediate *** clot lysis as a percent mass decrease in retracted clots was 9±8%,9±5%,16±5%,14±9%,17±9%,30±8%,and 40±9%for the control group,tPA alone,tPA+US,MB+US,MB+tPA+US,ND+US,and ND+tPA+US groups,*** retracted blood clots,combined ND-and tPA-mediated sonothrombolysis was able to significantly enhance retracted clot lysis compared with traditional MB and tPA-mediated sonothrombolysis *** nanodroplet with tPA-mediated sonothrombolysis may provide a feasible strategy for safely treating retracted clots.