A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

作     者：Bohua Zhang Huaiyu Wu Howuk Kim Phoebe J.Welch Ashley Cornett Greyson Stocker Raul G.Nogueira Jinwook Kim Gabe Owens Paul A.Dayton Zhen Xu Chengzhi Shi Xiaoning Jiang 

作者机构：Department of Mechanical&Aerospace EngineeringNorth Carolina State UniversityRaleighNCUSA Department of Mechanical EngineeringInha University IncheonRepublic of Korea George W.Woodruff School of Mechanical EngineringGrgia lnstitute of TechnlogyAtlantaGAUSA Department of Biomedical Engineering University of MichiganAnn ArborMIUSA Department of NeurologyUniversityof Pittsburgh Medical CenterPttsburghPA USA Department of Biomedical EngineeringUniversity of North CarolinaChapel HillNCUSA Parker H.Petit Institute for Bioengineering and BioscienceGeorgia Institute of TechnologyAtlantaGAUSA 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2023年第2023卷第1期

页      面：1-13页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：support from the National Institutes of Health(grant numbers R01HL141967,R41HL154735,and R21EB027304) support from the National Science Foundation(grant number CMMI-2142555) 

主　　题：thrombolysis drugs vortex 

摘      要：This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis(CVST).This is a topic of substantial importance since current treatment modalities for CVST still fail in as many as 20%to 40%of the cases,and the incidence of CvST has increased since the outbreak of the coronavirus disease 2019 *** with conventional anticoagulant or thrombolytic drugs,sonothrombolysis has the potential to remarkably shorten the required treatment time owing to the direct clot targeting with acoustic ***,previously reported strategies for sonothrombolysis have not demonstrated clinically meaningful outcomes(e.g.,recanalization within 30 min)in treating large,completely occluded veins or ***,we demonstrated a new vortex ultrasound technique for endovascular sonothrombolysis utilizing wavematter interaction-induced shear stress to enhance the lytic rate *** in vitro experiment showed that the lytic rate was increased by at least 64.3%compared with the nonvortex endovascular ultrasound treatment.A 3.1-g,7.5-cm-long,completely occluded in vitro 3-dimensional model of acute CVST was fully recanalized within 8 min with a record-high lytic rate of 237.5 mg/min for acute bovine clot ***,we confirmed that the vortex ultrasound causes no vessel wall damage over ex vivo canine *** vortex ultrasound thrombolysis technique potentially presents a new life-saving tool for severe CVST cases that cannot be efficaciously treated using existing therapies.