检索结果-南通市图书馆

Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from <i>Canarium odontophyllum</i>Miq.

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

American Journal of Plant Sciences 2014年第19期5卷 2878-2888页

作者： Dayang Fredalina Basri Nur Hafidzah mohd nor School of Diagnostic & Applied Health Sciences Faculty of Health Sciences Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia

Canarium odontophyllum is one of the underutilized fruits among the local community in Sarawak, Malaysia. The leaf extracts from C. odontophyllum (6.25 mg/ml to 50 mg/m) were screened against two Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Extraction of the C. odontophyllum leaves using methanol produced the highest yield (5.46%) followed by water (4.0%) and acetone (2.83%) whereas hexane extracted the lowest yield (0.98%). Out of the four bacterial species tested, only S. aureus was found to be susceptible towards the C. odontophyllum leaves extract. Screening result using agar well diffusion method showed that the antimicrobial activity of the acetone and methanol extracts from C. odontophyllum leaves was concentration-dependent towards the growth inhibition of S. aureus. The MIC values for both MeOH and acetone extracts were 0.391 mg/ml. The MBC value of MeOH extract was twice its MIC value whereas the MBC and MIC values of acetone extract against S. aureus were the same. Phytochemical analysis showed that acetone, MeOH and water extracts contain flavonoid, tannin, terpenoid and phenol. These findings conclude that the leaves of C. odontophyllum may contain therapeutically-useful compounds against S. aureus, which are mostly concentrated in the acetone extract. As such, C. odontophyllum have the potential to be developed as an alternative treatment against Staphylococcus aureus-associated skin and soft tissue infections.

关键词： Leaves Canarium odontophyllum Flavonoid Saponin Antibacterial Agar Well Diffusion Staphyloccocus aureus MIC MBC

Acarine ectoparasites of Panti Forest Reserve in Johore,Malaysia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2011年第1期1卷 1-5页

作者： Mariana A mohd Kulaimi B Halimaton I Suhaili ZA Shahrul-Anuar MS nor Zalipah M Ho TM Acarology Unit Infectious Diseases Research CentreInstitute for Medical Research School of Biological Sciences Universiti Sains Malaysia Department of Biological Sciences Faculty of Science and TechnologyUniversiti Malaysia Terengganu

Objective:To identify the presence of acarine ectoparasites and determine whether there is any potential public health risk in Panti Forest Reserve,Johore,***:Trapping of animals and avifauna was conducted simultaneously along 5 expedition trails using 150 wire traps,10 harp traps and 30 mist nets for 6 consecutive nights.A total of 140 animals consisting of 7 species of birds,19 species of bats,6 species of rodents and 1 species of tree-shrew as well as 8 myriapods were ***:Infestation rates of ticks,mesostigmatid mites and chiggers on animals examined were 24.3%,28.6%and 27.9%,*** on bats was low(1.5%) and none occurred on *** of ticks extracted were at immature stages(78.9%). Genera of ticks on animals were Amblyomma,Dermacentor,Haemaphysalis and *** granulatus was the only species of licks identified from the *** of ticks under vegetation revealed 54%adults leading to identification of 3 species of ticks.A total of 7 species of mesostigmatid mites were found.6 species were on rodent,Maxomys mrifer and another one species,Laelaps nuttalli was found only on Leopoldamys *** sanguisugus was the only mesostigmatid found infesting *** genera of chiggers were *** this,5 genera were on rodents,4 genera on tree-shrews and 1 genus on a ***:A total of 16 genera,2 sub-genus and 14 species of acarine ectoparasites were found in this area. Findings of the survey demonstrate the presence of three spesies of acarine ectoparasites which have potential health risk *** granulalus,Laelaps nuttalli and Leptotrombidium deliense.

关键词： Acarine ectoparasites Panti Forest Reserve Malaysia Public health risk Infestation rate Tick Mesostigmatid mite Chigger Ixodes granulatus Laelaps nuttalli Leptotrombidium deliense Avifauna Rodent

Latent tuberculosis infection among medical students in Malaysia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2019年第4期12卷 181-184页

作者： Maha Abdullah Ummi Nadira Daut Siti Aishah Daud nor Afifi mohd Romli Marsitah Abdul Jalil Noorelina Muhammad Safarina Mohammad Ismuddin Masriana Hassan Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia

Objective: This study aimed to determine prevalence of latent tuberculosis infection among medical students and tuberculosis exposure at the health facilities. Methods: A cross-section of study year 1(n=68) and year 5(n=75) medical students in a local university were recruited for latent tuberculosis infection testing using QuantiFERON-TB Gold Plus and a questionnaire analyzed for multivariate risk. Results: The majority of the study were vaccinated with BCG. None of year 1 medical students were positive for latent tuberculosis infection, however, six(8.0%) year 5 students were tested positive for latent tuberculosis infection. A higher incidence of year 5 medical students claimed to be exposed to tuberculosis at health facility(65.3% vs. 4.4%) and a higher percentage reported contact with tuberculosis case over the preceding year compared to year 1 students(30.7% vs. 8.8%). Conclusion: We observed a higher incidence of latent tuberculosis infection and higher exposure to tuberculosis in health facilities among year 5 medical students. Baseline screening and monitoring for progression to tuberculosis infection may benefit tuberculosis management programs.

关键词： Latent tuberculosis infection Medical students Interferon-gamma release assay

Connexin therapeutics:blocking connexin hemichannel pores is distinct from blocking pannexin channels or gap junctions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第3期16卷 482-488页

作者： Monica L.Acosta mohd N.Mat nor Cindy X.Guo Odunayo O.Mugisho Frazer P.Coutinho Ilva D.Rupenthal Colin R.Green School of Optometry and Vision Science University of AucklandAucklandNew Zealand Faculty of Medicine Universiti Sultan Zainal AbidinTerengganuMalaysia Department of Ophthalmology University of AucklandAucklandNew Zealand Buchanan Ocular Therapeutics Unit Department of OphthalmologyAucklandNew Zealand New Zealand National Eye Centre University of AucklandAucklandNew Zealand Centre for Brain Research Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Brain Research New Zealand–Rangahau Roro Aotearoa AucklandNew Zealand

Compounds that block the function of connexin and pannexin protein channels have been suggested to be valuable therapeutics for a range of *** of these compounds are now in clinical trials,but for many of them,the literature is inconclusive about the molecular effect on the tissue,despite evidence of functional *** the different channel types has distinct physiological and pathological implications and this review describes current knowledge of connexin and pannexin protein channels,their function as channels and possible mechanisms of the channel block effect for the latest therapeutic *** summarize the evidence implicating pannexins and connexins in disease,considering their homeostatic versus pathological roles,their contribution to excesive ATP release linked to disease onset and progression.

关键词： connexin gap junction gap19 hemichannel pannexin retina tonabersat

Rheological and MECHANICAL Performance of Asphalt Binders and Mixtures Incorporating CaCO3 and LLDPE

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Organic Polymer Material Research 2019年第1期1卷 10-21页

作者： mohd Rosli mohd Hasan Zhanping You mohd Khairul Idham mohd Satar Muhammad Naqiuddin mohd Warid nurul Hidayah mohd Kamaruddin Sharvin Poovaneshvaran School of Civil Engineering Universiti Sains MalaysiaEngineering Campus14300 Nibong TebalPulau PinangMalaysia Department of Civil and Environmental Engineering Michigan Technological University1400 Townsend Drive HoughtonMI 49931USA Department of Geotechnics and Transportation Faculty of Civil EngineeringUniversiti Teknologi Malaysia81310 Johor BahruJohorMalaysia Faculty of Civil and Environmental Engineering Universiti Tun Hussein Onn Malaysia86400 Parit RajaBatu PahatJohorMalaysia.

This study was conducted to assess the performance of modified asphalt binders and engineering properties of mixtures prepared with incorporation 3 vol%and 6 vol%of calcium carbonate(CaCO3),linear low-density polyethylene(LLDPE),and combinations of CaCO3 and *** rheological properties of control and modified asphalt binders were evaluated using a series of testing such as rotational viscometer(RV),multiple stress creep recovery(MSCR)and bending beam rheometer(BBR)***,four-point beam fatigue test,the dynamic modulus(E*)test and tensile strength ratio(TSR)test were conducted to assess the engineering properties of asphalt *** on the findings,the RV and MSCR test result shows that all modified asphalt binders have improved performance in comparison to the neat asphalt binders in terms of higher viscosity and improved permanent deformation resistance.A higher amount of CaCO3 and LLDPE have led modified asphalt binders to better recovery percentage,except the asphalt binders modified using a combination of CaCO3 and ***,the inclusion of LLDPE into asphalt binder has lowered the thermal cracking *** incorporation of CaCO3 in asphalt mixtures was found beneficial,especially in improving the ability to resist fatigue cracking of asphalt *** contrast,asphalt mixtures show better moisture sensitivity through the addition of *** addition of LLDPE has significantly enhanced the indirect tensile strength values and tensile strength ratio of asphalt mixtures.

关键词： Asphalt modification Binder rheology Mineral filler Mixture performance Plastic

Liposomes as immunological adjuvants and delivery systems in the development of tuberculosis vaccine:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2022年第1期15卷 7-16页

作者： Nur Ellene Mat Luwi Suhana Ahmad Ahmad Suhaimi Nurfatihah Azlyna Asyikin nordin Maria Elena Sarmiento Armando Acosta mohd nor norazmi Vuk Uskoković Rohimah Mohamud Ramlah Kadir Department of Immunology School of Medical SciencesUniversiti Sains Malaysia16150 Kubang KerianKelantanMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kubang KerianKelantanMalaysia Department of Mechanical Engineering San Diego State UniversityCampanile Dr.5500San Diego 921982CAUSA TardigradeNano LLC IrvineCA 92604USA

Liposomes are phospholipid bilayer vesicles,which are biocompatible,biodegradable and nontoxic vehicles suitable for numerous drug and gene delivery *** this review,we discuss the prospect of using liposome technology in the development of a vaccine for *** remains an important health problem that requires the development of an effective vaccine,especially since the only approved vaccine for it continues to be the Bacille Calmette-Geurin(BCG)one developed 100 years *** review focuses on the different applications of liposomes toward achieving this *** liposomal formulations showing prospect in the research stage and in clinical trials are discussed.

关键词： Liposomes Tuberculosis vaccine Adjuvant Delivery system Tuberculosis

Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2011年第2期30卷 144-148页

作者： Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay nor Azhari mohd Zam Puay Hoon Tan Min-Han Tan Department of Medical Oncology National Cancer Centre Singapore Singapore 169610 Republic of Singapore Department of Otolaryngology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Urology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Pathology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore.

Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.

关键词：风险分类肾细胞癌症预后鼻医院管理 CC标准治疗方案

The evolution of pneumococcal vaccine on children in Malaysia:the efficacy and outcome

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Infectious Diseases Research 2021年第4期2卷 11-21页

作者： Semiat Opeyemi Yusuff Siti norbaya Masri nurul Diana Dzaraly Niazlin mohd Taib mohd Nasir mohd Desa Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangor43400 UPMSerdangMalaysia Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPMSerdangSelangorMalaysia

With pathogenic bacterium,numerous studies have been conducted in developing new vaccines,and available pneumococcal vaccines have been implemented for the prevention of related ***,Streptococcus pneumoniae is known to have developed resistance to many of the proposed preventive *** a result,contemporary research,including our study,has reviewed how Streptococcus pneumoniae has become resistant to vaccines and to further determine how to prevent the negative effect of the non-vaccine serotype on vaccine serotype *** have been known as one of the bacteria that has highest preventive strength of vaccination provided to humans,where children’s immunity requires the vital of it,based on immunization schedule to boost their immune system against the diseases of high mortality and *** pneumococcal vaccines are derived from its strains called serotypes,and further research is being conducted to determine more potent vaccines from other pneumococcal virulence *** impose and implement the pneumococcal vaccine,the serotype distribution needs to be *** deal with this verification,clinical or carriage samples are required for the determination and differentiation of vaccine serotypes from non-vaccine *** Malaysia,the carriage rates are often limited to the clinical epidemiology of Streptococcus *** samples are more needed in tracking the vaccine efficacy for pre-and post-immunization to prevent and reduce pneumococcal diseases before they manifest into clinical ***,in this review article,we explore the mentioned highlights for sufficient discussion,discovery,and knowledgeable implementation of pneumococcal vaccine.

关键词： Streptococcus pneumoniae Serotype Vaccine Children Carriage Malaysia

Molecular Detection of Mutations within the Quinolone Resistance-Determining Regions in Non Typhoidal Salmonella Isolates from Malaysia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Health 2017年第4期9卷 640-648页

作者： Fadzilah mohd-nor Noor Aini Abu-Bakar norzilawati mohd-Isa Zubaidah A. Wahab Zaini mohd-Zain Microbiology Discipline Faculty of Medicine UniversitiTeknologi MARA Sg. Buloh Campus Jalan Hospital Sg. Buloh Selangor Malaysia Community of Research (CoRE) of Health & Wellbeing UniversitiTeknologi MARA Shah Alam Selangor Malaysia Microbiology Unit Department of Pathology Hospital Sg. Buloh Sg. Buloh Selangor Malaysia

Introduction: The efficacy of chemotherapy in bacteraemia caused by non-typhoidal Salmonella (NTS) is compromised by antibiotic resistance. Objective: This study was undertaken to describe the mechanism of resistance among clinical NTS isolates. Materials & Methodology: Thirty of NTS were isolated from blood (n = 19), stool (n = 10) and bronchioalveolar lavage (BAL;n = 1) respectively. These isolates were tested for susceptibility testing by disc diffusion method against ampicillin, gentamicin, tetracycline, co-trimoxazole, nalidixic acid, ciprofloxacin and ceftriaxone. Epsilometer tests (E-test) for nalidixic acid and ciprofloxacin were performed for nalidixic acid resistant isolates by disc diffusion method. DNA sequencing was carried out on six of the nalidixic acid resistant Salmonella Enteritidis isolates to identify mutations within quinolones resistance determining regions (QRDR) of gyrA, gyrB, parC and parE genes. Results: Resistance rates of NTS isolates from blood, stool, and BAL were respectively 37%, 20% and 0% for ampicillin, 79%, 40% and 0% for tetracycline, 32%, 40% and 0% for co-trimoxazole, 37%, 10% and 100% for nalidixic acid. Eight isolates were resistant to nalidixic acid and had exhibited reduced susceptibility towards ciprofloxacin by E-test. Mutation within QRDR was detected in gyrA gene (n = 6;Asp 47 → His [3], Asp 51 → Asn [1], Asp 73 → Gly [1], and Gly 48 → Asp [1]) and double mutation was detected in parE gene (n = 3;Gly 48 → Asp [3], Glu 82 → Ser [3]). Out of six isolates, three isolates were found to have both gyrA and parE gene mutations. Conclusions: There was no mutation observed in gyrB and parC gene. Mutation in gyrA gene was sufficient to induce decreased susceptibility to ciprofloxacin. Variation in amino acid sequences are novel, while detection of other gene mutation was uncommon.

关键词： Non-Typhoidal Salmonella Quinolones Resistance-Determining Regions Ciprofloxacin