The evolution of pneumococcal vaccine on children in Malaysia:the efficacy and outcome

作     者：Semiat Opeyemi Yusuff Siti Norbaya Masri Nurul Diana Dzaraly Niazlin Mohd Taib Mohd Nasir Mohd Desa 

作者机构：Department of Medical Microbiology and ParasitologyFaculty of Medicine and Health SciencesUniversiti Putra MalaysiaSelangor43400 UPMSerdangMalaysia Department of Biomedical SciencesFaculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 UPMSerdangSelangorMalaysia 

出 版 物：《Infectious Diseases Research》 (传染病研究（英文）)

年 卷 期：2021年第2卷第4期

页      面：11-21页

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

主　　题：Streptococcus pneumoniae Serotype Vaccine Children Carriage Malaysia 

摘      要：With pathogenic bacterium,numerous studies have been conducted in developing new vaccines,and available pneumococcal vaccines have been implemented for the prevention of related ***,Streptococcus pneumoniae is known to have developed resistance to many of the proposed preventive *** a result,contemporary research,including our study,has reviewed how Streptococcus pneumoniae has become resistant to vaccines and to further determine how to prevent the negative effect of the non-vaccine serotype on vaccine serotype *** have been known as one of the bacteria that has highest preventive strength of vaccination provided to humans,where children’s immunity requires the vital of it,based on immunization schedule to boost their immune system against the diseases of high mortality and *** pneumococcal vaccines are derived from its strains called serotypes,and further research is being conducted to determine more potent vaccines from other pneumococcal virulence *** impose and implement the pneumococcal vaccine,the serotype distribution needs to be *** deal with this verification,clinical or carriage samples are required for the determination and differentiation of vaccine serotypes from non-vaccine *** Malaysia,the carriage rates are often limited to the clinical epidemiology of Streptococcus *** samples are more needed in tracking the vaccine efficacy for pre-and post-immunization to prevent and reduce pneumococcal diseases before they manifest into clinical ***,in this review article,we explore the mentioned highlights for sufficient discussion,discovery,and knowledgeable implementation of pneumococcal vaccine.