Nasal metastases from renal cell carcinoma are associated with Memorial Sloan-Kettering Cancer Center poor-prognosis classification

作     者：Caroline Victoria Choong Tiffany Tang Wen Yee Chay Christopher Goh Miah Hiang Tay Nor Azhari Mohd Zam Puay Hoon Tan Min-Han Tan 

作者机构：Department of Medical Oncology National Cancer Centre Singapore Singapore 169610 Republic of Singapore Department of Otolaryngology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Urology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore Department of Pathology Singapore General Hospital Singapore Singapore 169608 Republic of Singapore. 

出 版 物：《Chinese Journal of Cancer》 (Chin. J. Cancer)

年 卷 期：2011年第30卷第2期

页      面：144-148页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：风险分类 肾细胞 癌症 预后 鼻 医院管理 CC标准 治疗方案 

摘      要：Unusual sites of metastases are recognized in patients with renal cell carcinoma (RCC). However, the prognostic implications of these sites are not well understood. We used the Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification for metastatic RCC to evaluate 912 consecutive patients with RCC managed at the Singapore General Hospital between 1990 and 2009. Among these patients, 301 had metastases either at diagnosis or during the course of illness. Nasal metastases, all arising from clear cell RCC, were identified histologically in 4 patients (1.3% of those with metastasis). All 4 patients were classified as MSKCC poor prognosis by current risk criteria. Nasal metastases were significantly associated with lung and bone metastases. The frequency of nasal metastases in patients with metastatic RCC is about 1%, occurring predominantly in patients with clear cell RCC. Nasal metastases are associated with poor prognosis as estimated by the MSKCC risk classification, with attendant implications for selection of targeted therapy, and are usually associated with multi-organ dissemination, including concurrent lung and bone involvement.