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Aluminum exposure and toxicity in neonates:a practical guide to halt aluminum overload in the prenatal and perinatal periods

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World Journal of Pediatrics 2014年第2期10卷 101-107页

作者： Daniela Fanni Rossano Ambu Clara Gerosa Sonia Nemolato nicoletta iacovidou Peter Van Eyken Vassilios Fanos Marco Zaffanello Gavino Faa Department of Pathology University Hospital San Giovanni di DioAOU Cagliari and University of CagliariItaly National and Kapodistrian University of Athens Medical SchoolAthensGreece Department of Pathology K.U.LeuvenLeuvenBelgium Neonatal Intensive Care Unit Puericulture Institute and Neonatal SectionAOU Cagliari and University of CagliariItaly Department of Pediatrics University of VeronaItaly

Background:During the last years,human newborns have been overexposed to biologically reactive aluminum,with possible relevant consequences on their future health and on their susceptibility to a variety of ***,newborns and particularly preterm neonates are at an increased risk of aluminum toxicity because of their relative *** sources:Based on recent original publications and classical data of the literatures,we reviewed the aluminum content in mother's food during the intrauterine life as well as in breast milk and infant formula during *** also determined the possible role of aluminum in parenteral nutrition solutions,in adjuvants of vaccines and in pharmaceutical products.A special focus is placed on the relationship between aluminum overexposure and the insurgence of bone ***:Practical points of management and prevention are *** sources that infants may receive during the fi rst 6 months of life are *** the context of prevention of possible adverse effects of aluminum overload in fetal tissues during development,simple suggestions to pregnant women are ***,practical points of management and prevention are ***:Pediatricians and neonatologists must be more concerned about aluminum content in all products our newborns are exposed to,starting from monitoring aluminum concentrations in milk-and soybased formulas in which,on the basis of recent studies,there is still too much aluminum.

关键词： aluminum fetus newborn toxicity

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Histopathology of renal asphyxia in newborn piglets: Individual susceptibility to tubular changes

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World Journal of Nephrology 2015年第2期4卷 313-318页

作者： Clara Gerosa nicoletta iacovidou Ioanna Argyri Daniela Fanni Apostolos Papalois Filippia Aroni Gavino Faa Theodoros Xanthos Vassilios Fanos Department of Pathology University of Cagliari National and Kapodistrian University of Athens ELPEN Research-Experimental Center Laboratory of Experimental Surgery and Surgical Research University of Athens Department of Neonatology University of Cagliari

OBJECTIVE:To analyze the effects on the kidney of hypoxia-reoxygenation in an experimental model of normocapnic asphyxia.;METHODS:To this end, 40 newborn Landrace/Large-White piglets aged 1-4 d were studied in this work. Hypoxia was induced by decreasing the inspired fiO2 to 0.06-0.08. Animals were resuscitated with different fiO2 and subdivided into 4 groups: group 1, 2, 3 and 4 received 18%, 21%, 40% and 100% O2 respectively. Macroscopic examination was carried out to evidence possible pathological features. Tissue sample were obtained from both kidneys. Four or five micron paraffin sections were stained with H-E and PAS stain and examined under an optical microscope.;RESULTS:Pathological changes, mainly affecting tubular cells, were observed in the vast majority of kidneys of asphyxiated piglets. The most frequent tubular changes were: tubular casts (95%), tubular dilatation (87.5%), tubular vacuolization (70%), tubular eosinophilia (52.5%), sloughing (50%), fragmentation of the brush border (50%), oedema (32.5%), apoptosis (15%) and glomerular changes (meningeal cell proliferation, capsular adhesion between the flocculus and Bowman's capsule, glomerulosclerosis and fibrous or cellular crescents associated with collapse of the glomerular tuft). Statistical analysis was carried out on changes observed when the animals were allocated in the 4 groups (χ(2)-test 0.05). The statistical analysis showed no evidence of differences regarding kidney lesions among the animals groups.;CONCLUSIONS:Our data show that renal pathology in newborn piglets is characterized by interindividual variability to hypoxia and is not associated with oxygen concentration.

关键词：窒息模型肾脏肾病治疗方法

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Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [Gene Dis (10) (2023),1187–1189]

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Genes & Diseases 2024年第2期11卷 1084-1084页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo nicoletta Resta Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J) University of Bari Aldo Moro Bari 70124 Italy

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A rare case of epiploic appendagitis in a patient affected by ulcerative colitis on vedolizumab therapy

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Gastroenterology Report 2022年第1期10卷 661-664页

作者： Daniela Pugliese Giuseppe Privitera Luigi Larosa Valentin Calvez Diana Broglia nicoletta de Matthaeis Alessandro Armuzzi CEMAD IBD UNITUnita Operativa Complessa di Medicina Interna e GastroenterologiaDipartimento di Scienze Mediche e ChirurgicheFondazione Policlinico Universitario“A.Gemelli”IRCCSRomeItaly Dipartimento Universitario di Medicina e Chirurgia Traslazionale Universita Cattolica del Sacro CuoreRomeItaly Fondazione Policlinico Universitario A.Gemelli IRCCS UOC di Radiodiagnostica Presidio ColumbusDipartimento di Diagnostica per immaginiRadioterapia Oncologica ed EmatologiaLargo Francesco VitoRomeItaly Universita Cattolica del Sacro Cuore RomeItaly IBD Center IRCCS Humanitas Research HospitalRozzanoMilanItaly Department of Biomedical Sciences Humanitas UniversityPieve EmanueleMilanItaly

Introduction Epiploic appendagitis(EA)is an acute inflammation of the pedunculated mesenteric fat attached to the colonic surface,distinguished into two forms:primary EA,seemingly elicited by local ischaemic factors;and secondary EA(SEA),elicited by the inflammation of the adjacent organs,with diverticulitis being the most common trigger[1].Few case series have described the association between SEA and inflammatory bowel disease(IBD);however,information about clinical,laboratory and imaging findings,outcomes,and the impact of IBD-specific therapy were not *** first report the case of a woman affected by ulcerative colitis(UC)who developed a SEA during vedolizumab therapy(Figure 1A).

关键词： inflammation organs acute

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Down-regulation of DPH2L gene during cellular differentiation/apoptosis:Use of mRNA differential display

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Chinese Science Bulletin 1999年第6期44卷 496-503页

作者： nicoletta Ferrari Giovanni Levi Laboratory of Molecular Biology National Institute for Cancer ResearchLaboratory of Molecular Biology National Institute for Cancer Research Genova Italy Genova Italy

To characterize the genes associated with differentiation/apoptosis induced by all-trans retinoic acid (ATRA) in human lung cancer cells, mRNA differential display was employed. Six cDNA fragments have been isolated, and one of them corresponds to a sequence-known gene DPH2L with unknown function, which was first isolated from the critical region of deletion on chromosome 17p13.3 in human ovarian carcinoma, and regarded as a candidate tumor suppressor gene. Results show that DPH2L is a wide expressed gene, and has another major transcript besides the previously reported 2.3 kb transcript. It is proved that the DPH2L gene is dawn-regulated during differentiation or apoptosis in several kinds of cancer cells induced by all-trans retinoic acid and N-(4-hydroxyphenyl) retinamide (4HPR). This may suggest that DPH2L does not play a role as a tumor suppressor gene, on the contrary, its down-regulation may be functionally involved in the transition from cell growth to differentiation or apoptosis.

关键词： mRNA differential display retinoic acids cell differentiation apoptosis tumor suppressor gene.

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Helicobacter pylori:a foodborne pathogen?

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World Journal of Gastroenterology 2018年第31期24卷 3472-3487页

作者： nicoletta C Quaglia Angela Dambrosio Department of Emergency and Organ Transplantation Section of Veterinary Clinic and Animal ProductionUniversity of Bari "Aldo Moro"

Helicobacter pylori(H. pylori) is an organism that is widespread in the human population and is sometimes responsible for some of the most common chronic clinical disorders of the upper gastrointestinal tract in humans, such as chronic-active gastritis, duodenal and gastric ulcer disease, low-grade B-cell mucosa associated lymphoid tissue lymphoma of the stomach, and gastric adenocarcinoma, which is the third leading cause of cancer death worldwide. The routes of infection have not yet been firmly established, and different routes of transmission have been suggested, although the most commonly accepted hypothesis is that infection takes place through the faecal-oral route and that contaminated water and foods might play an important role in transmission of the microorganism to humans. Furthermore, several authors have considered H. pylori to be a foodborne pathogen because of some of its microbiological and epidemiological characteristics. H. pylori has been detected in drinking water, seawater, vegetables and foods of animal origin. H. pylori survives in complex foodstuffs such as milk, vegetables and ready-to-eat foods. This review article presents an overview of the present knowledge on the microbiological aspects in terms of phenotypic characteristics and growth requirements of H. pylori, focusing on the potential role that foodstuffs and water may play in the transmission of the pathogen to humans and the methods successfully used for the detection of this microorganism in foodstuffs and water.

关键词： Helicobacter pylori Viable but nonculturable state Foodborne pathogen Food Water Animal reservoirs Culture methods Molecular methods

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Effects of Plasmodium falciparum—infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

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Asian Pacific Journal of Tropical Medicine 2013年第3期6卷 195-199页

作者： Sarah D' Alessandro nicoletta Basilico Mauro Prato Dipartimento di Sanita Pubblica-Microbiologia-Virologia Universita di MilanoMilanoItaly Dipartimento di Genetica Biologia e BiochimicaFacolta di Medicina e ChirurgiaUniversita di TorinoTorinoItaly

Objective:To investigate the regulation of matrix metalloproteinases(MMPs) and tissue inhibitors of melalloproleinases(TIMPs) in human microvascular endothelium(HMEC-1) exposed to erythrocytes infected by different strains of Plasmodium falciparum(***).Methods: HMEC—1 eells were co—incubated for 72 h with erythrocytes infected by late stage trophozoite of D10(chloroquine-sensilive) or W 2(chloroquine-resistant) *** *** supernatants were then collected and the levels of pro- or active gelatinases MMP-9 and MMP-2 were evaluated by gelatin zymograpln and *** release of pro-MMP-9,***-1 and TIMP-1 proteins was analyzed by western blotting and ***:Infected erythrocytes induced de novo proMMP-9 and MMP-9 *** basal levels of proMMP-2 were altered,nor active MMP-2 was ***-3 and MMP-1 secretion was significant!) enhanced,whereas basal TIMP-1 was *** effects were similar for both strains. Conclusions:*** parasites,either chloroquine-sonsitive or -resistant,induce the release of active MMP-9 protein from human microvascular endothelium,by impairing balances between proMMP-9 and its inhibitor,and by enhancing the levels of its *** work provides new evidence on MMP involvement in malaria,pointing at MMP-9 as a possible target in adjuvant therapy.

关键词： Plasmodium falciparum Malaria Endothelial cells Matrix metalloproteinases Tissue inhibitors of metalloproteinases Gelatinases

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Sexual Behavior and Awareness of Sexually Transmitted Diseases Among Street-Based Female Sex Workers in the Florence Area, Central Italy

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International Journal of Dermatology and Venereology 2022年第4期5卷 226-230页

作者： Barbara Giomi Caterina Silvestri Stefano Bravi Cristina Stasi Lisa Bertini Leslie Mechi Serena Mordini nicoletta Zocco Fabio Voller Francesco Cipriani Unit for STD and AIDS Department of DermatologyUniversity of FlorenceFlorence 50134Italy Observatory of Epidemiology Regional Health Agency of TuscanyFlorence 50141Italy Interdepartmental Hepatology Center MASVE Department of Experimental and Clinical MedicineUniversity of FlorenceFlorence 50134Italy CAT Social Cooperative Road Unit SATIS Regional Project Florence 50134Italy Department of Prevention Central Tuscany Local UnitFlorence 50135Italy.

Objective:Street-based female sex workers are more likely to practice unprotected sex with multiple partners increases their risk of infection with sexually transmitted *** study was performed to evaluate the understanding of and risk factors for sexually transmitted diseases among street-based female sex ***:A survey consisted of a sociodemographic section and a health section was conducted from June to August in two consecutive years(2012-2013)using an anonymous questionnaire compiled by street-based female sex workers in the area of Florence(Central Italy).A descriptive analysis of sociodemographic,epidemiological,and anamnestic variables was performed using common methods for proportions;associations between variables were assessed using univariate and bivariate logistic ***:Totally 122 street-based female sex workers(mean age,24.1 years;age range,17-45 years)were enrolled,and were from Europe(63.1%)(mainly from Romania[48.4%]and Albania[13.1%]),Africa(31.2%)(specifically Nigeria),and South America(5.7%).Of the 122 street-based female sex workers,63%were married/engaged and 37%were *** than half had been living in Italy and Florence for more than 1 year;72.8%stated that they possessed a residence permit and the others were illegal ***(15%)street-based female sex workers also worked in the industry in neighboring European *** level of education was generally high:58.1%had completed secondary school(lower secondary school and upper secondary school).A total of 81.4%stated that they perceived an actual fear of contracting human immunodeficiency virus;in fact,43.3%had never been tested for any sexually transmitted diseases except for human immunodeficiency ***:Despite the long-time involvement of street-based female sex workers in the commercial sex industry,the large numbers of clients and a strong perception of concerns about sexually transmitted *** study confirms a low

关键词： female sex street workers foreigners sexually transmitted diseases

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Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes

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Genes & Diseases 2023年第4期10卷 1187-1189页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi Katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo nicoletta Resta b Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area(DiMePRe-J)University of Bari Aldo MoroBari 70124Italy

Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition *** is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polyposis coli(AP... 详细信息

关键词： polyposis adenomatous colon

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Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications

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Chinese Science Bulletin 2012年第31期57卷 3961-3971页

作者： MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio Department of Nanomedicine The Methodist Hospital Research Institute Graduate School of Biomedical Sciences The University of Texas at Houston

Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects.

关键词：生物医学应用纳米粒子多功能传递系统演变多级药物控制释放纳米载体

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