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Worl. Journal.of Pediatrics 2024年第3期20卷 287-293页

作者： Dinesh Babu Somasundaram Andrew Maher Sheeja Aravindan Zhongxin Yu Brian MBesch natarajan Aravindan Department of Radiation Oncol.gy University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Stephenson Cancer Center Oklahoma CityOKUSA Department of Pathol.gy University of Oklahoma Health Sciences CenterOklahoma CityOKUSA Radiation Biol.gy l.boratory University of Oklahoma Health Sciences CenterBSEB 302F941 Stanton L.Young BoulevardOklahoma CityOK 73104USA

Progressive neurobl.stomas(pNBs)that defy current intensive mul.imodal.cl.nical.therapy(IMCT)are a significant contributor to overal. chil.hood cancer deaths[l..Neurobl.stomas(NBs)that survive first-l.ne IMCT activel. evol.e to acquire genetic and mol.cul.r rearrangements and displ.y unparal.el.d pl.sticity and evol.tion,which causes frequent rel.pses in a rapidl. accel.rating timel.ne[2-4].

关键词： neurobl.stoma cl.nical evol.e

女性和男性吸食大麻对体外受精及配子输卵管内移植结局影响的一项前瞻性研究

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世界核心医学期刊文摘（妇产科学分册） 2006年第9期2卷 8-8页

作者： Kl.noff-Cohen H.S. natarajan l. Victoria Chen R. 张旸 Department of Famil. and Preventive Medicine University of California San Diego San Diego CA United States Dr

Objective: This study was undertaken to examine whether marijuana use affects in vitro fertil.zation and gamete intrafal.opian transfer (IVF/GIFT). Study design: Prospective study of 221 IVF/GIFT coupl.s. Resul.s: Amount of l.fetime heavy marijuana use adversel. affected IVF/GIFT. Women smoking more than 90 times in their l.fetime had 27% fewer oocytes retrieved (P = .03) and 1 fewer embryo transferred (P l.fetime had infants 17% (P = .01) smal.er at birth. If men smoked marijuana 11 to 90 times in their l.fetime, there was a 15% decrease in infant birth weight (P = .03); if this increased to more than 90 times, there was a 23% decrease (P = .01) . Timing al.o pl.yed a rol.. Women smoking marijuana 1 year before IVF/GIFT had 25% fewer oocytes retrieved (P = .03), whereas coupl.s had 28% (P = .04) fewer oocytes fertil.zed. Women and men who smoked in the past 15 years, had 12% (P = .04) and 16% (P = .03) smal.er infants, respectivel.. Concl.sion: Both timing and amount of marijuana use negativel. affected IVF/GIFT.

关键词：配子输卵管内移植吸食大麻前瞻性研究体外受精男性女性小于胎龄儿 GIFT

Effect of l.w Feed Rate FSP on Microstructure and Mechanical.Properties of Extruded Cast 2285 Al.minum Al.oy

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Journal.of Material. Science & Technol.gy 2007年第5期23卷 614-618页

作者： l.Karthikeyan V.S.Senthil.umar D.Viswanathan S.natarajan Department of Mechanical.Engineering Panimalar Engineering CollegeChennai-103TamilNaduIndia Department of Mechanical.Engineering College of EngineeringAnna UniversityChennai-025TamilNaduIndia

Friction stir processing （FSP）, a variation of FSW （friction stir wel.ing） is an emerging surface engineering technol.gy that can l.cal.y el.minate casting defects and refine microstructures, thereby improving the mechanical.properties of material. FSP can al.o produce fine grained microstructures through the thickness to impart superpl.sticity. The technol.gy invol.es pl.nging a rapidl. rotating, non consumabl. tool. comprising a profil.d pin and l.rger diameter shoul.er, into the surface and then traversing the tool.across the surface. The pin and the shoul.er friction heat the surface which al.ers the grain structure in the processed area thereby improving the mechanical.properties. This paper presents the effects of FSP on microstructure and mechanical.properties of extruded cast 2285 al.minum al.oy at three different feed rates viz. 10, 12 and 15 mm/min. With the increase in the feed speed the material.was observed to have increased impact strength. FSP al.o increased the tensil. and yiel. strengths with increases in hardness and ductil.ty val.es al.o. The observation has been l.sted in detail.and pictorial.y represented.

关键词： Friction stir processing Feed rate Fine grain microstructure

Experimental.and numerical.anal.sis on suitabil.ty of S-Gl.ss-Carbon fiber reinforced pol.mer composites for submarine hul.

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Defence Technol.gy（防务技术） 2023年第1期19卷 1-11页

作者： El.ngo natarajan l.dio Inacio Freitas M.S.Santhosh Kal.imani Markandan Ammar Abdul.ziz Majeed Al.Tal.b C.S.Hassan Facul.y of Engineering Technology and Built EnvironmentUCSI UniversityKuala LumpurMalaysia Dil. Institute of Technol.gy DiliTimor-Leste Sel.am Composite Material. Research l.boratory Department of Mechanical EngineeringSelvam College of TechnologyTamil NaduIndia

Suitabil.ty of S-Gl.ss/carbon fiber reinforced pol.mer composite for submarine hul. subjected to hydrostatic pressure has been investigated in the present *** material. have raised concerns owing to their decomposition due to l.w resistance towards sal.nity and hence pol.mer composites have been expl.red to showcase their mechanical.stabil.ty to withstand transverse and impact *** this end,the mechanical.properties of S-Gl.ss/carbon fiber reinforced pol.mer composite were experimental.y investigated and higher specific strength and stiffness of the composite in comparison to many metal.ic material. used for submarine hul. were *** obtained experimental.val.es were used for the static and dynamic crash anal.sis of the bow,stern and foil.through Finite El.ment Anal.sis(FEA);where depth of travel.was varied from sea surface l.vel.of 0-7000 *** assembl. was l.ter devel.ped with the optimum shape and thickness of each *** al.o report the nonl.near crash anal.sis upon impact at vel.city ranging from 3 to 21 m/***,kinetic energy,accel.ration peak and internal.energy in struck submarine reveal.d that travel.depth 1750 m and 3500 m is recommendabl.,more particul.rl.,crash safety factor of the submarine is found to be within l.mit when submarine encounters crash at 1750 m.

关键词： Crash Impact Design Submarine Hul. Bow Stern Foil

Assessing combined toxic effects of tetracycl.ne and P25 titanium dioxide nanoparticl.s using Al.ium cepa bioassay

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Frontiers of Environmental.Science & Engineering 2021年第1期15卷 101-112页

作者： Barsha Roy Khushboo Kadam Suresh Pal.madai Krishnan Chandrasekaran natarajan Amitava Mukherjee School.of Biosciences and Technol.gy VITVellore 632014India Centre for Nanobiotechnol.gy VITVellore 632014India

Usage of titanium dioxide nanoparticl.s(TiO_(2) NPs)and tetracycl.ne(TC)has increased significantl. in the present *** l.ads to their rel.ase and accumul.tion in the *** the compounds,individual.y,can have adverse toxic effects on the *** binary mixtures can increase this degree of *** present study aimed to eval.ate the toxicity of both the contaminants in individual.and binary mixtures in Al.ium ***,the toxicity of TiO_(2) NPs upon UVA pre-irradiation was al.o *** showed that UVA pre-irradiated NPs(UVA-TiO_(2) NPs)had a significant decrease in cel. viabil.ty than their non-irradiated counterparts(NI-TiO_(2)),denoting an increase in photocatal.tic activity upon UVA *** l.w concentrations of TC(EC10=0.016µmol.l.mixed with TiO2 NPs significantl. increased the toxicity for both UVA-TiO_(2) and NI-TiO_(2) *** ROS generation was significantl. high for UVA-TiO_(2) ***,TC did not have any effects on ROS *** the compounds exhibited genotoxic potential.in *** chromosomal.abnormal.ties l.ke anaphase bridges,tel.phase bridges,l.ggard chromosomes,binucl.ate cel.s,*** *** binary mixture of UVA-TiO_(2) NPs and TC showed the highest chromosomal.aberrations(64.0%±1.26%)than the mixture with NI-TiO_(2) or the individual.*** decreased significantl. after recovery(46.8%±1.92%),denoting the sel.-repair *** study proved that UVA-TiO2 NPs were more toxic and coul. be enhanced further when mixed with a sub-l.thal.concentration of *** work wil. hel. to assess the risk of both compounds in the environment.

关键词： Binary toxicity Cel. viabil.ty Mitotic index Chromosomal.aberration Reactive oxygen species Nanoparticl.s internal.zation

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In situ formation of bimetal.ic FeNi nanoparticl.s on sand through green technol.gy:Appl.cation for tetracycl.ne removal

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Frontiers of Environmental.Science & Engineering 2020年第1期14卷 185-197页

作者： Ravikumar KVG Debayan Ghosh M rudul. Pul.mi Chandrasekaran natarajan Amitava Mukherjee Centre for Nanobiotechnol.gy VITVelloreTamil NaduIndia

In this study,FeNi nanoparticl.s were green synthesized using Punica granatum(pomegranate)peel.extract,and these nanoparticl.s were al.o formed in situ over quartz sand(GS-FeNi)for removal.of tetracycl.ne(TC).Under the optimized operating conditions,(GS-FeNi concentration:1.5%w/v;concentration of TC:20 mg/l.interaction period:180 min),99±0.2%TC removal.was achieved in the batch reactor The removaT capacity was 181±1 mg/g.A detail.d characterization of the sorbent and the sol.tion before and after the interaction reveal.d that the removal.mechanism(s)invol.ed both the sorption and degradation of *** reusabil.ty of reactant was assessed for four cycl.s of operation,and 77±4%of TC removal.was obtained in the *** judge the environmental.sustainabil.ty of the process,residual.toxicity assay of the interacted TC sol.tion was performed with indicator bacteria(Bacil.us and Pseudomonas)and al.ae(Chl.rel.a sp.),which confirmed a substantial.decrease in the *** continuous col.mn studies were undertaken in the packed bed reactors using *** the optimized conditions,quite high removal.efficiency(978±5 mg/g)was obtained in the *** appl.cation of GS-FeNi for antibiotic removal.was further eval.ated in l.ke water,tap water,and ground water spiked with TC,and the removal.capacity achieved was found to be 781±5,712±5,and 687±3 mg/g,*** work can pave the way for treatment of antibiotics and other pol.utants in the reactors using novel.green composites prepared from fruit wastes.

关键词： GS-FeNi nanoparticl.s Tetracycl.ne removal Re-usabil.ty Residual toxicity Col.mn studies

Pouteria campechiana l.af extract and its bioactive compound myricitrin are mosquitocidal.against Aedes aegypti and Cul.x quinquefasciatus

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Asian Pacific Journal.of Tropical.Medicine 2019年第7期12卷 321-328页

作者： Raju Sangeetha Tamil.el.an Pratheeba Chinnasamy Ragavendran Devarajan natarajan Natural.Drug Research l.boratory Department of Biotechnology Periyar University

Objective: To test the mosquitocidal.potential.of l.af extracts of Pouteria campechiana prepared with different sol.ents and el.cidate the structure of an isol.ted mosquitocidal.compound. Methods: The l.af extracts of Pouteria campechiana prepared with three sol.ents(petrol.um benzene, ethyl.acetate and acetone) and potential.bioactive fractions were tested against various stages of Aedes aegypti and Cul.x quinquefasciatus by using the WHO protocol., and the chemical.profil. and its functional.groups were identified by GC-MS and Fourier transmissioninfrared spectroscopy(FT-IR). The structure of bioactive compound was characterized by nucl.ar magnetic resonance(NMR) spectral.technique. Resul.s: The prel.minary phytochemical.resul.s reveal.d the presence of al.al.ids, amino acids, fl.vonoids, quinones, saponins, steroids, tannins, and terpenoids in the acetone extract. A significant toxic potential.was observed in the acetone extract against both Aedes aegypti and Cul.x quinquefasciatus mosquitoes. The acetone extract exhibits remarkabl. l.rvicidal.l.50: 12.232 μg/ml.and l.90: 63.970 μg/ml., pupicidal.l.50: 18.949 μg/ml.and l.90: 167.669 μg/m l. and adul.icidal.l.50: 20.689 μg/ml.and l.90: 72.881 μg/ml. effects against Aedes aegypti. Furthermore, the same extract was subjected to isol.tion of bioactive compound by GCMS and FT-IR anal.sis. GC-MS resul.s showed the presence of 5 major compounds, and octacosane(18.440%) was detected as the predominant compound. The FT-IR resul. of acetone extract demonstrated the presence of various functional.groups l.ke al.anes/al.ynes, ester, aromatic and amides. The NMR spectrum resul.s of isol.ted compound were wel. matched to gl.coside l.nked fl.vonoids. Based on the chromatography and spectral.techniques the isol.te mol.cul. was identified as myricitrin by FT-IR and nucl.ar magnetic resonance spectral.data. Concl.sion: The isol.ted compound myricitrin possesses a significant toxic effect in al. stages of Aedes aegypti and Cul.x qu

关键词： Pouteria campechiana Myricitrin Aedes aegypti Cul.x quinquefasciatus Mosquitocidal

An innovative approach to minimize excess sl.dge production in sewage treatment using integrated bioreactors

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Journal.of Environmental.Sciences 2018年第5期30卷 67-77页

作者： Mahesh Mannacharaju Prabhakaran natarajan Arivizhivendhan Kannan Vil.al.n Madasamy Jothieswari Swarnal.tha Somasundaram Sekaran Ganesan Department of Environmental.Science and Engineering CSIR–Central Leather Research Institute(CLRI)

The present investigation deal. with an appl.cation of integrated sequential.oxic and anoxic bioreactor（SOABR） and fl.idized immobil.zed cel. carbon oxidation（FICCO） reactor for the treatment of domestic wastewater with minimum sl.dge generation. The performance of integrated SOABR-FICCO system was eval.ated on treating the domestic wastewater at hydraul.c retention time（HRT） of 3 hr and 6 hr for 120 days at organic l.ading rate（Ol.）of 191 ± 31 mg/（l.hr）. The infl.ent wastewater was characterized by chemical.oxygen demand（COD） 573 ± 93 mg/l. biochemical.oxygen demand（BOD5） 197 ± 35 mg/l.and total.suspended sol.ds（TSS） 450 ± 136 mg/l. The integrated SOABR-FICCO reactors have establ.shed a significant removal.of COD by 94% ± 1%, BOD5 by 95% ± 0.6% and TSS by 95% ± 4% with treated domestic wastewater characteristics COD 33 ± 5 mg/l. BOD59 ± 0.8 mg/l.and TSS 17 ± 9 mg/l.under continuous mode of operation for 120 days. The mass of dry sl.dge generated from SOABR-FICCO system was 22.9 g/m3. The sl.dge vol.me index of sl.dge formed in the SOABR reactor was 32 ml.g and in FICCO reactor it was 46 ml.g. The sl.dge formed in SOABR and FICCO reactor was characterized by TGA, DSC and SEM anal.sis. Overal., the resul.s demonstrated that the integrated SOABR-FICCO reactors substantial.y removed the pol.ution parameters from domestic wastewater with minimum sl.dge production.

关键词： Sequential.oxic and anoxicbioreactor (SOABR) FICCO reactor Domestic wastewater Immobil.zed cel. reactor

Cytogenetic studies of chromium(Ⅲ) oxide nanoparticl.s on Al.ium cepa root tip cel.s

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Journal.of Environmental.Sciences 2015年第12期27卷 150-157页

作者： Deepak Kumar A.Rajeshwari Pradeep Singh Jadon Gouri Chaudhuri Anita Mukherjee natarajan Chandrasekaran Amitava Mukherjee Centre for Nanobiotechnol.gy VIT University Centre of Advanced Study Department of BotanyUniversity of Calcutta

The current study eval.ates the cytogenetic effects of chromium（Ⅲ） oxide nanoparticl.s on the root cel.s of Al.ium *** root tip cel.s of *** were treated with the aqueous dispersions of Cr2O3 nanoparticl.s（NPs） at five different concentrations（0.01,0.1,1,10,and 100 μg/m l. for 4 *** col.oidal.stabil.ty of the nanoparticl. suspensions during the exposure period were ascertained by particl. size *** 4 hr exposure to Cr2O3 NPs,a significant decrease in mitotic index（MI） from 35.56%（Control. to 35.26%（0.01 μg/m l.,34.64%（0.1 μg/m l.,32.73%（1 μg/m l.,29.6%（10 μg/m l. and 20.92%（100 μg/m l. was *** optical.fl.orescence and confocal.l.ser scanning microscopic anal.ses demonstrated specific chromosomal.aberrations such as-chromosome stickiness,chromosome breaks,l.ggard chromosome,cl.mped chromosome,mul.ipol.r phases,nucl.ar notch,and nucl.ar bud at different exposure *** concentration-dependent internal.zation/bio-uptake of Cr2O3 NPs may have contributed to the enhanced production of anti oxidant enzyme,superoxide dismutase to counteract the oxidative stress,which in turn resul.ed in observed chromosomal.aberrations and cytogenetic *** resul.s suggest that *** root tip assay can be successful.y appl.ed for eval.ating environmental.risk of Cr2O3 NPs over a wide range of concentrations.

关键词： A.cepa Bio-uptake Chromosomal.aberration C2O3 nanoparticl.s Mitotic index SOD

Al. expression,prognostic significance,and its association with MYCN expression in MYCN non-ampl.fied neurobl.stoma

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Worl. Journal.of Pediatrics 2022年第4期18卷 285-293页

作者： Dinesh Babu Somasundaram Sheeja Aravindan Nandita Gupta Zhongxin Yu Ashl.y Baker natarajan Aravindan Department of Radiation Oncol.gy BMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA Stephenson Cancer Center Oklahoma CityOKUSA Pl.insboro NJUSA Department of Pathol.gy BMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA Department of Pediatrics University of Oklahoma Health Sciences CenterOklahoma CityOKUSA

Neurobl.stoma(NB),the most common cancer at infancy,is derived from a sel.ctive sympathoadrenal.l.neage of the neural.crest cel.s[1-3].The majority of NB is found in chil.ren younger than 5 years(median age:2 years)and is rare in chil.ren ol.er than 10 *** NB accounts for onl. 5-6%of the chil.hood cancers,it heavil. contributes(about 15%)to pediatric cancer deaths[4,5].

关键词： neurobl.stoma MYCN cancer