ALK expression,prognostic significance,and its association with MYCN expression in MYCN non-amplified neuroblastoma

作     者：Dinesh Babu Somasundaram Sheeja Aravindan Nandita Gupta Zhongxin Yu Ashley Baker Natarajan Aravindan Dinesh Babu Somasundaram;Sheeja Aravindan;Nandita Gupta;Zhongxin Yu;Ashley Baker;Natarajan Aravindan

作者机构：Department of Radiation OncologyBMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA Stephenson Cancer CenterOklahoma CityOKUSA PlainsboroNJUSA Department of PathologyBMSB 311CRadiation Biology LaboratoryUniversity of Oklahoma Health Sciences Center940 Stanton L.Young BoulevardOklahoma CityOK 73104USA Department of PediatricsUniversity of Oklahoma Health Sciences CenterOklahoma CityOKUSA 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2022年第18卷第4期

页      面：285-293页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was partially or in full funded by the Oklahoma Center for the Advancement of Science and Technology(No.OCAST-HR19-045) National Institutes of Health(No.NIH-P20GM103639) NIH-NCI Cancer Center Support Grant(No.P30CA225520) 

主　　题：neuroblastoma MYCN cancer 

摘      要：Neuroblastoma(NB),the most common cancer at infancy,is derived from a selective sympathoadrenal lineage of the neural crest cells[1-3].The majority of NB is found in children younger than 5 years(median age:2 years)and is rare in children older than 10 *** NB accounts for only 5-6%of the childhood cancers,it heavily contributes(about 15%)to pediatric cancer deaths[4,5].