女性和男性吸食大麻对体外受精及配子输卵管内移植结局影响的一项前瞻性研究

作     者：Klonoff-Cohen H.S. Natarajan L. Victoria Chen R. 张旸 

作者机构：Department of Family and Preventive Medicine University of California San Diego San Diego CA United States Dr 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第9期

页      面：8-8页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：配子输卵管内移植 吸食大麻 前瞻性研究 体外受精 男性 女性 小于胎龄儿 GIFT 

摘      要：Objective: This study was undertaken to examine whether marijuana use affects in vitro fertilization and gamete intrafallopian transfer (IVF/GIFT). Study design: Prospective study of 221 IVF/GIFT couples. Results: Amount of lifetime heavy marijuana use adversely affected IVF/GIFT. Women smoking more than 90 times in their lifetime had 27% fewer oocytes retrieved (P = .03) and 1 fewer embryo transferred (P .05). Women smoking marijuana more than 10 times in their lifetime had infants 17% (P = .01) smaller at birth. If men smoked marijuana 11 to 90 times in their lifetime, there was a 15% decrease in infant birth weight (P = .03); if this increased to more than 90 times, there was a 23% decrease (P = .01) . Timing also played a role. Women smoking marijuana 1 year before IVF/GIFT had 25% fewer oocytes retrieved (P = .03), whereas couples had 28% (P = .04) fewer oocytes fertilized. Women and men who smoked in the past 15 years, had 12% (P = .04) and 16% (P = .03) smaller infants, respectively. Conclusion: Both timing and amount of marijuana use negatively affected IVF/GIFT.