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Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats

Asian pacific Journal of Reproduction 2021年第4期10卷 168-175页

作者： Sevil Kiremitli Tunay Kiremitli Umit Nayki Nesrin Yilmaz Can Turkler Kemal Dinc Renad Mammadov Gulce Naz Yazici mine Gulaboglu Nihal Cetin Erzincan Binali Yildirim University Faculty of Medicine Department of Obstetrics and GynaecologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of PharmacologyErzincanTurkey Erzincan Binali Yildirim University Faculty of Medicine Department of Histology and EmbryologyErzincanTurkey Ataturk University Faculty of Pharmacy Department of BiochemistryErzurumTurkey Selcuk University Faculty of Medicine Department of PharmacologyKonyaTurkey

Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in ***:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion *** ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion *** and histopathologic examinations were performed on the extracted ***:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion ***,these values were reversed in the taxifolin+ovarian ischemia reperfusion ***,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion ***:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury.

关键词： Antioxidants Ischemia-reperfusion Ovarian damage Rat Taxifolin Oxidative stress Ovarian torsion

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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

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World Journal of Gastroenterology 2011年第16期17卷 2109-2112页

作者： Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan Department of General Surgery Yuzuncu Y1l University Medical Faculty Department of Biochemistry Cerrahpasa Medical Faculty University of Istanbul Department of Gastroenterology Medical FacultyUniversity of Yüzüncü Y1l Department of Endocrinology Okmeydani Education and Research Hospital Department of Internal Medicine Medical FacultyUniversity of Yüzüncü Y1l Department of Biostatistics Istanbul Medical FacultyUniversity of Istanbul II.General Surgery Haseki Education and Research Hospital

AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric ***:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this *** serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent ***:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological *** were not significantly associated with age,gender,tumor location,or histological ***:Increased MMP-1 and TIMP-1 were associated with gastric *** these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.

关键词： Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1

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Interventional Cardiology Management of a Cardiogenic Shock Induced by Takotsubo Cardiomyopathy at the Hospital Center of Montlucon: A Case Report

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World Journal of Cardiovascular Diseases 2021年第1期11卷 45-51页

作者： Sylvain Chanseaume mazou Ngou Temgoua Lise Camus Enver Hilic Thierry Comte Aline Billebault Nouhoun Diallo Assi Sami Gislain Beyina Joel Noutakdie Tochie Cardiology Unit Hospital Center of Montlucon Montlucon France Department of Internal Medicine and Specialties Faculty of Medicine and Biomedical Sciences Yaoundé Cameroon Intensive Care Unit Hospital Center of Montlucon Montlucon France Department of Anesthesiology and Critical Care Medicine Faculty of Medicine and Biomedical Sciences Yaoundé Cameroon

Background: Takotsubo cardiomyopathy is frequently considered as a benign disorder. We present an atypical form with cardiogenic shock that was managed by interventional cardiology measures. Case presentation: A 58 years old female patient with a past history of hypertension, obesity and multiple sclerosis was admitted at the Hospital Center of Montlucon for septic shock of urinary origin. During hospitalization in intensive care unit, the patient presented a markedly increasing of troponin levels with a diffused ST-segment elevation. Transthoracic Echocardiography showed an altered left ventricular ejection fraction at 35% with hypokinesia of apex and lateral ventricular segments in conjunction with compensatory hyperkinesis of the base;these findings were strongly suggestive of a diagnosis of Takotsubo cardiomyopathy. Despite concomitant anemia, renal failure and sepsis, all adequately treated with complete remission, the patient developed frequent episodes of ventricular tachycardia that prompted an emergency coronarography. During this procedure, the patient presented a cardiogenic shock and bradyasystole that were successfully managed by intra-aortic balloon pumping and temporary transvenous pacing. Finally, there were no coronary lesions and ventriculography confirmed a Takotsubo cardiomyopathy. Given the unstable hemodynamic status of this patient, she was addressed to the University Teaching Hospital of Clermont-Ferrand for more spec

关键词： Interventional Cardiology Management Cardiogenic Shock Takotsubo Cardiomyopathy

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Effect of in vitro interferon-beta administration on hepatitis C virus in peripheral blood mononuclear cells as a predictive marker of clinical response to interferon treatment for chronic hepatitis C

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World Journal of Gastroenterology 2004年第5期10卷 733-736页

作者： Kaori Mochizuki Tatehiro Kagawa Shinji Takashimizu Kazuya Kawazoe Sei-Ichiro Kojima Naruhiko Nagata Atsushi Nakano Yasuhiro Nishizaki Koichi Shiraishi Masaru Itakura Norihito Watanabe Tetsuya mine Shohei Matsuzaki Department of Internal Medicine Division of GastroenterologyTokai University School of MedicineBohseidaiIsehara 259-1193Japan

AIM:To test whether in vitro incubation of peripheral blood mononuclear cells (PBMC) with interferon (IFN) could efficiently decrease hepatitis C virus-RNA (HCV-RNA) amount and to analyze whether this effect was associated with clinical response to ***:Twenty-seven patients with histologically proven chronic hepatitis C were given intravenous administration of 6 million units (MU) IFN-β daily for 6 weeks followed by three times weekly for 20 weeks. PBMC collected before IFN therapy were incubated with IFN-β and HCV-RNA in PMBC was semi-quantitatively ***: Twenty-five patients completed IFN *** patients (32%) had sustained loss of serum HCV-RNA with normal serum ALT levels after IFN therapy (complete responders).HCV-RNA in PBMC was detected in all patients,whereas it was not detected in PBMC from healthy *** vitro administration of IFN-β decreased the amount of HCV-RNA in PMBC in 18 patients (72%). Eight of these patients obtained complete response. On the other hand,none of the patients whose HCV-RNA in PBMC did not decrease by IFN-β was complete responders. Multiple logistic regression analysis revealed that the decrease of HCV-RNA amount in PBMC by IFN-β was the only independent predictor for complete response (P<0.05).CONCLUSION:The effect of in vitro IFN-β on HCV in PBMC reflects clinical response and would be taken into account as a predictive marker of IFN therapy for chronic hepatitis C.

关键词： Adult Antiviral Agents dosage Drug Resistance, Viral Female Hepacivirus Hepatitis C, Chronic Humans In Vitro Interferon-beta Leukocytes, Mononuclear Male Middle Aged Predictive Value of Tests RNA, Viral

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Anesthesia Management in Case of Carotid Anatomic Variant during Carotid Endarterectomy under General Anesthesia

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Open Journal of Anesthesiology 2012年第2期2卷 15-17页

作者： David Faraoni Benjamin mine Giulia Apicella Alexandre Joosten Department of Anesthesiology Centre Hospitalier Universitaire Brugmann Université Libre de Bruxelles Brussels Belgium Department of Anesthesiology Erasme University Hospital Université Libre de Bruxelles Brussels Belgium. Department of Diagnostic & Interventional Neuroradiology Erasme University Hospital Université Libre de Bruxelles Brussels Bel-gium Department of Vascular Surgery Erasme University Hospital Brussels Belgium

Carotid endarterectomy is an established treatment in the prevention of transient ischemic attack or stroke. Cerebral embolism, thrombosis or hypo-perfusion will lead to a major risk of perioperative thrombotic events. In this case, we report an interesting anesthesia approach for aortic arch anatomic variant management and monitoring.

关键词： Neuromonitoring Vascular Surgery Carotid Surgery Stroke Bispectral Index

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整体规划,科学发展,推进煤炭生产规模化、现代化

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中国煤炭 2009年第9期35卷 23-25页

作者： Datong Coal mine Group Co Ltd 大同煤矿集团有限责任公司

介绍了大同煤矿集团大型矿井的建设情况,重点阐述了同煤大唐塔山煤矿整体规划、科技创新,注重环保和循环发展的建设模式。

关键词：整体规划科技创新大型煤矿建设大同煤矿集团

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GEOLOGICAL FEATURES AND ORE- FORMING MODEL OF THE SHIZHUYUAN W-SN-MO-BI ORE DEPOSIT,HUNAN PROVINCE,CHINA

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Geotectonica et Metallogenia 2000年第1期24卷 75-78页

作者： YIN Bing (The Shizhuyuan mine,Chenzhou 423037,Hunan,China)

The Shizhuyuan W,Sn,Mo and Bi polymetallic ore deposit is one of the world famous superlarge ore *** paper briefly introduced the geological setting and features of the ore ***,an ore－ forming model was put forward a... 详细信息

关键词： Shizhuyuan polymetallic ore deposit geological feature ore- forming model

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不同大豆分离蛋白凝胶的流变学性质

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中国粮油学报 2003年第6期18卷 43-48页

作者：华欲飞 Steve W.Cui Qi Wang Yoshinori mine 江南大学食品学院无锡210036

本文比较研究了三种不同大豆分离蛋白 (分别为SG、ADM和ON)的凝胶性能。三种大豆分离蛋白的 7S/ 11S比率和变性热焓类似 ,但表面疏水性和混浊度却明显不同。通过小变形振荡流变分析研究了三种大豆分离蛋白的热凝胶性能。在去离子水中 ,S... 详细信息

本文比较研究了三种不同大豆分离蛋白 (分别为SG、ADM和ON)的凝胶性能。三种大豆分离蛋白的 7S/ 11S比率和变性热焓类似 ,但表面疏水性和混浊度却明显不同。通过小变形振荡流变分析研究了三种大豆分离蛋白的热凝胶性能。在去离子水中 ,SG和ADM的凝胶浓度均是 90mg/ml,且两者的凝胶强度接近 ;ON的凝胶浓度是 110mg/ml。在 1.0mol/LNaCl溶液中 ,ADM的凝胶强度高于SG。在NaSCN存在的情况下 ,ON的凝胶强度明显增加。尽管N -乙基马来酰亚胺 (NEM )能够封闭巯基 ,但该试剂可增强三种大豆分离蛋白的凝胶强度。结果显示SG和ADM之间的凝胶性能的差别主要是由于表面疏水性不同。

关键词：大豆大豆分离蛋白流变学性质凝胶性能小变形振荡流变分析

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鸡消化道的重要天然免疫效应分子-抗菌肽

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中国预防兽医学报 2008年第12期30卷 987-991页

作者：黎观红游金明瞿明仁 mine Yoshinori 江西农业大学动物科技学院江西南昌330045 Ontario Agricultural College University of Guelph Guelph Ontario N1G 2W1 Canada

抗菌肽广泛分布于动植物及昆虫体内，是天然免疫（非特异性免疫）防御系统的重要组成部分。抗菌肽不仅有广谱抗细菌能力，还可以抗真菌、被膜病毒等多种微生物及抗寄生虫，而且对一些恶性肿瘤细胞和艾滋病毒等也有杀伤作用。动物内源性... 详细信息

抗菌肽广泛分布于动植物及昆虫体内，是天然免疫（非特异性免疫）防御系统的重要组成部分。抗菌肽不仅有广谱抗细菌能力，还可以抗真菌、被膜病毒等多种微生物及抗寄生虫，而且对一些恶性肿瘤细胞和艾滋病毒等也有杀伤作用。动物内源性抗菌肽是基因编码的阳离子多肽，在机体组织中分布广泛，尤其是那些与微生物密切接触的上皮组织如消化道、呼吸道、生殖道粘膜上皮和皮肤，抗菌肽在机体局部抗感染与免疫方面发挥着重要作用。

关键词：非特异性免疫抗菌肽消化道效应分子天然恶性肿瘤细胞艾滋病毒机体组织

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Briefly on Treating Sental Dementia by Acupuncture

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中国针灸 1995年第S2期15卷 339-340页

作者： Zhao Bingmin Zhao Hui (The First Worker’s Hospilal of Da Tong mine Office,Da Tong 037003,Shan Xi Province)

ＢｒｉｅｆｌｙｏｎＴｒｅａｔｉｎｇＳｅｎｔａｌＤｅｍｅｎｔｉａｂｙＡｃｕｐｕｎｃｔｕｒｅ￥ＺｈａｏＢｉｎｇｍｉｎ；ＺｈａｏＨｕｉ（ＴｈｅＦｉｒｓｔＷｏｒｋｅｒ＇ｓＨｏｓｐｉｌａｌｏｆＤａＴｏｎｇＭｉｎｅＯｆｆｉｃｅ，... 详细信息

ＢｒｉｅｆｌｙｏｎＴｒｅａｔｉｎｇＳｅｎｔａｌＤｅｍｅｎｔｉａｂｙＡｃｕｐｕｎｃｔｕｒｅ￥ＺｈａｏＢｉｎｇｍｉｎ；ＺｈａｏＨｕｉ（ＴｈｅＦｉｒｓｔＷｏｒｋｅｒ＇ｓＨｏｓｐｉｌａｌｏｆＤａＴｏｎｇＭｉｎｅＯｆｆｉｃｅ，ＤａＴｏｎｇ０３７００３，Ｓｈａｎ...

关键词： Acupuncture

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