Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer

作     者：Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan 

作者机构：Department of General SurgeryYuzuncu Y1l University Medical Faculty Department of BiochemistryCerrahpasa Medical Faculty University of Istanbul Department of GastroenterologyMedical FacultyUniversity of Yüzüncü Y1l Department of EndocrinologyOkmeydani Education and Research Hospital Department of Internal MedicineMedical FacultyUniversity of Yüzüncü Y1l Department of BiostatisticsIstanbul Medical FacultyUniversity of Istanbul II.General SurgeryHaseki Education and Research Hospital 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第16期

页      面：2109-2112页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1 

摘      要：AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric ***:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this *** serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent ***:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological *** were not significantly associated with age,gender,tumor location,or histological ***:Increased MMP-1 and TIMP-1 were associated with gastric *** these markers are not good markers for diagnosis,these markers show in advanced gastric cancer.