Taxifolin attenuates ischemia-reperfusion induced oxidative ovarian damage in rats
作者机构：Erzincan Binali Yildirim University Faculty of MedicineDepartment of Obstetrics and GynaecologyErzincanTurkey Erzincan Binali Yildirim University Faculty of MedicineDepartment of PharmacologyErzincanTurkey Erzincan Binali Yildirim University Faculty of MedicineDepartment of Histology and EmbryologyErzincanTurkey Ataturk University Faculty of PharmacyDepartment of BiochemistryErzurumTurkey Selcuk University Faculty of MedicineDepartment of PharmacologyKonyaTurkey
出 版 物：《Asian pacific Journal of Reproduction》 (亚太生殖杂志（英文版）)
年 卷 期：2021年第10卷第4期
页 面：168-175页
基 金：Erzincan Binali Yildirim University Faculty of Medicine Professor Halis Suleyman
主 题：Antioxidants Ischemia-reperfusion Ovarian damage Rat Taxifolin Oxidative stress Ovarian torsion
摘 要：Objective:To investigate preventive effects of taxifolin on ischemia-reperfusion induced oxidative ovarian damage in ***:A total of 18 female Wistar albino rats were randomly and equally divided into three groups:the sham group,the ovarian ischemia reperfusion group,and the 50 mg/kg taxifolin+ovarian ischemia reperfusion *** ovarian ischemia reperfusion and taxifolin+ovarian ischemia reperfusion groups were exposed to ischemia for 2 h and then followed by two-hour reperfusion *** and histopathologic examinations were performed on the extracted ***:Levels of malondialdehyde and cyclooxygenase-2 were increased,while reduced-glutathione and cyclooxygenase-1 were decreased in the ovarian ischemia reperfusion ***,these values were reversed in the taxifolin+ovarian ischemia reperfusion ***,the number of primordial and developing follicules decreased in the ovarian ischemia reperfusion group,while they were within normal range in the taxifolin+ovarian ischemia reperfusion ***:Ischemia followed by reperfusion leads to oxidative stress-related ovarian injury,and taxifolin may be useful for protecting ovarian tissue from such injury.
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