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Cellular & Molecular Immunology 2021年第12期18卷 2673-2675页

作者： Prerna Arora Cheila Rocha Amy Kempf Inga Nehlmeier Luise Graichen martin S.Winkler martin Lier Sebastian Schulz Hans-martin jäck Anne Cossmann Metodi V.Stankov Georg M.N.Behrens Stefan Pöhlmann Markus Hoffmann Infection Biology Unit German Primate CenterKellnerweg 437077GöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenWilhelmsplatz 137073GöttingenGermany Department of Anesthesiology University of Göttingen Medical CenterGeorg-August University of GöttingenRobert-Koch-Straße 4037075GöttingenGermany Division of Molecular Immunology Department of Internal Medicine 3Friedrich-Alexander University of Erlangen-NürnbergGlückstraße 691054ErlangenGermany Department for Rheumatology and Immunology Hannover Medical SchoolCarl-Neuberg-Straße 130625HannoverGermany

The COVID-19 pandemic,caused by SARS-CoV-2,continues to rage in many countries,straining health systems and *** protect against severe disease and death and are considered central to ending the ***-19 vaccines(and SARS-CoV-2 infection)elicit antibodies that are directed against the viral spike(S)protein and neutralize the ***,the emergence of SARS-CoV-2 variants with S protein mutations that confer resistance to neutralization might compromise vaccine efficacy[1].

关键词： antibodies vaccine death

Impaired immune reaction and increased lactate and C-reactive protein for early prediction of severe morbidity and pancreatic fistula after pancreatoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 58-67页

作者： Mario Rodriguez-Lopez Francisco j.Tejero-Pintor martin Bailon-Cuadrado Asterio Barrera-Rebollo Baltasar Perez-Saborido David Pacheco-Sanchez General and Digestive Surgery Department Rio-Hortega University Hospital

Background: Prediction of complications after pancreatoduodenectomy (PD) remains of interest. Blood parameters and biomarkers during rst and second postoperative days (POD1, POD2) may be early indi- cators of complications. Methods: This case-control study included 50 patients. Baseline, POD1 and POD2 values of leukocytes, neutrophils, lymphocytes, platelets, hemoglobin, C-reactive protein (CRP), procalcitonin and arterial lactate were compared between individuals presenting Clavien ≥ III morbidity, pancreatic stula (PF) or clinically relevant PF (CRPF) and those without these morbidities. Common variables reaching signi cance were further analyzed in order to calculate a predictive score. Results: Severe morbidity, PF and CRPF rates were 28.0%, 26.0% and 14.0%, respectively. Patients with severe morbidity had lower leukocytes on POD2 (P=0.04). Patients with PF presented higher CRP on POD2 (P=0.001), higher lactate on POD1 (P=0.007) and POD2 (P=0.008), and lower lymphocytes on POD1 (P=0.007) and POD2 (P=0.008). Patients with CRPF had lower leukocytes and neutrophils on POD1 (P =0.048, P =0.038), lower lymphocytes on POD1 (P =0.001) and POD2 (P =0.003), and higher CRP on POD2 (P =0.001). Baseline parameters and procalcitonin obtained no statistical associations. Score was de ned according to lymphocytes on POD1 < 650/μL and CRP on POD2 ≥ 250 mg/L allocating patients in 3 risk categories. PF and CRPF rates were statistically higher as risk category increased (P<0.001). Receiver operating characteristic curves and Hosmer Lemeshow tests showed a good accuracy. Conclusions: Impaired immunological reaction during early postoperative period (lower leukocytes and, particularly, lymphocytes) in response to surgical aggression would favor complications after PD. Likewise, acidosis (higher arterial lactate) could behave as risk factor of PF. An elevated CRP on POD2 is also an early biomarker of PF. Our novel score based on postoperative lymphocyte count and CRP seems reliable

关键词： Pancreatoduodenectomy Morbidity Pancreatic fistula Biomarker Prediction Score

Intraspecific temporal resource partitioning at white-tailed deer feeding sites

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Current Zoology 2019年第2期65卷 139-146页

作者： David B. STONE james A. martin Bradley S. COHEN Thomas j. PREBYL Charlie KILLMASTER Karl V. MILLER Warnell School of Forestry and Natural Resources University of Georgia Athens GA USA Savannah River Ecology Lab University of Georgia Aiken SC USA Department of Biology Tennessee Technological University Cookeville TN USA Georgia Department of Natural Resources Atlanta GA USA

Individuals may reduce competition by temporally partitioning their use of a shared resource. Behavioral differences between sexes in ungulates may encourage segregation as individuals attempt to avoid antagonistic interactions. However, dominant sex and age groups may reduce subordinates' access to food resources, regardless of the subordinate's sex. We hypothesized that white-tailed deer Odocoileus Virginian us temporally segregated at supplemental feedi ng sites based on social rank (subordinate: yearling males and adult females;dominant: adult males) and that segregation was affected by phase of the breeding season and diel cycle. If deer temporally segregate according to social rank, we predicted that the resulting activity patterns would manifest in one social class being relatively more susceptible to hunter-induced mortality. We used a multistate modeling approach to quantify temporal segregation and calculated the probability that a feeding site was in a particular state during diurnal and nocturnal hours for each of the 3 phases of the breeding season. We determined that transition probabilities differed by season and diel cycle and dominant and subordinate social classes clearly avoided each other, with <1% co-occurrenee at feedi ng sites. During the pre-breedi ng seas on, the probability of a subordi nate being present during diurnal hours was *** more likely than a dominant being present, but did not differ during nocturnal hours. There was no difference for dominants and subordinates during diurnal or no cturnal hours during the breedi ng season .In the post-breedi ng season, subordi nates were 1.7x more likely to occur at the feeding site than a dominant during diurnal hours but they did not differ during nocturnal hours. Our results indicate that dominance status influences temporal segregation at feeding sites and is affected by the phase of the breeding season. Therefore, the resulti ng activity patterns may in crease subordi nates' risk to human

关键词： competition multistate modeling predation risk supplemental feeding sites intraspecific temporal resource partitioning white-tailed deer

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

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World journal of Gastroenterology 2019年第26期25卷 3344-3358页

作者： Timothy N Archampong Richard H Asmah Cathy j Richards Vicki j martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho Department of Medicine and Therapeutics School of Medicine and DentistryUniversity of GhanaAccra Box 4236Ghana Department of Genetics and Genome Biology University of LeicesterLeicester LE1 7RHUnited Kingdom Department of Medical Laboratory Sciences School of Biomedical and Allied Health SciencesUniversity of GhanaAccra Box 4236Ghana Department of Histopathology Leicester Royal InfirmaryLeicester LE1 5WWUnited Kingdom Department of Pathology Maputo Central HospitalMaputo POBox 1164Mozambique Department of Pathology Medical Faculty of the University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology at the University of Porto(Ipatimup) Porto 4200-465Portugal Instituto de Investigacao e Inovacao em Saude(i3S) University of PortoPorto 4200-465Portugal Department of Pathology Faculty of MedicineEduardo Mondlane UniversityMaputo POBox 257Mozambique

Gastroduodenal disease(GDD)was initially thought to be uncommon in *** others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the *** the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of *** risk factors for gastric cancer(GCA)include Helicobater pylori(***),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are ***,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol *** these,*** is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal ***,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,*** there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic *** Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical ***,there are differences in PUD within-country despite universally endemic *** *** is not uncommon in *** of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western *** additional intriguing observation is a recent,ongoing decline in PUD in some African countries where *** infection is still *** possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter *** prevalence

关键词： Gastroduodenal Peptic ulcer Gastric cancer Africa Pre-malignant Atrophy Intestinal metaplasia Duodenal ulcer Gastric ulcer

新的基于mass-assignment的模糊CMAC神经网络及其学习收敛性(英文)

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软件学报 2001年第6期12卷 816-821页

作者：王士同 j.F.Baldwin T.P.martin2 华东船舶工程学院计算机系江苏镇江212003 英国Bristol大学高级计算研究中心

基于 ***等人提出的 mass- assignment理论 ,提出了新的基于 mass- assignment的模糊 CMAC神经网络 ,接着研究了其学习规则 .理论研究结果揭示出 ,此新模糊 CMAC是一个全局逼近器 ,并且具有学习收敛性 .故此新模糊 CMAC有非常重要的应... 详细信息

基于 ***等人提出的 mass- assignment理论 ,提出了新的基于 mass- assignment的模糊 CMAC神经网络 ,接着研究了其学习规则 .理论研究结果揭示出 ,此新模糊 CMAC是一个全局逼近器 ,并且具有学习收敛性 .故此新模糊 CMAC有非常重要的应用潜力 .

关键词：模糊CMAC 学习规则 mass-assignment理论学习收敛性神经网络

OPTICAL MEASUREMENT OF PHOTOSENSITIZER CONCENTRATION IN VIVO

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journal of Innovative Optical Health Sciences 2011年第2期4卷 97-111页

作者： martin R.AUSTWICK jOSEPHINE H.WOODHAMS VADZIM CHALAU CHARLES A.MOSSE CAROLINE ELIOT LAURENCE LOVAT ALEXANDER j.MACROBERT IRVING j.BIGIO STEPHEN G.BOWN National Medical Laser Centre Charles Bell House 67-73 Riding House Street University College London London W1W 7EJUK Boston University BME44 Cummington Street BostonMA 02215USA

Most techniques for measuring tissue concentrations of drugs are invasive,time-consuming,and often require the removal of tissue or *** pharmacokinetics(OP)is a minimally invasive alternative giving an immediate *** of white light are directed at the tissue of interest using afiber optic *** light is detected by a secondfiber immediately adjacent to thefirst in the same probe(separation 1.7 mm).Using the photosensitizer disulfonated aluminium phthalocyanine(AlS_(2)Pc),OP measurements were made in phantoms and on the mouth,stomach,colon,skin,and liver of normal rats 1 and 24 h after intravenous AlS_(2)Pc ***_(2)Pc concentration was determined by calculating the area under the curve(AUC)in the spectral region around the peak drug absorption or measuring the height of the *** baseline interpolation removed the need for pre-drug,control optical *** measurements correlated well with values from alkali chemical extraction(CE)of the corresponding tissues,(R^(2)0.87=0.97).OP measurements in the mouth also correlated with CE of less accessible internal organs(R^(2)0.77-0.88).In phantoms,the lowest detectable concentration was 0.1μg/*** vivo,results were limited by the lower accuracy in the CE measurements but were almost certainly *** incidentalfinding was a 12-15nm red shifted component in the spectra observed 1 h after drug administration,suggesting partitioning of the drug in different microenvironment compartments,which could prove to be of considerable interest in future *** conclusion,OP shows promise for real-time measurement of concentrations of drugs with suitable absorption peaks.

关键词： Optical pharmacokinetics chemometrics photodynamic therapy noninvasive measurement

什么是《最终用户》?标识信息系统用户间的多种关系

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计算机工程与应用 1991年第Z1期 235-240页

作者： C、j、martin 李伟国家教委信息中心

计算机用户与信息系统和信息间的关系是很微妙的,而且在组织机构中可能存在着许多种不同类型的关系。以前的“用户“和“最终用户”的定义强调的是直接的交互式的计算机应用,没有包括间接关系,而且也没有考虑交互的原因,因而需要一个新... 详细信息

计算机用户与信息系统和信息间的关系是很微妙的,而且在组织机构中可能存在着许多种不同类型的关系。以前的“用户“和“最终用户”的定义强调的是直接的交互式的计算机应用,没有包括间接关系,而且也没有考虑交互的原因,因而需要一个新的定义框架,包含不同方式和目的的IS用户。这篇文章提出了一个两维的分类方法,采用相关性维度和目的维度,以便更准确地标识关系的特性。相关性维度的含义是用户与信息资源是如何紧密相关,目的维度的含义是用户使用信息做些什么。新的分类方法将有助于弄清楚计算机用户,系统与IS支持人员之间的微妙的不断变化的关系。

关键词：最终用户定义计算机消费者相关性维度

Spin Transport in Multi Wall Carbon Nanotubes with Co Electrodes

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Chinese Physics Letters 2006年第10期23卷 2852-2855页

作者：王天兴魏红祥韩秀峰 R.M.Langford martin Thornton M.A.Bari j.M.D.Coey State Key Laboratory of Magnetism Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100080 Department of Physics Trinity College Dublin 2 Ireland

The magnetic field dependent transport behaviour of Co contacted multi-wall nanotubes is investigated. A sample with three Co electrodes has been measured by two-channel method with an in-plane magnetic field. When the in-plane magnetic field is perpendicular to the tube, high positive magnetoresistance up to 30% is obtained at low temperature from 3 K to 25K and with field parallel to the tube, negative magnetoresistance up to 15% is observed only from the high resistance junction. The detailed positive and negative magnetoresistance behaviour also changes with temperature.

关键词： COHERENT TRANSPORT MAGNETORESISTANCE RESISTANCE

Adaptive optics in laser processing

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Light(Science & Applications) 2019年第1期8卷 140-155页

作者： Patrick S.Salter martin j.Booth Department of Engineering Science University of OxfordParks RoadOxford OX13PJUK

Adaptive optics are becoming a valuable tool for laser processing,providing enhanced functionality and flexibility for a range of *** a single adaptive element,it is possible to correct for aberrations introduced when focusing inside the workpiece,tailor the focal intensity distribution for the particular fabrication task and/or provide parallelisation to reduce processing *** is particularly promising for applications using ultrafast lasers for threedimensional *** review recent developments in adaptive laser processing,including methods and applications,before discussing prospects for the future.

关键词： laser optics workpiece

Integrating MEMS and ICs

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Microsystems & Nanoengineering 2015年第1期1卷 165-180页

作者： Andreas C.Fischer Fredrik Forsberg martin Lapisa Simon j.Bleiker Göran Stemme Niclas Roxhed Frank Niklaus Department of Micro and Nanosystems School of Electrical EngineeringKTH Royal Institute of TechnologySE-10044 StockholmSweden

The majority of microelectromechanical system(MEMS)devices must be combined with integrated circuits(ICs)for operation in larger electronic *** MEMS transducers sense or control physical,optical or chemical quantities,ICs typically provide functionalities related to the signals of these transducers,such as analog-to-digital conversion,amplification,filtering and information processing as well as communication between the MEMS transducer and the outside ***,the vast majority of commercial MEMS products,such as accelerometers,gyroscopes and micro-mirror arrays,are integrated and packaged together with *** are a variety of possible methods of integrating and packaging MEMS and IC components,and the technology of choice strongly depends on the device,the field of application and the commercial *** this review paper,traditional as well as innovative and emerging approaches to MEMS and IC integration are *** include approaches based on the hybrid integration of multiple chips(multi-chip solutions)as well as system-on-chip solutions based on wafer-level monolithic integration and heterogeneous integration *** are important technological building blocks for the‘More-Than-Moore’paradigm described in the International Technology Roadmap for *** this paper,the various approaches are categorized in a coherent manner,their merits are discussed,and suitable application areas and implementations are critically *** implications of the different MEMS and IC integration approaches for packaging,testing and final system costs are reviewed.

关键词： cofabrication platforms integrated circuits(ICs) microelectromechanical system(MEMS) More-Than-Moore multichip modules(MCMs) system-in-package(SiP) system-on-chip(SoC) three-dimensional(3D)heterogeneous integration