Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

作     者：Timothy N Archampong Richard H Asmah Cathy J Richards Vicki J Martin Christopher D Bayliss Edília Botao Leonor David Sandra Beleza Carla Carrilho 

作者机构：Department of Medicine and TherapeuticsSchool of Medicine and DentistryUniversity of GhanaAccra Box 4236Ghana Department of Genetics and Genome BiologyUniversity of LeicesterLeicester LE1 7RHUnited Kingdom Department of Medical Laboratory SciencesSchool of Biomedical and Allied Health SciencesUniversity of GhanaAccra Box 4236Ghana Department of HistopathologyLeicester Royal InfirmaryLeicester LE1 5WWUnited Kingdom Department of PathologyMaputo Central HospitalMaputo POBox 1164Mozambique Department of PathologyMedical Faculty of the University of PortoPorto 4200-465Portugal Institute of Molecular Pathology and Immunology at the University of Porto(Ipatimup)Porto 4200-465Portugal Instituto de Investigacao e Inovacao em Saude(i3S)University of PortoPorto 4200-465Portugal Department of PathologyFaculty of MedicineEduardo Mondlane UniversityMaputo POBox 257Mozambique 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2019年第25卷第26期

页      面：3344-3358页

核心收录：

学科分类：10[医学] 

基　　金：University of Ghana Research fund URF/5/ILG-003/2011-2012 to Timothy N Archampong by the Medical Research Council UK with grant MR/M01987X/1 to Sandra Beleza 

主　　题：Gastroduodenal Peptic ulcer Gastric cancer Africa Pre-malignant Atrophy Intestinal metaplasia Duodenal ulcer Gastric ulcer 

摘      要：Gastroduodenal disease(GDD)was initially thought to be uncommon in *** others,lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the *** the increasing availability of flexible upper gastro-intestinal endoscopy,it has now become apparent that GDD,especially peptic ulcer disease(PUD),is prevalent across the continent of *** risk factors for gastric cancer(GCA)include Helicobater pylori(***),diet,Epstein-Barr virus infection and industrial chemical exposure,while those for PUD are ***,non-steroidal antiinflammatory drug(NSAID)-use,smoking and alcohol *** these,*** is generally accepted to be causally related to the development of atrophic gastritis(AG),intestinal metaplasia(IM),PUD and distal ***,we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy,and complement the analysis with new data obtained on premalignant gastric his-topathological lesions in Accra,Ghana which was compared with previous data from Maputo,*** there is a general lack of structured cohort studies in Africa,we also considered endoscopy-based hospital or tertiary centre studies of symptomatic *** Africa,there is considerable heterogeneity in the prevalence of PUD with no clear geographical ***,there are differences in PUD within-country despite universally endemic *** *** is not uncommon in *** of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western *** additional intriguing observation is a recent,ongoing decline in PUD in some African countries where *** infection is still *** possible reason for the high,sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter *** prevalence