OPTICAL MEASUREMENT OF PHOTOSENSITIZER CONCENTRATION IN VIVO
药物浓度在体内光学测量作者机构：National Medical Laser Centre Charles Bell House67-73 Riding House Street University College London London W1W 7EJUK Boston UniversityBME44 Cummington Street BostonMA 02215USA
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2011年第4卷第2期
页 面：97-111页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：We thank Dr Stephen Chad Kanick and Dr Robert Parker of the University of Pittsburgh for discussions regarding analytical approaches.The US Department of Health and Human Services National Institutes of Health(NIH)are gratefully acknowledged for their funding of this project(project No.5 U54 CA 104677-05) which was part of the NTROI programme(Network for Translational Research on Optical Imaging).This work was undertaken at UCLH/UCL who received a proportion of funding from the Department of Health's NIHR Biomedical Research Centres funding scheme.The views expressed in this publication are those of the authors and not necessarily those of the Department of Health.This work was supported by the Experimental Cancer Medicine Centre University College London
主 题：Optical pharmacokinetics chemometrics photodynamic therapy noninvasive measurement
摘 要：Most techniques for measuring tissue concentrations of drugs are invasive,time-consuming,and often require the removal of tissue or *** pharmacokinetics(OP)is a minimally invasive alternative giving an immediate *** of white light are directed at the tissue of interest using afiber optic *** light is detected by a secondfiber immediately adjacent to thefirst in the same probe(separation 1.7 mm).Using the photosensitizer disulfonated aluminium phthalocyanine(AlS_(2)Pc),OP measurements were made in phantoms and on the mouth,stomach,colon,skin,and liver of normal rats 1 and 24 h after intravenous AlS_(2)Pc ***_(2)Pc concentration was determined by calculating the area under the curve(AUC)in the spectral region around the peak drug absorption or measuring the height of the *** baseline interpolation removed the need for pre-drug,control optical *** measurements correlated well with values from alkali chemical extraction(CE)of the corresponding tissues,(R^(2)0.87=0.97).OP measurements in the mouth also correlated with CE of less accessible internal organs(R^(2)0.77-0.88).In phantoms,the lowest detectable concentration was 0.1μg/*** vivo,results were limited by the lower accuracy in the CE measurements but were almost certainly *** incidentalfinding was a 12-15nm red shifted component in the spectra observed 1 h after drug administration,suggesting partitioning of the drug in different microenvironment compartments,which could prove to be of considerable interest in future *** conclusion,OP shows promise for real-time measurement of concentrations of drugs with suitable absorption peaks.
维普期刊数据库