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Renal ablation using magnetic resonance-guided high intensity focused ultrasound: Magnetic resonance imaging and histopathology assessment

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world Journal of Radiology 2016年第3期8卷 298-307页

作者： Maythem Saeed Roland Krug Loi Do Steven w Hetts mark w wilson Department of Radiology and Biomedical Imaging School of Medicine University of California San Francisco

AIM: To use magnetic resonance-guided high intensity focused ultrasound(MRg-HIFU), magnetic resonance imaging(MRI) and histopathology for noninvasively ablating, quantifying and characterizing ablated renal tissue. METHODS: Six anesthetized/mechanically-ventilated pigs underwent single/double renal sonication(n = 24) using a 3T-MRg-HIFU(1.1 MHz frequency and 3000J-4400 J energies). T2-weighted fast spin echo(T2-w), perfusion saturation recovery gradient echo and contrast enhanced(CE) T1-weighted(T1-w) sequences were used for treatment planning, temperature monitoring, lesion visualization, characterization and quantification, respectively. Histopathology was conducted in excised kidneys to quantify and characterize cellular and vascular changes. Paired Student's t-test was used and a P-value was considered statistically ***: Ablated renal parenchyma could not be differentiated from normal parenchyma on T2-w or nonCE T1-w sequences. Ablated renal lesions were visible as hypoenhanced regions on perfusion and CE T1-w MRI sequences, suggesting perfusion deficits and necrosis. Volumes of ablated parenchyma on CE T1-w images invivo(0.12-0.36 cm3 for single sonication 3000 J, 0.50-0.84 cm3, for double 3000 J, 0.75-0.78 cm3 for single 4400 J and 0.12-2.65 cm3 for double 4400J) and at postmortem(0.23-0.52 cm3, 0.25-0.82 cm3, 0.45-0.68 cm3 and 0.29-1.80 cm3, respectively) were comparable. The ablated volumes on 3000 J and 4400 J double sonication were significantly larger than single(P < 0.01), thus, the volume and depth of ablated tissue depends on the applied energy and number of sonication. Macroscopic and microscopic examinations confirmed the locations and presence of coagulation necrosis, vascular damage and interstitial hemorrhage, ***: Contrast enhanced MRI provides assessment of MRg-HIFU renal ablation. Histopathology demonstrated coagulation necrosis, vascular damage and confirmed the volume of damage seen on MRI.

关键词： Magnetic resonance-guided high intensity focused ultrasound Renal ablation Magnetic resonance imaging Microscopy High intensity focused ultrasound

Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies

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world Journal of Cardiology 2014年第11期6卷 1192-1208页

作者： Maythem Saeed Steven w Hetts Robert Jablonowski mark w wilson Department of Radiology and Biomedical Imaging School of Medicine University of California San Francisco San Francisco CA 94107-5705 United States

Myocardial pathologies are major causes of morbidity and mortality worldwide. Early detection of loss of cellular integrity and expansion in extracellular volume(ECV) in myocardium is critical to initiate effective treatment. The three compartments in healthy myocardium are: intravascular(approximately 10% of tissue volume), interstitium(approximately 15%) and intracellular(approximately 75%). Myocardial cells, fibroblasts and vascular endothelial/smooth muscle cells represent intracellular compartment and the main proteins in the interstitium are types Ⅰ/Ⅲ collagens. Microscopic studies have shown that expansion of ECV is an important feature of diffuse physiologic fibrosis(e.g., aging and obesity) and pathologic fibrosis [heart failure, aortic valve disease, hypertrophic cardiomyopathy, myocarditis, dilated cardiomyopathy, amyloidosis, congenital heart disease, aortic stenosis, restrictive cardiomyopathy(hypereosinophilic and idiopathic types), arrythmogenic right ventricular dysplasia and hypertension]. This review addresses recent advances in measuring of ECV in ischemic and non-ischemic myocardial pathologies. Magnetic resonance imaging(MRI) has the ability to characterize tissue proton relaxation times(T1, T2, and T2*). Proton relaxation times reflect the physical and chemical environments of water protons in myocardium. Delayed contrast enhanced-MRI(DE-MRI) and multi-detector computed tomography(DE-MDCT) demonstrated hyper-enhanced infarct, hypo-enhanced microvascular obstruction zone and moderately enhanced peri-infarct zone, but are limited for visualizing diffuse fibrosis and patchy microinfarct despite the increase in ECV. ECV can be measured on equilibrium contrast enhanced MRI/MDCT and MRI longitudinal relaxation time mapping. Equilibrium contrast enhanced MRI/MDCT and MRI T1 mapping is currently used, but at a lower scale, as an alternative to invasive sub-endomyocardial biopsies to eliminate the need for anesthesia, coronary catheterization and possib

关键词： relaxation detecting compartment eliminate myocarditis cardiomyopathy myocardium infarct tomographic intravascular

Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration

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Neural Regeneration Research 2023年第4期18卷 769-772页

作者： Sandeep Satapathy mark R.wilson Blavatnik Institute of Cell Biology Harvard Medical SchoolBostonMAUSA The Broad Institute of MIT and Harvard CambridgeMAUSA Molecular Horizons and The School of Chemistry and Molecular Bioscience University of WollongongNorthfields AvenueWollongongNSWAustralia Illawarra Health and Medical Research Institute Northfields AvenueWollongongNSWAustralia

Protein quality control involves many processes that jointly act to regulate the expression, localization, turnover, and degradation of proteins, and has been highlighted in recent studies as critical to the differentiation of stem cells during regeneration. The roles of constitutively secreted extracellular chaperones in neuronal injury and disease are poorly understood. Extracellular chaperones are multifunctional proteins expressed by many cell types, including those of the nervous system, known to facilitate protein quality control processes. These molecules exert pleiotropic effects and have been implicated as playing important protective roles in a variety of stress conditions, including tissue damage, infections, and local tissue inflammation. This article aims to provide a critical review of what is currently known about the functions of extracellular chaperones in neuronal repair and regeneration and highlight future directions for this important research area. we review what is known of four constitutively secreted extracellular chaperones directly implicated in processes of neuronal damage and repair, including transthyretin, clusterin, α2-macroglobulin, and neuroserpin, and propose that investigation into the effects of these and other extracellular chaperones on neuronal repair and regeneration has the potential to yield valuable new therapies.

关键词： cell viability clusterin extracellular chaperones inflammation neuroserpin protein misfolding transthyretin α2-macroglobulin

Magnetic resonance imaging characterization of circumferential and longitudinal strain under various coronary interventions in swine

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world Journal of Radiology 2013年第12期5卷 472-483页

作者： Mohammed SA Suhail mark w wilson Steven w Hetts Maythem Saeed Department of Radiology and Biomedical Imaging School of Medicine University of California San Francisco School of Medicine University of California San Diego

AIM:To compare the acute changes in circumferential and longitudinal strain after exposing a coronary artery to various interventions in ***:Percutaneous balloon angioplasty catheter was guided to location aid device(LAD)under X-ray fluoroscopy to create different patterns of ischemic ***(n=32)were equally divided into 4 groups:controls,90 min LAD occlusion/reperfusion,LAD microembolization,and combined LAD occlusion/microembolization/*** days after interventions,cine,tagged and viability magnetic resonance imaging(MRI)were acquired to measure and compare left and right circumferential strain,longitudinal strain and myocardial viability,*** were obtained using HARP and semi-automated threshold method and statistically analyzed using unpaired *** and vascular damage was characterized ***:Coronary microemboli caused greater impairment in l left ventricular(LV)circumferential strain and dyssynchrony than LAD occlusion/reperfusion despite the significant difference in the extent of myocardial *** also caused significant decrease in peak systolic strain rate of remote myocardium and LV *** MRI demonstrated the interaction between LV and right ventricular(RV)at 3 d after *** increase in RV free wall longitudinal strain was seen in response to all *** MRI,histochemical staining and microscopy revealed different patterns of myocardial damage and microvascular ***:Cine MRI revealed subtle changes in LV strain caused by various ischemic *** also demonstrated the interaction between the right and left ventricles after coronary *** microemboli with and without acute myocardial infarction(AMI)cause complex myocardial injury and ventricular dysfunction that is not replicated in solely AMI.

关键词： Magnetic resonance imaging Percutaneous coronary interventions Acute myocardial infarct Microembolization Myocardial strain

Dupilumab-associated ulcerative keratitis

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1020-1022页

作者： Matthew M wilson Philipp K Roberts mark Daniell Corneal Service Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia Medical University of Vienna Vienna 1090Austria Department of Surgery(Ophthalmology) University of MelbourneParkvilleVIC 3013Australia Surgical Research Unit Centre for Eye Research Australia(CERA)University of MelbourneMelbourneVIC 3013Australia

Dear Editor,we present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antibody used in the treatment of moderate-to-severe atopic dermatitis, showing efficacy in clinical trials;. Several publications have reported ocular surface complications associated with dupilumab.

关键词： dermatitis clinical keratitis

AHORA: a Spanish language tool to identify acute stroke symptoms

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Stroke & Vascular Neurology 2022年第2期7卷 176-178页

作者： Paul Banerjee Helene Koumans Madison Danielle weech Maricela wilson mark Rivera-Morales Latha Ganti Fire Rescue Polk County FloridaBartowFloridaUSA Department of Emergency Medicine University of Central Florida College of MedicineOrlandoFloridaUSA Osceola Regional Medical Center KissimmeeFloridaUSA Department of Biology and Medicine Brown UniversityProvidenceRhode IslandUSA Department of Biology University of FloridaGainesvilleFloridaUSA Stroke Community Outreach Seton Healthcare FamilyAustinTexasUSA Department of Neurology University of Central Florida College of MedicineOrlandoFloridaUSA

Objective To develop a Spanish language tool for acute stroke *** A Spanish language translation of the Balance-Eyes-Face-Arm-Speech-Time tool was developed within our emergency medical services *** The authors present a new prehospital stroke tool,Andar,Hablar,Ojos,Rostro and Ambos Brazos o Piernas(AHORA)(which means now in Spanish)to help combat the language barrier and reinforce the necessity to call 9-1-1 as soon as any stroke symptoms are *** AHORA is a Spanish language tool that aims to help Spanish-speaking individuals to identify an acute stroke and obtain prompt help.

关键词： And Spanish prompt

Bio-inspired carbon electro-catalysts for the oxygen reduction reaction

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Journal of Energy Chemistry 2016年第2期25卷 226-233页

作者： Kathrin Preuss Vasanth Kumar Kannuchamy Adam Marinovic mark Isaacs Karen wilson Isaac Abrahams Maria-Magdalena Titirici School of Engineering and Materials Science Queen Mary University of London Materials Research Institute Queen Mary University of London European Bioenergy Research Institute Aston University School of Biological and Chemical Sciences Queen Mary University of London

we report the synthesis, characterisation and catalytic performance of two nature-inspired biomassderived electro-catalysts for the oxygen reduction reaction in fuel cells. The catalysts were prepared via pyrolysis of a real food waste（lobster shells） or by mimicking the composition of lobster shells using chitin and CaCO3 particles followed by acid washing. The simplified model of artificial lobster was prepared for better reproducibility. The calcium carbonate in both samples acts as a pore agent, creating increased surface area and pore volume, though considerably higher in artificial lobster samples due to the better homogeneity of the components. Various characterisation techniques revealed the presence of a considerable amount of hydroxyapatite left in the real lobster samples after acid washing and a low content of carbon（23%）, nitrogen and sulphur（〈1%）, limiting the surface area to 23 m^2/g, and consequently resulting in rather poor catalytic activity. However, artificial lobster samples, with a surface area of ≈200 m^2/g and a nitrogen doping of 2%, showed a promising onset potential, very similar to a commercially available platinum catalyst, with better methanol tolerance, though with lower stability in long time testing over 10,000 s.

关键词： Carbonisation Biomass-derived carbons Oxygen reduction reaction Fuel cells Electro-catalysis

Correlation of in vivo tumor response and singlet oxygen luminescence detection in mTHPC-mediated photodynamic therapy

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Journal of Innovative Optical Health Sciences 2015年第1期8卷 106-112页

作者： Brian C.wilson Michael S.Patterson Buhong Li mark T.Jarvi Department of Medical Biophysics University of Toronto/University Health Network Toronto Ontario M5G 1L7Canada Juravinski Cancer Centre and McMaster University Hamilton Ontario L8V 5C2Canada MOE Key Laboratory of OptoElectronic Science and Technology for Medicine Fujian Provincial Key Laboratory for Photonics Technology Fujian Normal University FuzhouFujian 350007P.R.China

Excited-state singlet axygen(^(1)O_(2)),generated during photodynamic therapy(PDT),is believed to be the primary cytotoxic agent with a number of clinically approved *** relative concentration in cells or tissues can be measured directly through its near-infrared(NIR)luminescence emission,which has correlated well with in vitro cell and in triro normal skin treatment ***,its correlation with the response of tumor tiss1e in vito is examined,using the photosensitizer meso-tetralydroxyphenylchlorin(mTHPC)in an animal model comprising luciferase-and green fluorescent protein(GFP)-transduced gliosarcoma grown in a dorsal window *** change in the bioluminescence signal,imaged pre-treatment and at 2,5 and 9 d post treatment,was used as a quantitative measure of the tumor response,which was classified in individual tumors as"non","moderate"and"strong"in order to reduce the variance in the *** the bioluminescence-based response vs the^(1)O_(2)counts demonstrated clear correlation,indicating tha^(1)O_(2)luminescence provides a valid do-simetric technique for PDT in tumor tissue.

关键词： Photodynamice therapy singlet axygen lumninescence dosinetry bioluminescence

Preparation of elastomeric nanocomposites using nanocellulose and recycled alum sludge for flexible dielectric materials

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Journal of Advanced Dielectrics 2023年第1期13卷 57-65页

作者： Dongyang Sun Bernard L.H.Saw Amaka J.Onyianta Bowen wang Callum wilson Dominic O’Rourke Chan H.See Carmen-Mihaela Popescu mark Dorris Islam Shyha Zhilun Lu School of Engineering and Built Environment Edinburgh Napier UniversityEdinburghUK Lee Kong Chian Faculty of Engineering and Science Universiti Tunku Abdul Rahman KajangMalaysia Bristol Composites Institute School of CivilAerospace and Mechanical Engineering University of BristolUniversity WalkBristolBS81TRUK School of Engineering and Materials Science Queen Mary University of LondonLondonUK Petru Poni Institute of Macromolecular Chemistry of the Romanian Academy IasiRomania

Flexible dielectric materials with environmental-friendly,low-cost and high-energy density characteristics are in increasing demand as the world steps into the new Industrial 4.0 *** this work,an elastomeric nanocomposite was developed by incorporating two components:cellulose nanofibrils(CNFs)and recycled alum sludge,as the reinforcement phase and to improve the dielectric properties,in a bio-elastomer *** and alum sludge were produced by processing waste materials that would otherwise be disposed to landfills.A biodegradable elastomer polydimethylsiloxane was used as the matrix and the nanocomposites were processed by casting the materials in Petri *** extraction and heat treatment of alum sludge were conducted and characterized using various techniques including scanning electron microscopy(SEM),thermogravimetric analysis/derivative thermogravimetric(TGA/DTG)and X-ray diffraction(XRD)*** preparing the nanocomposite samples,various amount of alum sludge was added to examine their impact on the mechanical,thermal and electrical *** have shown that it could be a sustainable practice of reusing such wastes in preparing flexible,lightweight and miniature dielectric materials that can be used for energy storage applications.

关键词： Nanocellulose biodegradable sustainable alum sludge nanocomposite flexible dielectric