Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration

作     者：Sandeep Satapathy Mark R.Wilson Sandeep Satapathy;Mark R.Wilson

作者机构：Blavatnik Institute of Cell BiologyHarvard Medical SchoolBostonMAUSA The Broad Institute of MIT and HarvardCambridgeMAUSA Molecular Horizons and The School of Chemistry and Molecular BioscienceUniversity of WollongongNorthfields AvenueWollongongNSWAustralia Illawarra Health and Medical Research InstituteNorthfields AvenueWollongongNSWAustralia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第4期

页      面：769-772页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：cell viability clusterin extracellular chaperones inflammation neuroserpin protein misfolding transthyretin α2-macroglobulin 

摘      要：Protein quality control involves many processes that jointly act to regulate the expression, localization, turnover, and degradation of proteins, and has been highlighted in recent studies as critical to the differentiation of stem cells during regeneration. The roles of constitutively secreted extracellular chaperones in neuronal injury and disease are poorly understood. Extracellular chaperones are multifunctional proteins expressed by many cell types, including those of the nervous system, known to facilitate protein quality control processes. These molecules exert pleiotropic effects and have been implicated as playing important protective roles in a variety of stress conditions, including tissue damage, infections, and local tissue inflammation. This article aims to provide a critical review of what is currently known about the functions of extracellular chaperones in neuronal repair and regeneration and highlight future directions for this important research area. We review what is known of four constitutively secreted extracellular chaperones directly implicated in processes of neuronal damage and repair, including transthyretin, clusterin, α2-macroglobulin, and neuroserpin, and propose that investigation into the effects of these and other extracellular chaperones on neuronal repair and regeneration has the potential to yield valuable new therapies.