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Effect of electronic stimulation at Neiguan(PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia

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Journal of Traditional Chinese Medicine 2015年第5期35卷 577-582页

作者： Wang Wei Li Jiquan meng xiangyu Chen Yiguo College of Acupuncture and Massage Liaoning University of Traditional Chinese Medicine

OBJECTIVE:To investigate the effects of electronic stimulation at acupoints Neiguan(PC 6) and Lieque(LU 7) on the gene expression of the adenosine triphosphate(ATP)-Sensitive potassium channel(KATP:Kir6.1,Kir6.2,SUR2 A,and SUR2B) and protein kinases(PKA,PKG,and PKCβ2) in myocardial cells of rats with myocardial ischemia(Ml) induced by isoproterenol(ISO).METHODS:Rats were randomly divided into a control,model,Neiguan(PC 6),Lieque(LU 7),and non-acupoint *** Ml model was established by injecting rats with ***-acupuncture treatment was given to the acupuncture groups,once a day for 7 *** expression was analyzed with real-time ***:The gene expression of KATP and protein kinases in the model group was higher than those in the control group(P 0.05).CONCLUSION:Our findings suggest that electronic needling of Neiguan(PC 6) can both reduce the gene expression of KATP and protein kinases in rats with ISO-induced Ml.

关键词： Point PC6(Neiguan) Acupuncture Electric stimulation KATP Channels Protein Kinases Myocardial ischemia

A survey on recent progress in control of swarm systems

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Science China(Information Sciences) 2017年第7期60卷 5-28页

作者： Bing ZHU Lihua XIE Duo HAN xiangyu meng Rodney TEO School of Electrical and Electronic Engineering Nanyang Technological University The Seventh Research Division Beihang University Division of Systems Engineering Boston University Temasek Lab National University of Singapore

It has been witnessed that swarm systems are superior to individual agents in performing complicated tasks. In recent years, new results in some branches of control for swarm systems have developed and investigated with respect to various objectives and scenarios. This survey is to take a glimpse into some newly developed control techniques for swarm systems, especially those presented after 2013. The covered topics include some up-to-date progress in the areas of consensus, formation, flocking, containment, optimal coverage/mission planning, and sensor networks. Contributions and connections of the mentioned references are discussed *** on the new results in control of swarm systems, some possible new future research topics are suggested.

关键词： formation swarm systems consensus containment flocking sensor networks

Numerical and experimental research on axial injection end-burning hybrid rocket motors with polyethylene fuel

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Chinese Journal of Aeronautics 2024年第8期37卷 91-105页

作者： xiangyu meng Hui TIAN Lingfei HE Jingfei GAO Xiaoting NIU Guobiao CAI School of Astronautics Beihang UniversityBeijing 100191China Key Laboratory of Spacecraft Design Optimization&Dynamic Simulation Technologies Ministry of EducationBeijing 100816China

This study investigates the end-burning hybrid rocket motors with polyethylene fuel by the numerical simulation and *** on computational fluid dynamics,a numerical model is *** model is validated by two firing tests in this hybrid rocket motor,which uses oxygen and polyethylene as *** results show that the numerical and experimental data are in good agreement,and the error of the chamber pressure is less than 2.63%.Based on the simulation mode,the blowoff limit of the end-burning hybrid rocket motors is *** the nozzle throat diameter and the inner diameter of grain are large,it is more difficult for the hybrid rocket motor to achieve end-burning mode,i.e.,the flame spreading is prevented in the narrow *** main reason is that when the nozzle throat and the grain port are large,chamber pressure and oxidizer flow velocity are ***,the friction velocity considering the pressure and flow velocity is *** critical friction velocity is about 4.054–4.890 m/s in the hybrid rocket *** the friction velocity exceeds the critical friction velocity,the combustion mode in hybrid rocket motors changes from the flame spreading mode to the end-burning ***,the regression rate formula is obtained by fitting,which shows that the regression rate has a good correlation with combustion chamber *** critical friction velocity and regression rate formula can provide an important reference for end-burning hybrid rocket motors.

关键词： Hybrid rocket motor End burning Blowoff limit Flame propagation Regression rate

A comprehensive fluid-solid coupling dynamic simulation for spatiotemporal distribution of regression rate in hybrid rocket motors

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Chinese Journal of Aeronautics 2024年第9期37卷 100-112页

作者： Tianfang WEI Guobiao CAI Hui TIAN xiangyu meng Xianzhu JIANG Xiaoming GU School of Astronautics Beihang UniversityBeijing 100191China Key Laboratory of Spacecraft Design Optimization&Dynamic Simulation Technologies Ministry of Education Beijing 100191China

The spatiotemporal distribution characteristics of the regression rate are crucial aspects of the research on Hybrid Rocket Motor(HRM). This study presents a pioneering effort in achieving a comprehensive numerical simulation of fluid dynamics and heat transfer in both the fluid and solid regions throughout the entire operation of an HRM. To accomplish this, a dynamic grid technique that incorporates fluid–solid coupling is utilized. To validate the precision of the numerical simulations, a firing test is conducted, with embedded thermocouple probes being used to measure the inner temperature of the fuel grain. The temperature variations in the solid fuel obtained from both experiment and simulations show good agreement. The maximum combustion temperature and average thrust obtained from the simulations are found to deviate from the experimental results by only 3.3% and 2.4%, respectively. Thus, it can be demonstrated that transient numerical simulations accurately capture the fluid–solid coupling characteristics and transient regression rate. The dynamic simulation results of inner flow field and solid region throughout the entire working stage reveal that the presence of vortices enhances the blending of combustion gases and improves the regression rate at both the front and rear ends of the fuel grain. In addition, oscillations of the regression rate obtained in the simulation can also be well corresponded with the corrugated surface observed in the experiment. Furthermore, the zero-dimension regression rate formula and the formula describing the axial location dependence of the regression rate are fitted from the simulation results, with the corresponding coefficients of determination(R^(2)) of 0.9765 and 0.9298, *** research serves as a reference for predicting the performance of HRM with gas oxygen and polyethylene, and presents a credible way for investigating the spatiotemporal distribution of the regression rate.

关键词： Hybrid Rocket Motor(HRM) Transient numerical simulation Fluid-solid couplingheat transfer Spatiotemporal distribution of regression rate Dynamic grid

Sex bias in FGFR3 somatic mutations in bladder cancer

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Oncology and Translational Medicine 2024年第5期10卷 252-256页

作者： xiangyu meng Qiaoli Wang Health Science Center HubeiMinzuUniversityEnshiChina Department of Medical Oncology Dana-Farber Cancer Institute and Harvard Medical SchoolBostonMA

Background:Strong sex disparities have been observed among patients with bladder cancer(BCa).FGFR3 is one of the most frequently mutated genes in bladder cancer,and there are inconsistencies in its frequency in male and female ***:Here,we conducted a meta-analysis comparing the FGFR3 somatic mutation frequency in men and women among 7351 patients with BCa from 18 ***:We showed that female patients had a 1.32 times higher risk of having FGFR3 somatic mutations than *** difference was attributed to mutations occurring at the 2 most frequently mutated sites,S249 and ***,nonsense mutations were more likely to be found in women,whereas indel/frameshift mutations were almost exclusively found in men;however,no difference was noted for missense ***:A female sex bias in FGFR3 somatic mutationswas observed in ***-powered individual participant data analyses addressing the possible confounding effects of other factors(eg,age,ethnicity,smoking status,muscle invasiveness,and molecular subtype),as well as analyses integrating omics and functional investigations,are warranted to further validate and explain the mechanisms of the current findings.

关键词： bladder cancer FGFR3 sex bias somatic mutations

A Novel Routing Method for Social Delay-Tolerant Networks

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Tsinghua Science and Technology 2019年第1期24卷 44-51页

作者： xiangyu meng Gaochao Xu Tingting Guo Yongjian Yang Wenxu Shen Kuo Zhao the Department of Computer Science and Technology Jilin University the Department of Software Engineering Jilin University the Training Department Aviation University of Air Force

The lack of continuous connectivity and a complete path from source to destination makes node communication quite difficult in Delay-Tolerant Networks(DTNs). Most studies focus on routing problems in idealized network environments without considering social properties. Communication devices are carried by individuals in many DTNs; therefore, DTNs are unique social networks to some extent. To design efficient routing protocols for DTNs, it is important to analyze their social properties. In this paper, a more accurate and comprehensive metric for detecting the quality of the relationships between nodes is proposed, by considering the contact time, contact frequency, and contact regularity. An overlapping hierarchical community detection method is designed based on this new metric, and a tree structure is built. Furthermore, we exploit the overlapping community structure and the tree structure to provide message-forwarding paths from the source node to the destination *** simulation results show that our Routing method based on Overlapping hierarchical Community Detection(ROCD) achieves better delivery rate than SimBet and Bubble Rap, the classic routing protocols, without affecting the average delay.

关键词： Delay-Tolerant Network (DTN) social properties overlapping community hierarchical routing

Role of endovascular embolisation for curative treatment of intracranial non- Galenic pial arteriovenous fistula

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Stroke & Vascular Neurology 2021年第2期6卷 260-266页

作者： Hengwei Jin xiangyu meng Jiale Quan Yi Lu Youxiang Li Department of Interventional Neuroradiology Beijing Tiantan HospitalBeijingChina Interventional Neuroradiology department Beijing Neurosurgical InstituteBeijingChina Pediatric department Dongming People’s HospitalBeijingChina Department of Interventional Neuroradiology Beijing Neurosurgical InstituteBeijingChina

Background and purpose The safety and effectiveness of endovascular treatment for non-Galenic pial arteriovenous fistula(NGPAVF)is inadequately *** aim of this study is to explore the role of endovascular embolisation for curative treatment of *** and methods Patients with NGPAVF underwent endovascular treatment from January 2011 to November 2019 in our institution were retrospectively ***,clinical information,treatment details and clinical outcomes were *** associated with clinical outcomes were statistically *** Twenty patients were included,with a total of 22(2 patients have 2 fistulas)lesions.A total of 25 procedures were performed and 5 patients underwent 2 ***-up ranged from 3 to 84 months(mean=34.5 months).Thirteen(59.1%)lesions in 12(60.0%)patients acquired immediate occlusion after initial treatment(immediately occluded group)and follow-up confirmed the complete obliteration.A total of 17(77.3%)lesions in 15(75.0%)patients were cured at last *** maximal diameter of feeding arteries(p=0.04)and the maximal diameter of the varix(p=0.01)in immediately occluded group was smaller than non-immediately occluded *** number of feeding artery(p=0.004)and the maximal diameter of the varix(p<0.001)were much smaller in curative group than non-curative *** patients suffered procedure-related *** patients had an increased Modified Rankin Scale(mRS)and all patients had favourable clinical outcome(mRS≥2)at last *** Endovascular therapy plays an important role in curative treatment of *** with less feeding arteries and small varix may be easier to be cured by endovascular embolisation.

关键词： curative fistula treatment

Petroleum in the Jurassic Reservoirs within the Eastern Fukang Sub-depression,Junggar Basin,NW China:Correlation and Source Rock

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Acta Geologica Sinica(English Edition) 2023年第3期97卷 777-795页

作者： CHENG Bin LIU Hua ZHANG Kuihua REN Xincheng meng xiangyu LIU Dezhi Shandong Provincial Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong 266580China Shandong Provincial Key Laboratory of Reservoir Geology China University of Petroleum(East China)QingdaoShandong 266580China Laboratory for Marine Mineral Resources Qingdao National Laboratory for Marine Science and TechnologyQingdaoShandong 266071China Sinopec Shengli Oilfield Company DongyingShandong 257000China

The origin and source of the petroleum in the Jurassic reservoirs within the eastern Fukang sub-depression were geochemically *** show thermal maturities matching the peak generation stage,while the condensates are at the early stage of intense *** and condensates may have experienced mild evaporative fractionation,while mixing of severely biodegraded with non-biodegraded oils has *** biomarkers and isotopes,petroleums were classified into GroupⅠ,ⅡandⅢgenetic groups,with GroupⅢfurther divided intoⅢa andⅢb ***Ⅰpetroleum displays heavy carbon isotopes,a strong predominance of pristine over phytane,high C_(19)and C_(20)tricyclic and C_(24)tetracyclic terpanes,low gammacerane,and dominant C_(29)steranes,while GroupⅡshows light carbon isotopes,a predominance of phytane over pristine,high C_(21)and C_(23)tricyclic with low C_(24)tetracyclic terpanes,high gammacerane and dominant C_(27)***Ⅲa petroleum shows mixing compositions of GroupⅠandⅡ,while GroupⅢb displays similar compositions to Group I,but with significantly higher Ts,C_(29)Ts and C_(30)diahopane ***-source rock correlation suggests GroupⅠandⅡpetroleums originate from Jurassic and Permian source rocks,respectively,while GroupⅢa are mixtures sourced from these rocks andⅢb are mixtures from Jurassic and Triassic source rocks.

关键词： biomarkers oil-source rock correlation Jurassic reservoirs Fukang sub-depression Junggar Basin

Smart design of high‐performance surface‐enhanced Raman scattering substrates

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SmartMat 2021年第4期2卷 466-487页

作者： xiangyu meng Lin Qiu Guangcheng Xi Xiaotian Wang Lin Guo School of Chemistry Beihang UniversityBeijingChina School of Energy and Environmental Engineering University of Science and Technology BeijingBeijingChina Institute of Industrial and Consumer Product Safety Chinese Academy of Inspection and QuarantineBeijingChina

Surface‐enhanced Raman scattering(SERS)spectroscopy has renowned its fame for the ultra‐high sensitivity and single‐molecule detection ability,and listed as a fingerprint spectrum representative in various trace detection *** efforts have been made by researchers to design high‐sensitive SERS‐active substrates ranging from noble metals to *** review summarizes the fundamental theories for SERS technique,that is,the electromagnetic enhancement mechanism and chemical enhancement mechanism and the state‐of‐the‐art design strategies for noble metal and semiconductor *** also sheds light on the effective approaches to improve the SERS activity for noble metal substrates,that is,tuning the localized surface plasmon resonance position,the assembling of hot spots,and precise controlling of *** charge transfer is considered as the main reason for the enhancement mechanism for semiconductors at the present stage,the underlying theoretical basis remains *** review summarized the critical points for SERS‐active substrates design and prospected the future development direction of SERS technology.

关键词： applications enhancement mechanisms SERS‐active nanomaterials smart substrate design