Sex bias in FGFR3 somatic mutations in bladder cancer

作     者：Xiangyu Meng Qiaoli Wang Xiangyu Meng;Qiaoli Wang

作者机构：Health Science CenterHubeiMinzuUniversityEnshiChina Department of Medical OncologyDana-Farber Cancer Institute and Harvard Medical SchoolBostonMA 

出 版 物：《Oncology and Translational Medicine》 (肿瘤学与转化医学（英文版）)

年 卷 期：2024年第10卷第5期

页      面：252-256页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China(no.82303057) Natural Science Foundation of Hubei Province of China(no.2023AFB521) “Chutian Scholars Program”of Hubei Province of China 

主　　题：bladder cancer FGFR3 sex bias somatic mutations 

摘      要：Background:Strong sex disparities have been observed among patients with bladder cancer(BCa).FGFR3 is one of the most frequently mutated genes in bladder cancer,and there are inconsistencies in its frequency in male and female ***:Here,we conducted a meta-analysis comparing the FGFR3 somatic mutation frequency in men and women among 7351 patients with BCa from 18 ***:We showed that female patients had a 1.32 times higher risk of having FGFR3 somatic mutations than *** difference was attributed to mutations occurring at the 2 most frequently mutated sites,S249 and ***,nonsense mutations were more likely to be found in women,whereas indel/frameshift mutations were almost exclusively found in men;however,no difference was noted for missense ***:A female sex bias in FGFR3 somatic mutationswas observed in ***-powered individual participant data analyses addressing the possible confounding effects of other factors(eg,age,ethnicity,smoking status,muscle invasiveness,and molecular subtype),as well as analyses integrating omics and functional investigations,are warranted to further validate and explain the mechanisms of the current findings.