Effect of electronic stimulation at Neiguan(PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia

作     者：Wang Wei Li Jiquan Meng Xiangyu Chen Yiguo 

作者机构：College of Acupuncture and MassageLiaoning University of Traditional Chinese Medicine 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2015年第35卷第5期

页      面：577-582页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：Supported by National Basic Research Program of China(973 Program) Study on Biological Foundation of Response in Target Organ to Meridian Specificity of Acupoint Effect(No.2012CB518503) 

主　　题：Point PC6(Neiguan) Acupuncture Electric stimulation KATP Channels Protein Kinases Myocardial ischemia 

摘      要：OBJECTIVE:To investigate the effects of electronic stimulation at acupoints Neiguan(PC 6) and Lieque(LU 7) on the gene expression of the adenosine triphosphate(ATP)-Sensitive potassium channel(KATP:Kir6.1,Kir6.2,SUR2 A,and SUR2B) and protein kinases(PKA,PKG,and PKCβ2) in myocardial cells of rats with myocardial ischemia(Ml) induced by isoproterenol(ISO).METHODS:Rats were randomly divided into a control,model,Neiguan(PC 6),Lieque(LU 7),and non-acupoint *** Ml model was established by injecting rats with ***-acupuncture treatment was given to the acupuncture groups,once a day for 7 *** expression was analyzed with real-time ***:The gene expression of KATP and protein kinases in the model group was higher than those in the control group(P 0.05).CONCLUSION:Our findings suggest that electronic needling of Neiguan(PC 6) can both reduce the gene expression of KATP and protein kinases in rats with ISO-induced Ml.