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Cardiology Discovery 2024年第1期4卷 55-57页

作者： Huanan Liu Zhaoming Lin Xiaoshen Zhang Department of Cardiovascular Surgery The First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Abdominal complications following cardiac surgery are rare events,but can be fatal if not diagnosed and managed in *** treatments offer a better chance for survival in patients with risk *** case report describes the clinical presentation and details of 3 recently operated patients who suffered acute abdominal pain after cardiac *** underlying causes were Crohn disease-associated ileal perforation,intestinal necrosis,and diverticulitis-associated colonic *** presentation and management of these severe conditions are discussed.

关键词： Abdominal pain Cardiac surgery Ulceration ischemia Diverticulitis

Injury/ischemia-induced stem cells: up-to-date knowledge and future perspectives for neural regeneration

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Neural Regeneration Research 2025年第3期20卷 797-798页

作者： Takayuki Nakagomi Institute for Advanced Medical Sciences Hyogo Medical UniversityNishinomiyaJapan Department of Therapeutic Progress in Brain Diseases Hyogo Medical UniversityNishinomiyaJapan

Brain injuries like ischemic stroke induce endogenous stem cell production. Although the precise traits of stem cells in pathological brains remain unclear, we previously demonstrated that injury/ischemia-induced stem... 详细信息

关键词： ischemia injuries

Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6

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Chinese Medical Journal 2022年第20期135卷 2467-2477页

作者： Yimeng Chen Congya Zhang Yingjie Du Xiying Yang Min Liu Wenjing Yang Guiyu Lei Guyan Wang Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Weifang Medical University School of AnesthesiologyShandong Provincial Medicine and Health Key Laboratory of Clinical AnesthesiaWeifangShandong 261053China

Background:Acute kidney injury(AKI)is a common complication in patients,especially elderly patients,who undergo cardiac surgery with cardiopulmonary *** have indicated a protective role of autophagy in ***,the mechanisms underlying the regulatory effect of autophagy in AKI among patients undergoing cardiac surgeries are poorly *** this study,we aimed to test the hypothesis that exosomal microRNAs(miRNAs)regulate autophagy in tubular epithelial cells after ***:Plasma exosomal RNA was extracted from young and elderly AKI patients undergoing cardiac surgery,and the miRNAs expression during the perioperative period were analyzed using next-generation *** screened miRNAs and their target genes were subjected to gene oncology function and Kyoto Encyclopedia of Genes and Genome enrichment *** tubular epithelial cell line(HK-2 cells)was cultured and hypoxia/reoxygenation(H/R)model was established,which is an in vitro renal ischemia/reperfusion(I/R)*** used Western blot analysis,cell viability assay,transfection,luciferase assay to investigate the mechanisms underlying the observed increases in the levels of renal I/R injury-mediated exosomal miRNAs and their roles in regulating HK-2 cells ***:miR-590-3p was highly enriched in the plasma exosomes of young AKI patients after cardiac *** levels of miR-590-3p led to the increases in the expression of autophagy marker proteins,including Beclin-1 and microtubule associated protein 1 light chain 3 beta(LC3II),and prolonged the autophagic response in HK-2 cells after H/R *** effects were achieved mainly via increases in the exosomal miR-590-3p levels,and the tumor necrosis factor receptor-associated factor 6 protein was shown to play a key role in I/R injury-mediated autophagy ***:Exosomes released from HK-2 cells after renal I/R injury regulate autophagy by transferring miR-590-3p in a paracrine manner,which sug

关键词： Acute kidney injury Autophagy Exosome Hypoxia ischemia miR-590-3p Reperfusion

Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury:Cumulative evidence for future cardioprotective strategies

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Acta Pharmaceutica Sinica B 2023年第1期13卷 29-53页

作者： Panat Yanpiset Chayodom Maneechote Sirawit Sriwichaiin Natthaphat Siri-Angkul Siriporn C.Chattipakorn Nipon Chattipakorn Cardiac Electrophysiology Research and Training Center Faculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Cardiac Electrophysiology Unit Department of PhysiologyFaculty of MedicineChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Cardiac Electrophysiology Research Chiang Mai UniversityChiang Mai 50200Thailand Department of Oral Biology and Diagnostic Sciences Faculty of DentistryChiang Mai UniversityChiang Mai 50200Thailand

Cardiomyocyte death is one of the major mechanisms contributing to the development of myocardial infarction(MI)and myocardial ischemia/reperfusion(MI/R)*** to the limited regenerative ability of cardiomyocytes,understanding the mechanisms of cardiomyocyte death is ***,one of the regulated programmed cell death pathways,has recently been shown to play important roles in MI and MI/R *** is activated by damage-associated molecular patterns(DAMPs)that are released from damaged myocardial cells and activate the formation of an apoptosisassociated speck-like protein containing a CARD(ASC)interacting with NACHT,LRR,and PYD domains-containing protein 3(NLRP3),resulting in caspase-1 cleavage which promotes the activation of Gasdermin D(GSDMD).This pathway is known as the canonical *** has also been shown to be activated in a non-canonical pathway during MI and MI/R injury via caspase-4/5/*** of GSDMD has been shown to provide cardioprotection against MI and MI/R *** the effects of MI or MI/R injury on pyroptosis have previously been discussed,knowledge concerning the roles of GSDMD in these settings remains *** this review,the evidence from in vitro,in vivo,and clinical studies focusing on cardiac GSDMD activation during MI and MI/R injury is comprehensively summarized and *** from this review will help pave the way for a new therapeutic target in ischemic heart disease.

关键词： Pyroptosis Gasdermin D Heart ischemia ischemia-reperfusion injury Myocardial infarction

Effective therapy of the small-molecule cocktail 5SM on adult rat heart after ischemia–reperfusion injury

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Journal of Molecular Cell Biology 2023年第6期15卷 65-67页

作者： Lixia Zheng Yuanyuan Chen Zhengyuan Wu Xiaojun Zhu Jing-Wei Xiong Beĳing Key Laboratory of Cardiometabolic Molecular Medicine Institute of Molecular MedicineCollege of Future Technologyand State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeĳing 100871China PKU-Nanjing Institute of Translational Medicine Nanjing 211800China

Dear Editor,Myocardial infarction(MI)is one of the leading causes of cardiovascular-related mortality *** restoration of the blood supply to ischemic my-ocardium by thrombolysis or percuta-neous coronary intervention ... 详细信息

关键词： mortality cardiovascular ischemia

Non-cerebral vasospasm factors and cerebral vasospasm predict delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage

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Chinese Medical Journal 2022年第2期135卷 222-224页

作者： Yue Chen Guanmin Li Xiaoyong Chen Dengliang Wang Wenhua Fang Dezhi Kang Chenyu Ding Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated Hospital of Fujian Medical UniversityFujian Provincial Key Laboratory of Precision Medicine for CancerFuzhouFujian 350001China Department of Plastic Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350001China The Graduate School of Fujian Medical University FuzhouFujian 350001China

Aneurysmal subarachnoid hemorrhage(aSAH)is a typical neurosurgical *** patient's prognosis is related to the severity of the initial illness and post-operative complications,especially delayed cerebral ischemia(DCI).DCI,which occurs in up to 30%of patients with subarachnoid hemorrhage(SAH),usually 2 weeks after hemorrhage,is one of the leading causes of death and disability in aSAH.

关键词： cerebral hemorrhage ischemia operative death after

Integration of ATAC-Seq and RNA-Seq identifies the key genes in myocardial ischemia

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Genes & Diseases 2023年第1期10卷 62-64页

作者： Jing Yuan Jun-Meng Wang Zhi-Wei Li Cheng-Shun Zhang Bin Cheng Su-Hao Yang Ding-Jun Cai Shu-Guang Yu Acupuncture and Tuina School/Third Teaching Hospital Chengdu University of Traditional Chinese MedicineChengduSichuan 610075China

Myocardial ischemia(Ml)is a common disease with high mortality and morbidity *** the pathological process of MI is very complicated,a comprehensive understanding of its pathogenesis is the key to the treatment of *** chromatin plays a crucial role in regulating gene expression,and gene regulation is a fundamental process in developing and disease progression,combined analysis of the chromatin and gene can further reveal the pathological mechanism of Ml.

关键词： ischemia mortality pathogenesis

Restoration of GABA_(B) receptor expression in cerebral ischemia:a promising novel neuroprotective strategy

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Neural Regeneration Research 2023年第12期18卷 2659-2660页

作者： Musadiq A.Bhat Mohammad Hleihil Dietmar Benke Institute of Pharmacology and Toxicology University of ZurichZurichSwitzerland

Although stroke is a major global health problem, a pharmacological treatment to inhibit ongoing neuronal death in patients is still lacking. In cerebral ischemia, the prevailing form of stroke, severely reduced blood supply by obstruction of blood vessels deprives neurons from oxygen and glucose, eventually leading to metabolic derailment and death of neurons in the affected brain area.

关键词： cerebral ischemia death

ischemia/reperfusion injury in porcine intestine-Viability assessment

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World Journal of Gastroenterology 2018年第18期24卷 2009-2023页

作者： Runar J Strand-Amundsen Henrik M Reims Finn P Reinholt Tom E Ruud Runkuan Yang Jan O Hogetveit Tor I Tonnessen Department of Clinical and Biomedical Engineering Oslo University HospitalOslo 0424Norway Department of Physics University of OsloOslo 0316Norway Department of Pathology Oslo University HospitalOslo 0424Norway Institute for Surgical Research Oslo University HospitalOslo 0424Norway Department of Surgery Baerum HospitalVestre Viken Hospital TrustDrammen 3004Norway Department of Emergencies and Critical Care Oslo University HospitalOslo 0424Norway Institute of Clinical Medicine University of OsloOslo 0424Norway

AIM To investigate viability assessment of segmental small bowel ischemia/reperfusion in a porcine *** In 15 pigs, five or six 30-cm segments of jejunum were simultaneously made ischemic by clamping the mesenteric arteries and veins for 1 to 16 h. Reperfusion was initiated after different intervals of ischemia(1-8 h) and subsequently monitored for 5-15 h. The intestinal segments were regularly photographed and assessed visually and by palpation. Intraluminal lactate and glycerol concentrations were measured by microdialysis, and samples were collected for light microscopy and transmission electron microscopy. The histological changes were described and *** Using light microscopy, the jejunum was considered as viable until 6 h of ischemia, while with transmission electron microscopy the ischemic muscularis propria was considered viable until 5 h of ischemia. However, following ≥ 1 h of reperfusion, only segments that had been ischemic for ≤ 3 h appeared viable, suggesting a possible upper limit for viability in the porcine mesenteric occlusion model. Although intraluminal microdialysis allowed us to closely monitor the onset and duration of ischemia and the onset of reperfusion, we were unable to find sufficient level of association between tissue viability and metabolic markers to conclude that microdialysis is clinically relevant for viability assessment. Evaluation of color and motility appears to be poor indicators of intestinal *** Three hours of total ischemia of the small bowel followed by reperfusion appears to be the upper limit for viability in this porcine mesenteric ischemia model.

关键词： Viability histology reperfusion ischemia microdialysis jejunum porcine model

Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury

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Neural Regeneration Research 2013年第33期8卷 3087-3094页

作者： Yiming Ji Bin Meng Chenxi Yuan Huilin Yang Jun Zou Department of Orthopedic Surgery the First Affiliated Hospital of Soochow University

It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials. Therefore, we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology. The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia. After reperfusion for 30-180 minutes, the amplitude and latency began to gradually recover; at 360 minutes of reperfusion, the latency showed no significant difference compared with the pre-ischemic value, while the somatosensory evoked potential amplitude in- creased, and severe hindlimb motor dysfunctions were detected. Experimental findings suggest that changes in somatosensory evoked potentia~ ~atency can reflect the degree of spinat cord ischemic injury, while the amplitude variations are indicators of the late spinal cord reperfusion injury, which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury.

关键词： neural regeneration spinal cord injury somatosensory evoked potentials spinal cord ischemia reperfusion iatrogenic spinal cord injury histopathology abdominal aorta occlusion model latency grants-supported paper neuroregeneration