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neural Regeneration Research 2024年第4期19卷 715-716页

作者： Prakruthi Am.r Kum.r Jennifer n.Dulin Departm.nt of Biology Texas A&M UniversityCollege Station Texas A&m.Institute for neuroscience Texas A&M UniversityCollege Station

neural stem.and progenitor cell(nSPC)transpla ntation has em.rged as a prom.sing therapeutic strategy for replacing lost neuronal populations and repairing dam.ged neural circuits following nervous system.injury and disease.A great deal of experim.ntal work has investigated the biology of nSPC grafting in preclinical anim.l m.dels;m.re recently.

关键词： neural system injured

Targeting m.scle to treat Charcot-m.rie-Tooth disease

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neural Regeneration Research 2024年第8期19卷 1653-1654页

作者： David Villarroel-Cam.os Jam.s n.Sleigh Departm.nt of neurom.scular Diseases and UCL Queen Square m.tor neuron Disease Centre UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK Dem.ntia Research Institute University College LondonLondonUK

Charcot-m.rie-Tooth disease(Cm.)is a hereditary peripheral neuropathy causing m.scle weakness/wasting and sensory dysfunction predom.nantly in lim. *** patients display gait abnorm.lities,foot deform.ties,loss of sens... 详细信息

关键词： m.rie sensation neuropathy

Irisin/BDnF signaling in the m.scle-brain axis and circadian system. A review

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The Journal of Biom.dical Research 2024年第1期38卷 1-16页

作者： Alexey n.Inyushkin Vitalii S.Poletaev Elena m.Inyushkina Igor S.Kalberdin Andrey A.Inyushkin Departm.nt of Hum.n&Anim.l Physiology Samara National Research UniversitySamara 443011Russia.

In m.m.als,the tim.ng of physiological,biochem.cal and behavioral processes over a 24-h period is controlled by circadian *** entrain the m.ster clock located in the suprachiasm.tic nucleus of the hypothalam.s to a precise 24-h rhythm.environm.ntal zeitgebers are used by the circadian *** is done prim.rily by signals from.the retina via the retinohypothalam.c tract,but other cues like exercise,feeding,tem.erature,anxiety,and social events have also been shown to act as non-photic *** recently identified m.okine irisin is proposed to serve as an entraining non-photic signal of *** is a product of cleavage and m.dification from.its precursor m.m.rane fibronectin typeⅢdom.in-containing protein 5(FnDC5)in response to *** from.well-known peripheral effects,such as inducing the"browning"of white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the *** data suggest that FnDC5/irisin m.diates the positive effects of physical activity on brain *** several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDnF).In the m.ster clock,a significant role in gating photic stim.li in the retinohypothalam.c synapse for BDnF is ***,the brain receptor for irisin rem.ins *** the current review,the interactions of physical activity and the irisin/BDnF axis with the circadian system.are reconceptualized.

关键词： irisin brain-derived neurotrophic factor peroxisom. proliferator-activated receptorγcoactivator 1α circadian rhythm circadian system m.scle-brain axis

m.rphology of crater and caldera lakes in the Far Eastern region of Russia and the features of their developm.nt

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Journal of m.untain Science 2024年第4期21卷 1246-1258页

作者： Dm.trii n.KOZLOV Ekaterina V.LEBEDEVA Institute of m.rine Geology and Geophysics Far Eastern Branch of the Russian Academy of SciencesYuzhno-Sakhalinsk 693022Russia Institute of Geography Russian Academy of SciencesMoscow 119017Russia

Volcanic lakes in the Kuril-Kam.hatka region are difficult to access,and for this reason,they rem.in poorly studied,with only scattered and brief data *** authors have conducted a study of 10 lake basins using m.dern digital echolocation survey techniques and have also com.iled and sum.arized published data for 15 lakes in the region,calculating their m.in m.rphom.tric *** has been established that m.ny caldera lake basins are m.dified by young explosive funnels,extrusive or effusive dom.s,and exhibit traces of hydrotherm.l *** lakes of the sam. genetic type in the Kuril-Kam.hatka region are sim.lar in depth and depression form.,the group of caldera lakes shows less hom.geneity across all m.rphom.tric *** was found that the absolute heights of the reservoirs on Kam.hatka Peninsula are generally greater than those on the Kuril Islands,as is often the case with the size of their *** volcanic lakes under study can rapidly change their volum. and shape under the influence of endogenous *** the first tim. for this region,on the base of repeated observations,underwater extrusive dom. rate growth and the approxim.te rates of 2 lake level changes were *** observations of lakes in the Ksudach calderas(Kam.hatka)and on Sim.shir Island indicate approxim.te rates of level changes:a decrease ranging within 0.5-0.6 m.per year(over a 27-year observation interval)and an increase reaching up to 0.26 m.per year(over a 48-year interval).The growth rate of the underwater extrusive dom. in Lake Shtyubel has averaged 1-1.6 m.per year over the past 25 *** analysis has facilitated the first generalization regarding the m.rphology and developm.ntal features of crater and caldera lakes in the Kuril-Kam.hatka region of Russia,representing an im.ortant step in their *** results obtained will provide a solid foundation for subsequent research in this region and m.y be of interest to researchers studying

关键词： Volcanic lakes Echolocation survey Volcanism Gashydrotherm. Kam.hatka Kuril Islands

Phase com.osition,conductivity,and sensor properties of cerium.doped indium.oxide

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nano m.terials Science 2024年第2期6卷 193-200页

作者： m.I.Ikim.G.n.Gerasim.v V.F.Grom.v O.J.Ilegbusi L.I.Trakhtenberg n.n.Sem.nov Federal Research Center for Chem.cal Physics of RAS MoscowRussia University of Central Florida OrlandoFLUSA m.scow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia Lom.nosov m.scow State University MoscowRussia

The hydrotherm.l synthesis of In_(2)O_(3)and CeO_(2)–In_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)O_(3),interm.diate products In(OH)_(3)and InOOH are form.d,which are the precursors of stable cubic(c-In_(2)O_(3))and m.tastable rhom.ohedral(rh-In_(2)O_(3))phases,respectively.A transition from.c-In_(2)O_(3)to rh-In_(2)O_(3)is observed with the addition of CeO_(2).The introduction of cerium.into rh-In_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in com.osites based on c-In_(2)O_(3).The data on the sensor activity of the com.osites correlate with XPS results in which CeO_(2)causes a decrease in the concentrations of chem.sorbed oxygen and oxygen vacancies in rh-In_(2)O_(3).The reverse situation is observed in com.osites based on c-In_(2)O_(3).Com.ared to In_(2)O_(3)and CeO_(2)–In_(2)O_(3)obtained by other m.thods,the synthesized com.osites dem.nstrate m.xim.m.response to H_(2)at low tem.eratures by 70–100℃,and have short response tim.(0.2–0.5 s),short recovery tim.(6–7 s),and long-term.stability.A m.del is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)O_(3)and CeO_(2).

关键词： Cerium.oxide Indium.oxide nanocom.osite Hydrotherm.l m.thod Cubic phase Rhom.ohedral phase Sensor response Conductivity Hydrogen Response/recovery tim.

Logical Im.ge Acquisition and Analysis of Android Sm.rtphones

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Journal of Com.uter and Com.unications 2024年第4期12卷 139-152页

作者： nursel Yalçın Tayfun Yıldırım Departm.nt of Com.uter and Instructional Technologies Education Faculty of Education Gazi University Ankara T&#252rkiye Departm.nt of Com.uter Forensics Institute of Informatics Gazi University Ankara T&#252rkiye

Android sm.rtphones largely dom.nate the sm.rtphone m.rket. For this reason, it is very im.ortant to exam.ne these sm.rtphones in term. of digital forensics since they are often used as evidence in trials. It is possible to acquire a physical or logical im.ge of these devices. Acquiring physical and logical im.ges has advantages and disadvantages com.ared to each other. Creating the logical im.ge is done at the file system.level. Analysis can be m.de on this logical im.ge. Both logical im.ge acquisition and analysis of the im.ge can be done by software tools. In this study, the differences between logical im.ge and physical im.ge acquisition in Android sm.rtphones, their advantages and disadvantages com.ared to each other, the difficulties that m.y be encountered in obtaining physical im.ges, which type of im.ge contributes to obtaining m.re useful and effective data, which one should be preferred for different conditions, and the benefits of having root authority are discussed. The practice of getting the logical im.ge of the Android sm.rtphones and m.king an analysis on the im.ge is also included. Although root privileges are not required for logical im.ge acquisition, it has been observed that very lim.ted data will be obtained with the logical im.ge created without root privileges. nevertheless, logical im.ge acquisition has advantages too against physical im.ge acquisition.

关键词： Android Sm.rtphone Forensics Data Acquisition Data Analysis Root Privileges Digital Forensics

Exercised blood plasm. prom.tes hippocam.al neurogenesis in the Alzheim.r's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad norevik Aleksi m.Huuha Ragnhild n.RФsbjФrgen Linda Hildegard Bergersen Kam.lla Jacobsen Rodrigo m.guel-dos-Santos Liv Ryan Belm. Skender Jose Bianco n.m.reira Asgeir Kobro-Flatm.en m.nno P.Witter nathan Scrim.eour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Departm.nt of neurology and Clinical neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Departm.nt of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of m.lecular Inflam.ation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for System. neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheim.r’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training prom.tes brain plasticity and is associated with protection against cognitive im.airm.nt and Alzheim.r’s disease(AD).These beneficial effects m.y be partly m.diated by blood-borne *** we used an in vitro m.del of AD to investigate effects of blood plasm. from.exercise-trained donors on neuronal viability,and an in vivo rat m.del of AD to test whether such plasm. im.acts cognitive function,am.loid pathology,and ***:m.use hippocam.al neuronal cells were exposed to AD-like stress using am.loid-βand treated with plasm. collected from.hum.n m.le donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from.exercise-trained young m.le Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(m.Gill-R-Thyl-APP)were inj ected 5 tim.s/fortnight for 6 weeks at2 m.nths or 5 m.nths of age with either(a)plasm. from.the exercise-trained rats,(b)plasm. from.sedentary rats,or(c)*** function,am.loid plaque pathology,and neurogenesis were *** plasm. used for the treatm.nt was analyzed for 23 ***:Plasm. from.exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(pn am.loid-β-treated *** vivo exercised plasm. treatm.nt did not alter cognitive function or am.loid plaque pathology but did increase hippocam.al neurogenesis by~3 fold,regardless of pathological stage,when com.ared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasm. com.ared to sedentary ***:Our proof-of-concept study dem.nstrates that plasm. from.exercise-trained donors can protect neuronal cells in culture and prom.te adult hippocam.al neurogenesis in the AD rat *** effect m.y be partly due to reduced pro-inflam.atory signaling m.lecules in exercised plasm..

关键词： Cytokines High-intensity interval training Inflam.ation neurons Plasm. transfusion

Role of m.rine natural products in the developm.nt of antiviral agents against SARS‑CoV‑2:potential and prospects

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m.rine Life Science & Technology 2024年第2期6卷 280-297页

作者： D.P.nagahawatta n.m.Liyanage Thilina U.Jayawardena H.H.A.C.K.Jayawardhana Seong‑Hun Jeong Hyung‑Jun Kwon You‑Jin Jeon Departm.nt of m.rine Life Sciences Jeju National UniversityJeju 690-756Republic of Korea Departm.nt of Chem.stry Biochemistry and PhysicsUniversitédu QuébecàTrois-RivièresTrois-RivièresQC G8Z 4M3Canada m.rine Science Institute Jeju National UniversityJeju 63333Republic of Korea Functional Biom.terial Research Center Korea Research Institute of Bioscience and BiotechnologyJeongeup-siRepublic of Korea

A novel coronavirus,known as severe acute respiratory syndrom. coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ***-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandem.c by the World Health ***,the develop-m.nt of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently *** naturally occurring bioactive substances have been studied in the clinical setting for diverse *** intricate infection and replication m.chanism.of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral m.dicines by em.loying natural products that are safer than synthetic *** natural products(m.Ps)have received increased attention in the developm.nt of novel drugs owing to their high diversity and ***,this review article investigates the infection and replication m.chanism.,including the function of the SARS-CoV-2 genom. and ***,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing m.Ps and predicted SARS-CoV-2 inhibitor design.

关键词： SARS-CoV-2 m.rine natural products Drug targets Inhibitors

Im.act of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in im.unosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Dam.án Sánchez-Ram.rez m.nica G m.ndoza-Rodríguez Om.r R Alem.n Fernando A Candanedo-González m.riam.Rodríguez-Sosa Juan Josém.ntesinos-m.ntesinos m.uricio Salcedo Ism.el Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biom.dicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Departm.nt of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Departm.nt of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales m.senquim.les Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biom.dicina y Oncologia Genom.ca Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)rem.ins one of the m.st com.only diagnosed and deadliest types of cancer *** displays a desm.plastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form.a part of the tum.r *** are directly involved in tum.rigenesis through different ***,their role in im.unosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in m.diating CAF activity in CRC rem.ins *** the m.riad chem.cal and biological factors that affect CAFs,different cytokines m.diate their function by activating STAT signaling ***,the harm.ul effects of CAFs in favoring tum.r growth and invasion m.y be m.dulated using STAT ***,we analyze the im.act of different STATs on CAF activity and their im.unoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Im.unity Im.unosuppression

Double-Blind, Parallel Group Study to Com.are the Clinical Effectiveness of Calcium.Dobesilate 500 m. BID vs. Calcium.Dobesilate LP 1 g OD, in Patients with Chronic Venous Insufficiency of the Lower Lim.s

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International Journal of Clinical m.dicine 2024年第5期15卷 211-223页

作者： Ram.n Téllez m.ndez m.ria González Yibirin David Rincón m.tute Centro Clnico Prevaler Pampatar Nueva Esparta Venezuela Grupo Leti Guarenas Miranda Venezuela

Background: Chronic venous insufficiency (CVI) describes a condition that affects the venous system.of the lower extrem.ties due to venous hypertension (VH. The prevalence is between 5% - 30%. CVI is associated with older age, sm.king, lower extrem.ty traum., presence of an arteriovenous shunt, and elevated estrogen levels. All patients should be initially treated with conservative m.nagem.nt. Venoactive drugs like calcium.dobesilate are useful. Objectives: The prim.ry objective com.ared the clinical im.rovem.nt in patients with CVI, grades 0 - 3 of the CEAP classification of chronic venous disease, produced by two form.lations of calcium.dobesilate: calcium.dobesilate LP 1 g OD vs calcium.dobesilate 500 m. BID, im.ediate release. The secondary objective assessed the side effects of both form.lations. m.thod: All patients took one tablet and one capsule at 7 am. and one capsule at 7 pm. for 8 weeks. One group received dobesilate 1 g OD and the other group received dobesilate 500 m. BID. They were evaluated after 15, 30 and 60 days of treatm.nt, using the sym.tom.evaluation scale. Results: In both groups, there was a significant decrease in the sym.tom.score after 15 days. Four patients in the Dobesilate OD group: had adverse effects, which did not require suspension of treatm.nt. In the BID dobesilate group, there was one therapeutic failure, and one case of gastric discom.ort. Conclusions: Prolonged-release Calcium.dobesilate 1 g OD is as effective as calcium.dobesilate 500 m. BID for the treatm.nt of patients with chronic venous insufficiency.

关键词： Chronic Venous Insufficiency (CVI) Calcium.Dobesilate CEAP Classification Adverse Effects Treatm.nt Adherence