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Acute pancreatitis associated with intravenous administration of propofol:evaluation of causality in a systematic review of the literature

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Gastroenterology Report 2019年第1期7卷 13-23,I0001页

作者： Samir Haffar Ravinder Jeet Kaur Sushil Kumar Garg Joseph A.Hyder m.hassan murad Barham K.Abu Dayyeh Fateh Bazerbachi Digestive Center for Diagnosis&Treatment 29 Ayar StreetDamascusSyrian Arab Republic Division of Gastroenterology and Hepatology Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Anesthesiology and Perioperative medicine Mayo Clinic200 First Street SWRochesterMN 55905USA Division of Health Care Policy and Research Mayo Clinic200 First Street SWRochesterMN 55905USA

Acute pancreatitis(AP)associated with intravenous administration of propofol has been described with unknown causal *** therefore assessed this causality in a systematic *** databases were searched on 16 August 2017;studies were appraised and selected by two reviewers based on a priori *** causality was evaluated with the Naranjo scale and Badalov *** identified 18 studies from 11 countries with a total of 21 patients,and the majority had adequate methodological *** median age was 35 years(range,4–77)and 10(48%)were ***,propofol was administrated in 8 patients as sedative along with induction/maintenance of anesthesia in 13 patients;median dose was 200 mg,with intermediate latency(1–30 days)in 14(67%).Serum triglycerides were>1000 mg/dL in four *** AP was observed in four patients(19%).AP recurrence occurred in one out of two patients who underwent *** related to AP was 3/21(14%).Propofol was the probable cause of AP according to the Naranjo scale in 19 patients(89%).Propofol-induced AP has a probable causal relation and evidence supports Badalov class *** is not the only mechanism by which propofol illicit ***-induced AP was severe in 19%of patients with a mortality rate related to AP of 14%.Future research is needed to delineate whether this risk is higher if combined with other procedures that portend inherent risk of pancreatitis such as endoscopic retrograde cholangiopancreatography.

关键词： Acute pancreatitis drug-induced pancreatitis propofol systematic review

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临床实践指南应当包含治疗负担

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中国医院院长 2019年第3期15卷 22-22,24,26页

作者： Claudia C Dobler Nathan Harb Catherine A maguire Carol L Armour Courtney Coleman m hassan murad 邓璇(翻译) 莫云凌(校) Evidence Based Practice Center Robert D and Patricia E Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester MN USA Woolcock Institute of medical Research University of Sydney Sydney NSW Australia South Western Sydney Clinical School University of New South Wales NSW Sydney Australia

Claudia Dobler和同事们认为,指南中明确增加有关治疗负担的内容能够改善治疗决策。医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传... 详细信息

Claudia Dobler和同事们认为,指南中明确增加有关治疗负担的内容能够改善治疗决策。医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗作出明智的决定。

关键词：临床实践指南慢性阻塞性肺疾病肺康复急性加重治疗建议慢性病患者工作量

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Nanosecond pulse and dual-wavelength Q-switched 1.5 μm fiber laser using mAX phase Cr2TiAlC2 saturable absorber

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Optoelectronics Letters 2025年第1期21卷 7-12页

作者： Ahmed Shakir AL-HITI Hiba hassan Department of Electrical Engineering Faculty of Engineering University of Anbar Department of Laser and Optoelectronics Engineering University of Technology-Iraq

We demonstrated a new type of mAX phase material, chromium titanium aluminum carbide（Cr2TiAlC2） polymer film, to generate a passively Q-switched erbium-doped fiber laser（EDFL）. The film thickness was measured to be around 45 μm, which was fabricated using the embedding method with polyvinyl alcohol（PVA） polymer as hoster. The saturable absorber（SA） film demonstrates a dual-wavelength passively Q-switched EDFL which operates at 1 531 nm and 1 560.19 nm, respectively. The Q-switching pulse duration could be varied from 2.46 μs to 770 ns, while the repetition rate varied from 92.76 kHz to 106.6 kHz with an increasing input pumping range from 154 mW to 300 mW. The maximum output power and pulse energy of 15.05 mW and 141.18 nJ were obtained at the maximum input power of 300 mW, respectively.

关键词： Saturable absorbers

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GRADE指南：Ⅸ.证据质量升级

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中国循证医学杂志 2011年第12期11卷 1459-1463页

作者： Gordon H.Guyatt Andrew D.Oxman Shahnaz Sultan Paul Glasziou Elie A.Akl Pablo Alonso-Coello David Atkins Regina Kunz Jan Brozek Victor montori Roman Jaeschke David Rind Philipp Dahm Joerg meerpohl Gunn Vist Elise Berliner Susan Norris Yngve Falck-Ytter m.hassan murad Holger J.Schünemann 代表GRADE工作组李幼平杨晓妍李玲王应强机构不详

证据质量升级的最常见原因是效应量大。当方法学严谨的观察性研究表明风险至少降低或增加2倍时,GRADE建议考虑将证据质量升高1级;当风险至少降低或增加5倍时,考虑将证据质量升高2级。当存在剂量-反应关系,或所有合理的混杂、偏倚会降低... 详细信息

证据质量升级的最常见原因是效应量大。当方法学严谨的观察性研究表明风险至少降低或增加2倍时,GRADE建议考虑将证据质量升高1级;当风险至少降低或增加5倍时,考虑将证据质量升高2级。当存在剂量-反应关系,或所有合理的混杂、偏倚会降低明显的治疗效应,或混杂、偏倚使得结果无效为假效应时,系统评价作者和指南制定者也可考虑升高证据质量。其他考虑因素包括起效迅速、潜在的疾病(状态)趋势以及间接证据。

关键词： GRADE 指南证据等级观察性研究效应量大偏倚风险

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抑郁症的非药物治疗：系统性综述与证据图

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英国医学杂志中文版 2017年第11期20卷 660-667页

作者： Wigdan H Farah mouaz Alsawas maria mainou Fares Alahdab magdoleen H Farah Ahmed T Ahmed Essa A mohamed Jehad Almasri michael R Gionfriddo Ana Castaneda-Guarderas Khaled mohammed Zhen Wang Noor Asi Craig N Sawchuk mark D Williams Larry J Prokop m hassan murad Annie LeBlanc Evidence-Based Przctiee Center Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery Mayo Clinic Rochester Minnesota USA Knowledge and Evaluation Research Unit Mayo Clinic Rochester Minnesota USA Division of Preventive. Occupational and Aerospace medicine mayo Clinic Rochester Minnesota USA Integrated Behavioral Health Departmenl of Psychiatry and Psychology Mayo Clinic Rochester Minnesota USA mayo GraduateSchool Mayo ClinicRochesterMinnesota USA Center for PharmacyInnovation and Outcomes Geislnger Health System Forty Fort PennsylvaniaUSA Department of Emergency medicine Mayo ClinicRochesterMinnesota USA mayo Clinic

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，... 详细信息

背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述，回顾了随机对照试验（RCT），比较抑郁症非药物治疗的有效性和认知行为治疗（CBT）。对多个电子数据库在2016年2月之前发表的所有文献进行了检索，不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT，纳入了约2000名患者，进行了11种治疗，导出17项独立的头对头比较。通过标准化的量表评估，发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而，这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高，导致证据的质量只是低到中等，限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状，在轻度到重度抑郁症患者中，应当合并抗抑郁药物治疗，一同进行。对于非药物治疗的选择，应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。

关键词：抑郁症非药物治疗系统性综述证据图

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颈动脉粥样硬化疾病的处理美国血管外科学会临床实践指南

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中华脑血管病杂志（电子版） 2008年第6期2卷 371-377页

作者： Robert W.Hobson Ⅱ William C.mackey Enrico Ascher m.hassan murad Keith D.Calligaro Anthony J.Comerota Victor m.montori mark K.Eskandari Douglas W.massop Ruth L.Bush Brajesh K.Lal Bruce A.Perler 刘德志徐格林刘新峰 From the University of medicine and Dentistry of New Jersey Newark New England medical Center Boston maimonides medical Center Brooklyn mayo Clinic Rochester University of Pennsylvania School of medicine Philadelphia Jobst Vascular Center Toledo mayo Clinic College of medicine Rochester Northwestern University Feinberg School of medicine Chicago The Iowa Clinic Des Moines Texas A&m University Health Science Center College Station University of medicine and Dentistry of New Jersey Newark Johns Hopkins Hospital Baltimore 南京军区南京总医院神经内科 210002

美国血管外科学会(SVS)任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中,该委员会使用系统评价对当前最佳的证据进行了总结,采用GRADE标准对推荐意见的强度(强烈推荐为GRADEⅠ级,一般推荐为GRADE... 详细信息

美国血管外科学会(SVS)任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中,该委员会使用系统评价对当前最佳的证据进行了总结,采用GRADE标准对推荐意见的强度(强烈推荐为GRADEⅠ级,一般推荐为GRADEⅡ级)和证据的质量(高、中、低和极低)进行了分级。对于轻度颈动脉狭窄患者(有症状患者狭窄程度<50%和无症状患者狭窄程度<60%),推荐进行最佳的内科治疗而非血管重建术(Ⅰ级推荐,高质量证据)。对于有症状中到重度狭窄患者(狭窄程度≥50%),推荐行颈动脉内膜切除术(CEA)+最佳的内科治疗(Ⅰ级推荐,高质量证据)。对于围手术期风险高的有症状中到重度狭窄患者(狭窄程度≥50%),建议采用颈动脉支架置入术作为其替代治疗手段(Ⅱ级推荐,低质量证据)。对于中到重度狭窄的无症状患者(狭窄程度≥60%),只要围手术期风险较低,就推荐行CEA+内科治疗(Ⅰ级推荐,高质量证据)。对于中到重度狭窄的无症状患者(狭窄程度≥60%),不推荐行颈动脉支架置入术(Ⅰ级推荐,低质量证据)。颈动脉狭窄≥80%但存在CEA高危解剖学风险的患者可能是一个例外。

关键词：临床实践指南动脉粥样硬化疾病血管外科学会美国颈动脉支架置入术颈动脉内膜切除术颈动脉狭窄

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颈动脉粥样硬化疾病的处理美国血管外科学会临床实践指南

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国际脑血管病杂志 2008年第12期16卷 881-887页

作者： Robert W. Hobson, Ⅱ William C. mackey Enrico Ascher m. hassan murad Keith D. Calligaro Anthony J. Comerota Victor m. montori mark K. Eskandari Douglas W. massop Ruth L. Bush Brajesh K. Lal Bruce A. Perler 刘德志(译) 徐格林(译) 刘新峰(译) University of medicine and Dentistry of New Jersey Newark New England medical Center Boston maimonides medical Center Brooklyn mayo Clinic Rochester University of Pennsylvania school of medicine Philadelphia Jobst Vascular Center Toledo mayo Clinic College of medicine Rochester Northwestern University Feinberg School of medicine Chicago The Iowa Clinic Des Moines University of medicine and Dentistry of New Jersey Newark Texas A & m University Health Science Center College Station Johns Hopkins Hospital Baltimore 南京军区南京总医院神经内科 210002

美国血管外科学会（SVS）任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中，该委员会使用系统评价对当前最件的证据进行了总结，采用GRADE标准对推荐意见的强度（强烈推荐为GRADEI级，一般推荐为G... 详细信息

美国血管外科学会（SVS）任命了一个专家委员会制定颈动脉狭窄处理的循证临床指南。在制定临床实践推荐意见过程中，该委员会使用系统评价对当前最件的证据进行了总结，采用GRADE标准对推荐意见的强度（强烈推荐为GRADEI级，一般推荐为GRADEⅡ级）和证据的质量（高、中、低和极低）进行了分级。对于轻度颈动脉狭窄患者（有症状患者狭窄程度〈50％和无症状患者狭窄程度〈60％），推荐进行最佳的内科治疗而非血管重建术（I级推荐，高质量证据）。对于有症状中到重度狭窄患者（狭窄程度≥50％），推荐行颈动脉内膜切除术（CEA）＋最佳的内科治疗（I级推荐，高质量证据）。对于围手术期风险高的有症状巾到重度狭窄患者（狭窄程度≥50％），建议采用颈动脉支架置入术作为其替代治疗手段（Ⅱ级推荐，低质量证据）。对于中到重度狭窄的无症状患者（狭窄程度≥60％），只要围手术期风险较低，就推荐行CEA＋内科治疗（I级推荐，高质量证据）。对于中到重度狭窄的尢症状患者（狭窄稗度≥60％），不推荐行颈动脉支架置入术（I级推荐，低质量证据）。颈动脉狭窄≥80％但存在CEA高危解剖学风险的患者可能是一个例外。

关键词：临床实践指南动脉粥样硬化疾病血管外科学会美国颈动脉支架置入术颈动脉狭窄颈动脉内膜切除术

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Hepatitis C virus-associated pruritus: Etiopathogenesis and therapeutic strategies

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World Journal of Gastroenterology 2017年第5期23卷 743-750页

作者： Youssef Alhmada Denis Selimovic Fadi murad Sarah-Lilly hassan Youssef Haikel mossaad megahed matthias Hannig mohamed hassan Department of Pathology University of Mississippi Medical Center Graduate School of Dental medicine Depart-ment of Restorative DentistryDivision of Oral Health ScienceHokkaido University Clinic of Operative Dentistry Periodontology and Preventive DentistrySaarland University Department of Surgery Tulane University School of Medicine Clinic of Dermatology University Hospital of Aachen Institut National de la Santéet de la Recherchémédicale Department of Operative Dentistry and Endodontics Dental FacultyUniversity of Strasbourg

In addition to its contributing role in the development of chronic liver diseases, chronic hepatitis C virus (HCV) infection is associated with extrahepatic manifestations, particularly, cutaneous-based disorders including those with pruritus as a symptom. Pruritus is frequently associated with the development of chronic liver diseases such as cholestasis and chronic viral infection, and the accumulation of bile acids in patients’ sera and tissues as a consequence of liver damage is considered the main cause of pruritus. In addition to their role in dietary lipid absorption, bile acids can trigger the activation of specific receptors, such as the G protein-coupled bile acid receptor (GPBA/ TGR5). These types of receptors are known to play a crucial role in the modulation of the systemic actions of bile acids. TGR5 expression in primary sensory neurons triggers the activation of the transient receptor potential vanilloid 1 (TRPV1) leading to the induction of pruritus by an unknown mechanism. Although the pathologic phenomenon of pruritus is common, there is no uniformly effective therapy available. Understanding the mechanisms regulating the occurrence of pruritus together with the conduction of large-scale clinical and evidence-based studies, may help to create a standard treatment protocol. This review focuses on the etiopathogenesis and treatment strategies of pruritus associated with chronic HCV infection.

关键词： Hepatitis C virus Pruritus Cholestasis Autotoxin Lysophosphatidic acid PI3 kinase

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Study of magnetic and optical properties of Zn1-xTmxTe(Tm = mn,Fe,Co,Ni) diluted magnetic semiconductors：First principle approach

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Chinese Physics B 2017年第2期26卷 452-460页

作者： Q mahmood m hassan m A Faridi Department of Physics University of the Punjab Quaid-e-Azam Campus-54590 Lahore Pakistan Centre for High Energy Physics University of the Punjab Lahore Pakistan

We present structural,magnetic and optical characteristics of Zn_（1-x）Tm_xTe（Tm = mn,Fe,Co,Ni and x = 6.25%）,calculated through Wien2 k code,by using full potential linearized augmented plane wave（FP-LAPW） *** optimization of the crystal structures have been done to compare the ferromagnetic（Fm） and antiferromagnetic（AFm） ground state energies,to elucidate the ferromagnetic phase stability,which further has been verified through the formation and cohesive ***,the estimated Curie temperatures T_c have demonstrated above room temperature ferromagnetism（RTFm） in Zn_（1-x）Tm_xTe（Tm =mn,Fe,Co,Ni and x= 6.25%）.The calculated electronic properties have depicted that mn- and Co-doped ZnTe behave as ferromagnetic semiconductors,while half-metallic ferromagnetic behaviors are observed in Fe- and Ni-doped *** presence of ferromagnetism is also demonstrated to be due to both the p-d and s-d hybridizations between the host lattice cations and Tm *** calculated band gaps and static real dielectric constants have been observed to vary according to Penn＇s *** evaluated band gaps lie in near visible and ultraviolet regions,which make these materials suitable for various important device applications in optoelectronic and spintronic.

关键词： magnetic semiconductors density functional theory optical and dielectric properties electron density of states and band structure of crystalline solids

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