Acute pancreatitis associated with intravenous administration of propofol:evaluation of causality in a systematic review of the literature

作     者：Samir Haffar Ravinder Jeet Kaur Sushil Kumar Garg Joseph A.Hyder M.Hassan Murad Barham K.Abu Dayyeh Fateh Bazerbachi 

作者机构：Digestive Center for Diagnosis&Treatment29 Ayar StreetDamascusSyrian Arab Republic Division of Gastroenterology and HepatologyMayo Clinic200 First Street SWRochesterMN 55905USA Division of Anesthesiology and Perioperative MedicineMayo Clinic200 First Street SWRochesterMN 55905USA Division of Health Care Policy and ResearchMayo Clinic200 First Street SWRochesterMN 55905USA 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2019年第7卷第1期

页      面：13-23,I0001页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Acute pancreatitis drug-induced pancreatitis propofol systematic review 

摘      要：Acute pancreatitis(AP)associated with intravenous administration of propofol has been described with unknown causal *** therefore assessed this causality in a systematic *** databases were searched on 16 August 2017;studies were appraised and selected by two reviewers based on a priori *** causality was evaluated with the Naranjo scale and Badalov *** identified 18 studies from 11 countries with a total of 21 patients,and the majority had adequate methodological *** median age was 35 years(range,4–77)and 10(48%)were ***,propofol was administrated in 8 patients as sedative along with induction/maintenance of anesthesia in 13 patients;median dose was 200 mg,with intermediate latency(1–30 days)in 14(67%).Serum triglycerides were1000 mg/dL in four *** AP was observed in four patients(19%).AP recurrence occurred in one out of two patients who underwent *** related to AP was 3/21(14%).Propofol was the probable cause of AP according to the Naranjo scale in 19 patients(89%).Propofol-induced AP has a probable causal relation and evidence supports Badalov class *** is not the only mechanism by which propofol illicit ***-induced AP was severe in 19%of patients with a mortality rate related to AP of 14%.Future research is needed to delineate whether this risk is higher if combined with other procedures that portend inherent risk of pancreatitis such as endoscopic retrograde cholangiopancreatography.