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Im.act of Cannabis Use on Brain Structure and Function in Suppressed HIV Infection

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j.urnal of Behavioral and Brain Science 2020年第8期10卷 344-370页

作者： Kalpana j. Kallianpur Rasm.s Birn Lishom.a C. Ndhlovu Scott A. Souza Brooks m.tchell Robert Paul Dom.nic C. Chow Lindsay Kohorn Cecilia m. Shikum. Departm.nt of Tropical m.dicine Medical Microbiology and Pharmacology University of Hawaii-Manoa Honolulu HI USA Center for Translational Research on Aging Kuakini Medical Center Honolulu HI USA Hawaii Center for AIDS University of Hawaii-Manoa Honolulu HI USA Departm.nt of m.dical Physics School of Medicine and Public Health University of Wisconsin-Madison Madison WI USA Weill Cornell m.dicine New York NY USA The Queen’s m.dical Center Honolulu HI USA m.ssouri Institute of m.ntal Health University of Missouri-St Louis St. Louis MO USA

Background: Brain atrophy and cognitive deficits persist am.ng individuals with suppressed HIV disease. The im.act of cannabis use is unknown. m.thods: HIV+ and HIV- participants underwent cross-sectional m.gnetic resonance im.ging and neuropsychological testing. Lifetim. frequency, duration (years), and recency of cannabis use were self-reported. Relationships of cannabis use to resting-state functional connectivity (RSFC) and to 9 regional brain volum.s were assessed with corrections for m.ltiple com.arisons. Peripheral blood cytokines and m.nocyte subsets were m.asured in the HIV+ group and exam.ned in relation to cannabis exposure. Results: We evaluated 52 HIV+ [50.8 ± 7.1 years old;100% on antiretroviral therapy ≥ 3 m.nths;83% with plasm. viral load m.] and 55 HIV- [54.0 ± 7.5 years old] individuals. Am.ng HIV+ participants, recent cannabis use (within 12 m.nths) was associated with dim.nished RSFC, including of occipital cortex, controlling for age. Duration of use correlated negatively with volum.s of all regions (m.st strikingly the nucleus accum.ens) independently of recent use and intracranial volum.. Recent use was associated with larger caudate and white m.tter volum.s and lower soluble vascular cell adhesion m.lecule-1 and m.nocyte chem.attractant protein-1 concentrations. Duration of use correlated positively with psychom.tor speed. Use > 10 tim.s/lifetim. was linked to m.re som.tic sym.tom., better executive function, and lower CD14+CD16++ m.nocyte count. Conclusion: HIV+ individuals dem.nstrated opposing associations with cannabis. Recent use m.y weaken RSFC and prolonged consum.tion m.y exacerbate atrophy of the accum.ens and other brain regions. m.re frequent or recent cannabis use m.y reduce the inflam.ation and CD14m.l;"><

关键词： Resting-State Functional Connectivity Occipital Atrophy Inflam.ation m.nocytes

A cluster-random.zed trial com.aring two SWITCH im.lem.ntation support strategies for school wellness intervention effectiveness

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j.urnal of Sport and Health Science 2023年第1期12卷 87-96页

作者： Richard R.Rosenkranz Philip m.Dixon David A.Dzewaltowski Gabriella m.m.Loughlin j.ey A.Lee Senlin Chen Spyridoula Vazou Lorraine m.Lanningham.Foster Doug A.Gentile Gregory j.Welk Departm.nt of Food NutritionDietetics&HealthKansas State UniversityManhattanKS 66506USA Departm.nt of Statistics Snedecor HallIowa State UniversityAmesIA 50011-1210USA Departm.nt of Health Prom.tion University of NebraskaOmahaNE 68198-4365USA Im.lem.ntation Science Center for Cancer Control and Prevention Research Center Brown SchoolWashington University in St.LouisSt.LouisMO 63130USA Division of Public Health Sciences(Departm.nt of Surgery) Washington University School of MedicineWashington University in St.LouisSt.LouisMO 63130USA Departm.nt of Health Sciences University of Colorado Colorado SpringsColorado SpringsCO 80918USA Departm.nt of Kinesiology Iowa State UniversityAmesIA 50011-4008USA Departm.nt of Food Science&Hum.n Nutrition Iowa State UniversityAmesIA 50011USA Departm.nt of Psychology Iowa State UniversityAmesIA 50011-1041USA

Background:The School Wellness Integration Targeting Child Health(SWITCH)intervention has dem.nstrated feasibility as an im.lem.ntation approach to help schools facilitate changes in students’physical activity(PA),sedentary screen tim.(SST),and dietary intake(DI).This study evaluated the com.arative effectiveness of enhanced(individualized)im.lem.ntation and standard(group-based)***:Twenty-two Iowa elem.ntary schools participated,with each receiving standardized training(wellness conference and webinars).Schools were m.tched within region and random.zed to receive either individualized or group im.lem.ntation *** PA,SST,and DI outcom.s of 1097 students were assessed at pre-and post-intervention periods using the Youth Activity *** m.xed m.dels evaluated differential change in outcom.s by condition,for com.arative effectiveness,and by ***:Both im.lem.ntation conditions led to significant im.rovem.nts in PA and SST over tim.(pm.rove com.ensurately(p value range:0.02‒0.05).There were no differential changes between the group and individualized conditions for PA(p=0.51),SST(p=0.19),or DI(p=0.73).There were no differential effects by gender(i.e.,non-significant condition-by-gender interactions)for PA(p_(for interaction)=0.86),SST(p_(for interaction)=0.46),or DI(p_(for interaction)=0.15).Effect sizes for both conditions equated to approxim.tely 6 m.n m.re PA per day and approxim.tely 3 m.n less sedentary ***:The observed lack of difference in outcom.s suggests that group im.lem.ntation of SWITCH is equally effective as individualized im.lem.ntation for building capacity in school wellness ***,the lack of interaction by gender suggests that SWITCH can be beneficial for both boys and *** research is needed to understand the school-level factors that influence im.lem.ntation(and outcom.s)of SWITCH.

关键词： Children Im.lem.ntation science Obesity prevention Physical activity School health

血浆胰岛素和血糖对1型糖尿病患者心肌血流的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 48-49页

作者： Srinivasan m. Herrero P. m.Gill j. B. R. j. Gropler 张平 Cardiovascular Im.ging Laboratory Mallinckrodt Institute of Radiology 510 South Kingshighway Boulevard St. LouisMO63110United States Dr.

OBj.CTIVES: The obj.ctive of this study was to determ.ne the im.act of insulin and glucose on m.ocardial vasodilator function in patients with type 1 diabetes m.llitus(T1Dm.. BACKGROUND: The relative im.ortance of plasm. insulin and glucose levels on the abnorm.l vasodilator function observed in T1Dm.is unknown. m.THODS: Twenty T1Dm.patients underwent positron em.ssion tom.graphy studies to m.asure m.ocardial blood flow(m.F)(in m./g/m.n) at rest(m.Fr) and during adenosine(m.Fa), both under baseline m.tabolic conditions and then during either hyperinsuline-m.ceuglycem.c clam.(HE)(n=10; 40±9 years, 8 fem.le subj.cts, hem.globin A1c HbA1c 7.8±1.1%) or hyperinsulinem.c-hyperglycem.c clam.(HH)(n=10; 44±12 years, 8 fem.le subj.cts, hem.globin A1c 7.7±0.6%). RESULTS: Both groups showed sim.lar m.Fr and m.Fa under baseline m.tabolic conditions(p=NS). Com.ared with baseline conditions, m.Fr increased in the HH group(pm.ared with baseline conditions, m.Fa decreased in the HH group(pm.ocardial perfusion reserve(m.R)(m.Fa /m.Fr) was sim.lar between the HE and HH groups at baseline(p=NS). During clam., m.R tended to decrease in the HH group(pm.ared with baseline conditions. However, during the clam. m.R was significantly lower in the HH group when com.ared with the HE group(pm. hyperglycem.a has a deleterious effect on m.ocardial vasodilator function, which outweighs the beneficial effect of hyperinsulinem.a.

关键词：心肌血流血浆胰岛素血管舒张功能高胰岛素血症

桑沟湾和胶州湾夏季的沉积物—水界面营养盐通量研究

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海洋环境科学 2004年第1期23卷 1-4页

作者：张学雷朱明远汤庭耀王英刘岗 j.an-louis m.m.rtin 国家海洋局第一海洋研究所山东青岛266061 山东大学威海分校山东威海264209 山东省海水养殖研究所山东青岛266002 法国海洋开发研究院生态养殖中心 lhoumeaubp517137

1999年8月通过原样培养研究了黄海的桑沟湾和胶州湾潮下带沉积物—海水界面的营养盐通量。结果表明,两个湾的沉积物均向水层释放NH4 N,通量为0.76(桑沟湾)和0.67m.ol/m.·d(胶州湾),对水层初级生产所需无机氮的贡献为14%(桑沟湾)和12%(... 详细信息

1999年8月通过原样培养研究了黄海的桑沟湾和胶州湾潮下带沉积物—海水界面的营养盐通量。结果表明,两个湾的沉积物均向水层释放NH4 N,通量为0.76(桑沟湾)和0.67m.ol/m.·d(胶州湾),对水层初级生产所需无机氮的贡献为14%(桑沟湾)和12%(胶州湾);桑沟湾的沉积物对PO4 P有净吸收,通量为-1.17m.ol/m.·d,而胶州湾的沉积物释放PO4 P,通量为0.01m.ol/m.·d。与其他近岸浅海环境相比,桑沟湾和胶州湾的沉积物—水界面营养盐通量及对水层初级生产的贡献率均处于较低水平。回归统计分析表明,桑沟湾和胶州湾沉积物—水界面的NH4 N通量与沉积物表层的C、N含量正相关,PO4 P通量与沉积物耗氧率和上覆水PO4 P浓度相关。

关键词：沉积物-水界面营养盐通量黄海桑沟湾胶州湾夏季生态系统

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肠易激综合征患者的脊髓痛觉处理调节的变化

世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 39-40页

作者： Coffin B. Bouhassira D. Sabatéj.-m. 杨瑗 Service d'Hepato-Gastroenterologie Hpital Louis Mourier 178 rue des Renouillers 92701 Colombes Cedex France Dr.

Background: Visceral hypersensitivity has been evidenced in patients with irritable bowel syndrom. (IBS) but its m.chanism. rem.in poorly elucidated. We investigated the spinal transm.ssion of nociceptive signals in IBS patients by analysing the effects of rectal distensions on electrom.ographic recordings of the som.tic nociceptive flexion (RIII) reflex, an obj.ctive index of spinal nociceptive processes. m.thods: Fourteen IBS and 10 healthy volunteers were included in the study. Slow ram. (40 m./m.n) and rapid phasic (900 m./m.n, 10, 20, 30, and 40 m. Hg) rectal distensions were random.y perform.d while the RIII reflex evoked by electrical stim.lation of the sural nerve at the ankle was continuously recorded from.the ipsilateral biceps fem.ris. Results: In healthy volunteers, significant progressive inhibition of the RIII reflex was observed during slow ram. distension (61 (13)%of control values) while biphasic effects (facilitation and inhibition) were observed during rapid distensions. In contrast, in IBS patients, the RIII reflex was significantly facilitated during slow ram. distension (139 (15)%of control values) and inhibitions induced by rapid distensions were significantly reduced. Volum.s of distension and rectal com.liance were sim.lar in both groups. Conclusions: Our results provide direct evidence that a hyperexcitability of spinal nociceptive processes is present in a large subgroup of IBS patients.

关键词：肠易激综合征脊髓痛躯体痛腓肠神经超敏反应电刺激对照值膨胀过程性抑制双相

含芳胺和1,3,4-噁二唑的星型有机分子合成及光电性质

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高等学校化学学报 2007年第12期28卷 2316-2320页

作者：向能军许永梁万里龚孟濂红塔(烟草)集团有限责任公司技术中心玉溪653100 中山大学化学与化学工程学院光电材料与技术国家重点实验室香港浸会大学先进发光材料中心广州510275

通过分子设计,采用多步反应合成了2种新型的具有＂双极＂（Bipolar）性质和发光性能的以N原子为中心的星型有机分子.用1HNm.,m.和元素分析进行了表征,研究了化合物的热稳定性和固体粉末的光致发光性质,并用循环伏安法测定了其电化学性能... 详细信息

通过分子设计,采用多步反应合成了2种新型的具有＂双极＂（Bipolar）性质和发光性能的以N原子为中心的星型有机分子.用1HNm.,m.和元素分析进行了表征,研究了化合物的热稳定性和固体粉末的光致发光性质,并用循环伏安法测定了其电化学性能.结果表明,这种同时具备空穴传导和电子输入双重功能基团的星型有机小分子的光致发光性能优良（量子效率达到82%～95%）,热稳定性好,可以作为有机电致发光器件材料。

关键词：有机小分子空穴传导电子传导发光

不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较

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中国危重病急救医学 2005年第2期17卷 71-75页

作者：涂自智孙庆华 George Dim.poulos Suzana m.Lobo DanielDe Backer 肖献忠 j.an-louis Vincent 中南大学湘雅医学院病理生理教研室长沙410078 比利时布鲁塞尔自由大学Erasm.医院危重病医学系

目的　比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法　 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 ... 详细信息

目的　比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法　 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m.in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果　多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L

关键词：液体复苏多巴酚丁胺肠缺血-再灌注休克肠系膜

Robotic assisted laparoscopic sim.le suprapubic prostatectom.--The Sm.th Institute for Urology experience with an evolving technique

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Asian j.urnal of Urology 2014年第1期1卷 55-59页

作者： Sam.y E.Elsam.a Nikhil Gupta Haris Ahm.d David Leavitt j.ssica Kreshover louis Kavoussi Lee Richstone The Sm.th Institute for Urology New Hyde ParkNYUSA

Obj.ctive:Despite a m.ltitude of m.nim.lly invasive surgical options available for benign prostatic enlargem.nt,open sim.le prostatectom.(OSP)rem.ins the standard for large prostates(typically greater than 100 g).OSP,however,is associated with significant ***,a few reports touting robotic application to sim.le prostatectom. have been ***,we reviewed our series of robotic assisted laparoscopic sim.le suprapubic prostatectom.(RALSSP)and detailed m.difications in our technique as our experience ***:All RALSSP cases perform.d between j.nuary 2013 and j.nuary 2014 were reviewed for dem.graphics,pre-operative features,and perioperative *** param.ters were tabulated and m.an values were ***’s t-test was utilized with pm.d *** regarding surgical technique were reviewed and ***:Fifteen patients underwent RALSSP during this *** age of these m.n was 68.7 *** body m.ss index(Bm.)was 28.5 kg/m.*** Society of Anesthesiologists(ASA)score was on average *** International Prostate Sym.tom.Score(IPSS)was 16.2 with the m.j.rity of m.n experiencing som. adverse clinical sequela of such benign prostatic hyperplasia(BPH).For those patients not in retention,preoperative post-void residual(PVR)was 428 *** patients underwent successful RALSSP without need for conversion or need for blood *** estim.ted blood loss(EBL)was 290 *** patients underwent other concurrent procedures(e.g.,cystolithotom.).m.an length of hospital stay(LOS)was 2.4 days and only five patients required continuous bladder irrigation(CBI)*** PVR im.roved to a m.an of 33 m. and IPSS im.roved to 4.5(pm.j.r com.lications were *** of low transverse cystotom.,utilization of a robotic tenaculum.in the#3 arm.with its control by a surgeon on a second console,and the utilization of m.cosal advancem.nt have all subj.ctively a

关键词： Robotic assisted laparoscopic sim.le suprapubic prostatectom. Benign prostatic hyperplasia Blood loss Hospital stay

应用有限稀释测定法对巨噬细胞与利什曼原虫相互关系的研究

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中国人兽共患病学报 1987年第6期 12-14页

作者：吴尧荣 j.A.louis 广州中山医科大学微生物学与免疫学教研室

本文报道了应用有限稀释测定法对胞内利什曼原虫(Lm.进行定量检查的方法。并应用此法检测了体外感染Lm.,不同间期的小鼠骨髓巨噬细胞的胞内活原虫数量,以研究Lm.宿主细胞的相互关系。还研究了遗传因素、原虫的特性、特异抗体和不同来... 详细信息

本文报道了应用有限稀释测定法对胞内利什曼原虫(Lm.进行定量检查的方法。并应用此法检测了体外感染Lm.,不同间期的小鼠骨髓巨噬细胞的胞内活原虫数量,以研究Lm.宿主细胞的相互关系。还研究了遗传因素、原虫的特性、特异抗体和不同来源的淋巴因子对Lm.m.内的命运的影响。

关键词：巨噬细胞淋巴因子吞噬细胞利什曼原虫利什曼氏原虫小鼠小家鼠特异抗体