Exploring Sequence Space to Design Controllable G-Quadruplex Topology Switches

作     者：Jielin Chen Mingpan Cheng Petr Stadlbauer JiříŠponer Jean-Louis Mergny Huangxian Ju Jun Zhou 

作者机构：State Key Laboratory of Analytical Chemistry for Life ScienceSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023 Institute of Biophysics of the Czech Academy of SciencesKrálovopolská135Brno 61265 Regional Centre of Advanced Technologies and MaterialsCzech Advanced Technology and Research Institute(CATRIN)Palacky University OlomoucŠlechtitelů241/27Olomouc–Holice 78371 Laboratoire d’Optique et BiosciencesEcole PolytechniqueCNRSINSERMInstitut Polytechnique de ParisPalaiseau 91128 

出 版 物：《CCS Chemistry》 (中国化学会会刊（英文）)

年 卷 期：2022年第4卷第9期

页      面：3036-3050页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070302[理学-分析化学] 0703[理学-化学] 

基　　金：supported in part by the National Natural Science Foundation of China(nos.21977045 and 21635005) the Fundamental Research Funds for the Central Universities(no.02051430210) the funds of Nanjing University(no.020514912216) project 21-23718S of the Czech Science Foundation(P.S.and J.S.) the project SYMBIT reg.number:CZ.02.1.01/0.0/0.0/15_003/0000477 financed by the ERDF(J.S.and J.-L.M.) 

主　　题：G-quadruplex G-quadruplex topology Gswitch sequence composition structural versatility 

摘      要：As nonclassical nucleic acid structures,G-quadruplexes(G4s)not only play important roles in gene regulation and stability maintenance,but are also widely used in *** diversity is one of the main factors explaining the popularity of G4s,but a comprehensive and integrated study of different factors determining G4 structural versatility is currently lacking.