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Regenerative Biomaterials 2021年第1期8卷 112-123页

作者： long-mei zhao mei Gong Rui Wang Qi-Juan Yuan Yi Zhang Jin-Kui Pi Xiu-He Lv Yan Xie Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyKeyuan Road 4Gaopeng Street ChengduSichuan 610041China Research Core Facility West China HospitalSichuan UniversityKeyuan Road 4Gaopeng StreetChengduSichuan 610041China Department of Gastroenterology West China HospitalSichuan UniversityNo.37 Guo Xue XiangChengduSichuan 610041China

Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side ***-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD *** this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine ***/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in ***,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in *** a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer ***/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight *** findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.

关键词： ESD-induced ulc er small inte stinal submucosa polyurethane bio-a dhesion pH-sensitive

PACLITAXEL PLUS CARBOPLATIN FOR WOMEN WITH ADVANCED BREAST CANCER

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Chinese Medical Sciences Journal 2007年第2期22卷 93-97页

作者： Ju Liu Qing Li Pin Zhang Jia-yu Wang long-mei zhao Bing-he Xu Department of Medical Oncology Cancer Hospital ＆ Institute Chinese Academy of Medical Sciences ＆Peking Union Medical College Beijing 100021

Objective To evaluate the efficacy and safety of combination chemotherapy with paclitaxel and carboplatin for advanced breast cancer (ABC). Methods From January 2001 to March 2006, 45 patients with ABC were treated with combination chemotherapy of paclitaxel and carboplatin. Patients received infusion of paclitaxel 175 mg/m2 on day 1 every 3 weeks or 75 mg/m2 on day 1, 8, 15 every 4 weeks. Carboplatin was administrated on day 2 with a dose of area under the time-concentration curve (AUC) being 5. Results The median number of cycles was 3 (range, 2-6). The overall response rate was 62.2%. Median time to progression was 7.0 months (95%CI:5.1-8.9). Median overall survival was 29.0 months (95%CI: 20.1-37.9). One year survival rate was 73.3%. Response rate for first line and second line treatment were 62.1% and 62.5%, respectively. No significant difference in response existed between visceral metastasis and soft tissue metastasis. The main side effects included nausea/vomiting, neurotoxicity, and hematologic toxicities. Grade Ⅲ to Ⅳ adverse events included nausea/vomiting in 2 cases (4.4%), leukopenia in 17 cases (37.8%), and alopecia in 6 cases (13.3%). Conclusion Combination of paclitaxel and carboplatin is active in treatment of ABC with an acceptable toxicity profile.

关键词： breast neoplasms paclitaxel carboplatin

Promotion of right ventricular outflow tract reconstruction using a novel cardiac patch incorporated with hypoxia-pretreated urine-derived stem cells

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Bioactive Materials 2022年第8期7卷 206-218页

作者： long-mei zhao long Wang Wen-Qian Zhang Rui Wang Xiu-Zhen Zhang Xiong-Xin Lei Yan Liang Yu-Ting Song Qing-Yi Zhang Ke Lin Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Cardiovascular Surgery West China HospitalSichuan UniversityChengduSichuan610041China Department of Cardiovascular Surgery Shandong Provincial HospitalShandong First Medical UniversityJinanShandong250021China Research Core Facility West China HospitalSichuan UniversityChengduSichuan610041China

Approximately 25%of patients with congenital heart disease require implantation of patches to ***,most of the currently available patches are made of inert materials with unmatched electrical conductivity and mechanical properties,which may lead to an increased risk for arrhythmia and heart *** this study,we have developed a novel Polyurethane/Small intestinal submucosa patch(PSP)with mechanical and electrical properties similar to those of the native myocardial tissue,and assessed its feasibility for the reconstruction of right ventricular outflow tract.A right ventricular outflow tract reconstruction model was constructed in 40 *** with commercially available bovine pericardium patch,the PSP patch has shown better histocompatibility and biodegradability,in addition with significantly improved cardiac *** tackle the significant fibrosis and relatively poor vascularization during tissue remodeling,we have further developed a bioactive patch by incorporating the PSP composites with urine-derived stem cells(USCs)which were pretreated with *** results showed that the hypoxia-pretreated bioactive patch could significantly inhibit fibrosis and promote vascularization and muscularization,resulting in better right heart *** findings suggested that the PSP patch combined with hypoxia-pretreated USCs may provide a better strategy for the treatment of congenital heart disease.

关键词： Congenital heart disease Polypyrrole Polyurethane/small intestinal submucosa Hypoxia Urine-derived stem cells

Multifunctional two-component in-situ hydrogel for esophageal submucosal dissection for mucosa uplift,postoperative wound closure and rapid healing

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Bioactive Materials 2023年第9期27卷 461-473页

作者： Xiong-Xin Lei Juan-Juan Hu Chen-Yu Zou Yan-Lin Jiang long-mei zhao Xiu-Zhen Zhang Ya-Xing Li An-Ni Peng Yu-Ting Song Li-Ping Huang Jesse Li-Ling Hui-Qi Xie Department of Orthopedic Surgery and Orthopedic Research Institute Laboratory of Stem Cell and Tissue EngineeringState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Otolaryngology Head and Neck SurgeryWest China HospitalSichuan UniversityChengduSichuan610041China Institute of Biomedical Engineering and Informatics Ilmenau University of TechnologyGustav-Kirchh Off Str.298693IlmenauGermany Department of Medical Genetics West China Second HospitalSichuan UniversityChengduSichuan610041China

Endoscopic submucosal dissection (ESD) for gastrointestinal tumors and premalignant lesions needs submucosal fluid cushion (SFC) for mucosal uplift before dissection, and wound care including wound closure and rapid healing postoperatively. Current SFC materials as well as materials and/or methods for post-ESD wound care have single treatment effect and hold corresponding drawbacks, such as easy dispersion, short duration, weak hemostasis and insufficient repair function. Thus, designing materials that can serve as both SFC materials and wound care is highly desired, and remains a challenge. Herein, we report a two-component in-situ hydrogel prepared from maleimide-based oxidized sodium alginate and sulfhydryl carboxymethyl-chitosan, which gelated mainly based on "click" chemistry and Schiff base reaction. The hydrogels showed short gelation time, outstanding tissue adhesion, favorable hemostatic properties, and good biocompatibility. A rat subcutaneous ultrasound model confirmed the ability of suitable mucosal uplift height and durable maintenance time of AM solution. The in vivo/in vitro rabbit liver hemorrhage model demonstrated the effects of hydrogel in rapid hemostasis and prevention of delayed bleeding. The canine esophageal ESD model corroborated that the in-situ hydrogel provided good mucosal uplift and wound closure effects, and significantly accelerated wound healing with accelerating re-epithelization and ECM remodeling post-ESD. The two-component in-situ hydrogels exhibited great potential in gastrointestinal tract ESD.

关键词： Hydrogel Endoscopic submucosal dissection Mucosa uplift Tissue sealant Wound healing

Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

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Bioactive Materials 2022年第8期7卷 443-455页

作者： Yu-Ting Song Yan-Qing Li Mao-Xuan Tian Jun-Gen Hu Xiu-Ru Zhang Peng-Cheng Liu Xiu-Zhen Zhang Qing-Yi Zhang Li Zhou long-mei zhao Jesse Li-Ling Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Aesthetic Surgery The People’s Hospital of PengzhouChengduSichuan611930China Surgery of Spine and Spinal Cord Henan Provincial People’s HospitalZhengzhouHenan450000China Department of Burn and Plastic Surgery West China HospitalSichuan UniversityChengduSichuan610041China Research Core Facility of West China Hospital Sichuan UniversityChengduSichuan610041China Department of Medical Genetics and Prenatal Diagnosis West China Second HospitalSichuan UniversityChengduSichuan610041China

The need for bladder reconstruction and side effects of cystoplasty have spawned the demand for the development of alternative material *** such as submucosa of small intestine(SIS)have been widely used as patches for bladder repair,but the outcomes are not fully *** capture stem cells in situ has been considered as a promising strategy to speed up the process of re-cellularization and *** this study,we have developed an anti-CD29 antibody-conjugated SIS scaffold(AC-SIS)which is capable of specifically capturing urine-derived stem cells(USCs)in situ for tissue repair and *** scaffold has exhibited effective capture capacity and sound *** vivo experiment proved that the AC-SIS scaffold could promote rapid endothelium healing and smooth muscle *** endogenous stem cell capturing scaffolds has thereby provided a new revenue for developing effective and safer bladder patches.

关键词： Regenerative medicine Bladder tissue engineering Scaffold Antibody-conjugated

Procyanidins-crosslinked small intestine submucosa: A bladder patch promotes smooth muscle regeneration and bladder function restoration in a rabbit model

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Bioactive Materials 2021年第6期6卷 1827-1838页

作者： Xiu-Zhen Zhang Yan-Lin Jiang Jun-Gen Hu long-mei zhao Qiu-Zhu Chen Yan Liang Yi Zhang Xiong-Xin Lei Rui Wang Yi Lei Qing-Yi Zhang Jesse Li-Ling Hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengduSichuanChina Research Core Facility of West China Hospital Sichuan UniversityChengduSichuanChina

Currently the standard surgical treatment for bladder defects is augmentation cystoplasty with autologous tissues,which has many side *** such as small intestine submucosa(SIS)can provide an alternative scaffold for the repair as bladder *** studies have shown that SIS could enhance the capacity and compliance of the bladder,but its application is hindered by issues like limited smooth muscle regeneration and stone formation since the fast degradation and poor mechanical properties of the ***(PC),a natural bio-crosslinking agent,has shown anti-calcification,anti-inflammatory and anti-oxidation *** importantly,PC and SIS can crosslink through hydrogen bonds,which may endow the material with enhanced mechanical property and stabilized *** this study,various concentrations of PC-crosslinked SIS(PC-SIS)were prepared to repair the full-thickness bladder defects,with an aim to reduce complications and enhance bladder *** vitro assays showed that the crosslinking has conferred the biomaterial with superior mechanical property and anti-calcification property,ability to promote smooth muscle cell adhesion and upregulate functional genes *** a rabbit model with bladder defects,we demonstrated that the PC-SIS scaffold can rapidly promote in situ tissue regrowth and regeneration,in particular smooth muscle remodeling and improvement of urinary *** PC-SIS scaffold has therefore provided a promising material for the reconstruction of a functional bladder.

关键词： Bladder reconstruction Small intestinal submucosa Procyanidins Bio-crosslinking Smooth muscle regeneration

Application of metabolomics in urolithiasis:the discovery and usage of succinate

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Signal Transduction and Targeted Therapy 2023年第2期8卷 771-783页

作者： Xiu-zhen Zhang Xiong-xin Lei Yan-lin Jiang long-mei zhao Chen-yu Zou Yun-jin Bai Ya-xing Li Rui Wang Qian-jin Li Qiu-zhu Chen Ming-hui Fan Yu-ting Song Wen-qian Zhang Yi Zhang Jesse Li-Ling Hui-qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteDepartment of OrthopedicsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengduSichuan 610041China Research Core Facility of West China Hospital Sichuan UniversityChengduSichuan 610041China Department of Medical Genetics West China Second University HospitalChengduSichuan 610041China

Urinary stone is conceptualized as a chronic metabolic disorder punctuated by symptomatic stone *** has been shown that the occurrence of calcium oxalate monohydrate(COM)during stone formation is regulated by crystal growth *** crystallization inhibitors have been recognized as a therapeutic modality for decades,limited progress has been made in the discovery of effective modifiers to intervene with stone *** this study,we have used metabolomics technologies,a powerful approach to identify biomarkers by screening the urine components of the dynamic progression in a bladder stone *** in-depth mining and analysis of metabolomics data,we have screened five differential *** density functional theory studies and bulk crystallization,we found that three of them(salicyluric,gentisic acid and succinate)could effectively inhibit nucleation in *** thereby assessed the impact of the inhibitors with an EG-induced rat model for kidney ***,succinate,a key player in the tricarboxylic acid cycle,could decrease kidney calcium deposition and injury in the *** analysis further showed that the protective effect of succinate was mainly through anti-inflammation,inhibition of cell adhesion and osteogenic *** findings indicated that succinate may provide a new therapeutic option for urinary stones.

关键词： crystallization thereby protective

Recent advances of metal vacancies in energy and environmental catalysis:Synthesis,characterization,and roles

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Green Energy & Environment 2025年第1期10卷 84-108页

作者： long Sun Shunzheng zhao Sirui Gao Ronghui Zhu Yiran Tan Xiaolong Tang Honghong Yi School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants Beijing100083China

With the ongoing depletion of fossil fuels,energy and environmental issues have become increasingly critical,necessitating the search for effective ***,being one of the hallmarks of modern industry,offers a promising avenue for ***,the question of how to significantly enhance the performance of catalysts has gradually drawn the attention of *** engineering,a commonly employed and effective approach to improve catalyst activity,has become a significant research focus in the catalysis field in recent *** vacancies have received extensive attention due to their simple ***,exploration of metal vacancies has remained stagnant for a considerable period,resulting in a scarcity of comprehensive reviews on this ***,based on the latest research findings,this paper summarizes and consolidates the construction strategies for metal vacancies,characterization techniques,and their roles in typical energy and environmental catalytic ***,it outlines potential challenges in the future,aiming to provide valuable references for researchers interested in investigating metal vacancies.

关键词： Metal vacancies Catalysis Construction strategies Characterization techniques Roles

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： Yu-Jing Weng zhao-Ying Ding Ying-Chao Li Yuan-Feng Wu Yuan-Yang Xu Rui Chen Xiao-Lei zhao Hai-Yong Wang Da-Lei Zhang Yu-long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten