Accelerating ESD-induced gastric ulcer healing using a pH-responsive polyurethane/small intestinal submucosa hydrogel delivered by endoscopic catheter
作者机构：Laboratory of Stem Cell and Tissue EngineeringOrthopedic Research InstituteState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyKeyuan Road 4Gaopeng Street ChengduSichuan 610041China Research Core FacilityWest China HospitalSichuan UniversityKeyuan Road 4Gaopeng StreetChengduSichuan 610041China Department of GastroenterologyWest China HospitalSichuan UniversityNo.37 Guo Xue XiangChengduSichuan 610041China
出 版 物：《Regenerative Biomaterials》 (再生生物材料（英文版）)
年 卷 期：2021年第8卷第1期
页 面：112-123页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by The National Key R&D Program of China(2017YFC1104702) Sichuan Science and Technology Program(2019JDRC0020) the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC18002)
主 题：ESD-induced ulc er small inte stinal submucosa polyurethane bio-a dhesion pH-sensitive
摘 要：Endoscopic submucosal dissection(ESD)is the standard treatment for early-stage gastric cancer,but the large post-operative ulcers caused by ESD often lead to serious side ***-ESD mu-cosal repair materials provide a new option for the treatment of post-ESD *** this study,we developed a polyurethane/small intestinal submucosa(PU/SIS)hydrogel and investigated its effi-cacy for accelerating ESD-induced ulcer healing in a canine ***/SIS hydrogel possessed great biocompatibility and distinctive pH-sensitive swelling properties and protected GES-1 cells from acid attack through forming a dense film in acidic conditions in ***,PU/SIS gels present a strong bio-adhesion to gastric tissues under acidic conditions,thus ensuring the reten-tion time of PU/SIS gels in *** a canine model,PU/SIS hydrogel was easily delivered via endoscopy and adhered to the ulcer ***/SIS hydrogel accelerated gastric ulcer healing at an early stage with more epithelium regeneration and slight *** findings reveal PU/SIS hydrogel is a promising and attractive candidate for ESD-induced ulcer repair.
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