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Chitosan/Sodium Alginate Multilayer ph-sensitive Films Based on Layer-by-Layer Self-Assembly for Intelligent Packaging

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Journal of Renewable Materials 2024年第2期12卷 215-233页

作者： Mingxuan He Yahui Zheng Jiaming Shen Jiawei Shi Yongzheng Zhang Yinghong Xiao Jianfei Che Key Laboratory of Soft Chemistry and FunctionalMaterials Nanjing University of Science and TechnologyNanjing210094China Collaborative Innovation Center of Biomedical Functional Materials Nanjing Normal UniversityNanjing210046China

The abuse of plastic food packaging has brought about severe white pollution issues around the world.Developing green and sustainable biomass packaging is an effective way to solve this problem.Hence,a chitosan/sodium alginate-based multilayer film is fabricated via a layer-by-layer(LBL)self-assembly method.With the help of superior interaction between the layers,the multilayer film possesses excellent mechanical properties(with a tensile strength of 50 MPa).Besides,the film displays outstanding water retention property(blocking moisture of 97.56%)and ultraviolet blocking property.Anthocyanin is introduced into the film to detect the food quality since it is one natural plant polyphenol that is sensitive to the ph changes ranging from 1 to 13 in food when spoilage occurs.It is noted that the film is also bacteriostatic which is desired for food packaging.This study describes a simple technique for the development of advanced multifunctional and fully biodegradable food packaging film and it is a sustainable alternative to plastic packaging.

关键词： Chitosan alginate layer-by-layer self-assembly ph-sensitive multilayer films

Preparation and functional study of ph-sensitive amorphous calcium phosphate nanocarriers

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Chinese Journal of Chemical Engineering 2022年第8期35卷 244-252页

作者： Baolong Niu Min Li Jianhong Jia Lixuan Ren Xin Gang Bin Nie Yanying Fan Xiaojie Lian Wenfeng Li College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Taiyuan University of TechnologyTaiyuan 030024China Department of Biomedical Engineering Research Center for Nano-biomaterials&Regenerative MedicineCollege of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Material Strength&Structural Impact Institute of Biomedical EngineeringTaiyuan University of TechnologyTaiyuan 030024China School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 030001China

Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with ph-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.

关键词： Hyaluronic acid Amorphous calcium phosphate Fluorescent carbon nanoparticles ph-sensitive Tumor targeting

Tribological behavior of thermal- and ph-sensitive microgels under steel/CoCrMo alloy contacts

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Friction 2023年第4期11卷 602-616页

作者： Kequn SUN Yuanhua HU Yinghui DONG Lulu YAO Ruhong SONG Yufu XU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

The tribological behavior of 316L stainless steel/CoCrMo alloy contacts under aqueous lubrication was investigated in this work.Three types of microgels including poly(N-isopropylacrylamide)(PNIPAM),polyacrylic acid(PAA),and poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA)were prepared and used as lubricant additives in aqueous solutions.Tribological tests were conducted using a ball-on-disk reciprocating tribometer,over a range of temperatures,ph,and concentrations of the microgels.The PNIPAM-co-PAA microgels were proven to have excellent anti-friction and anti-wear properties,depending on the temperature and ph values of the solutions.The maximum friction coefficient coincided with the lower critical solution temperature of the PNIPAM-co-PAA microgels at 32°C.At the same time,the friction coefficient increased with the increase in ph value of the lubricant solution with the PNIPAM-co-PAA microgels.The unique thermal-and ph-sensitive properties of the PNIPAM-co-PAA microgels provided a new strategy for controlling the friction and wear of steel/CoCrMo alloy contacts under aqueous lubrication.

关键词： poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA) microgel aqueous lubrication thermal-sensitive ph-sensitive

Fabrication of Mesoporous SiO_(2)@CaSiO_(3) Hollow Spheres as Carriers for ph-sensitive Drug Delivery

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Chemical Research in Chinese Universities 2022年第4期38卷 999-1004页

作者： YUAN Mingwei SHI Shunli LUO Yanping YU Ying WANG Shuhua CHEN Chao Key Laboratory of Jiangxi Province for Environment and Energy Catalysis College of ChemistryNanchang UniversityNanchang330031P.R.China

Hollow mesoporous silica(HM-SiO_(2))was prepared by the improved stober method.On this basis,HM-SiO_(2) was dispersed in an alkaline solution for surface etching.Meanwhile,calcium source was introduced to combine with SiO_(3)^(2−) on the surface to form a CaSiO_(3) shell layer and an unprecedent SiO_(2)@CaSiO_(3) sphere with a hollow double-shell structure was obtained.The as-synthesized SiO_(2)@CaSiO_(3) was characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),N_(2)-BET,IR and UV-Vis techniques,and its sustained release capacity of doxorubicin(DOX)loading was investigated.The drug loading capacity can be achieved to 0.692 mg DOX/mg SiO_(2)@CaSiO_(3),exhibiting ph-responsivity under low ph conditions.

关键词： Hollow nano-sphere SiO_(2)@CaSiO_(3) Drug delivery ph-sensitive

Iron-based and BRD_(4)-downregulated strategy for amplified ferroptosis based on ph-sensitive/NIR-Ⅱ-boosted nano-matchbox

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Acta pharmaceutica Sinica B 2023年第2期13卷 863-878页

作者： Lujing Geng Tong Lu Huaqing Jing Yue Zhou Xiaoyang Liang Jiao Li Nan Li Tianjin Key Laboratory of Drug Delivery&High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China School of Precision Instruments and Optoelectronics Engineering Tianjin UniversityTianjin 300072China

Ferroptosis(FPT),a novel form of programmed cell death,is characterized by overwhelming iron/reactive oxygen species(ROS)-dependent accumulation of lipid peroxidation(LPO).However,the insufficiency of endogenous iron and ROS level limited the FPT therapeutic efficacy to a large extent.To overcome this obstacle,the bromodomain-containing protein 4(BRD_(4))-inhibitor(+)-JQ1(JQ1)and iron-supplement ferric ammonium citrate(FAC)-loaded gold nanorods(GNRs)are encapsulated into the zeolitic imidazolate framework-8(ZIF-8)to form matchbox-like GNRs@JF/ZIF-8 for the amplified FPT therapy.The existence of matchbox(ZIF-8)is stable in physiologically neutral conditions but degradable in acidic environment,which could prevent the loaded agents from prematurely reacting.Moreover,GNRs as the drug-carriers induce the photothermal therapy(PTT)effect under the irradiation of near-infraredⅡ(NIR-Ⅱ)light owing to the absorption by localized surface plasmon resonance(LSPR),while the hyperthermia also boosts the JQ1 and FAC releasing in the tumor microenvironment(TME).On one hand,the FAC-induced Fenton/Fenton-like reactions in TME can simultaneously generate iron(Fe^(3+)/Fe^(2+))and ROS to initiate the FPT treatment by LPO elevation.On the other hand,JQ1 as a small molecule inhibitor of BRD_(4)protein can amplify FPT through downregulating the expression of glutathione peroxidase 4(GPX4),thus inhibiting the ROS elimination and leading to the LPO accumulation.Both in vitro and in vivo studies reveal that this p H-sensitive nano-matchbox achieves obvious suppression of tumor growth with good biosafety and biocompatibility.As a result,our study points out a PTT combined iron-based/BRD_(4)-downregulated strategy for amplified ferrotherapy which also opens the door of future exploitation of ferrotherapy systems.

关键词： BDR_(4)protein Ferroptosis photothermal therapy ph-sensitive NIR-Ⅱlight ZIF-8 Fenton reactions Nano-matchbox

Encapsulating maytansinoid in ph-sensitive nanocarriers:The importance of using extremely potent cytotoxic agents and fast release for nanomedicine to achieve tumor elimination

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Nano Research 2019年第8期12卷 1959-1966页

作者： Bo Dai Xingyu Wu Christopher J. Butch Jianquan Wang Ziyang Wang Yisheng Wang Shuming Nie Qian Lu Yiqing Wang Yitao Ding Drum Tower Clinical Medical College Nanjing Medical UniversityNanjing 210008China Department of Biomedical Engineering College of Engineering and Applied SciencesNanjing UniversityNanjing 210008China Department of Biomedical Engineering University of Illinois at Urbana-ChampaignIllinois 61801USA

The clinical translation of nanomedicine is hindered by the low delivery efficiency, and consequently drug concentration in tumor sites falls short of the therapeutic effective range which leads to poor clinical outcomes. One important lesson learned from the development of antibody-drug-conjugates (ADCs) is that to achieve significant clinical benefits, extremely potent cytotoxic agents and cleavable linkers should be used. By encapsulating maytansinoid, AP3, which is 100-1,000 times more potent than most conventional small molecule anticancer drugs, in ph-sensitive acetalated dextran-polyethylene glycol (PEG)(ADP) nanocarriers, even with only 1% drug loading, we were able to eradicate tumors in 50% of tested animals with negligible side effects, while free AP3 only showed marginal efficacy and severe liver damages. This study suggests that besides improving the low efficiency of nano-delivery systems, the potency of drug to be delivered is also critical to the clinical outcomes of nanomedicine. Our results also showed that ADP nanoparticles (NPs) were able to expand the narrow therapeutic window of maytansinoids in a similar manner to the ADCs.

关键词： nanomedicine drug delivery maytansinoid extremely potent drug ph-sensitive nanocarrier

ph-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy

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Acta pharmaceutica Sinica B 2021年第2期11卷 520-533页

作者： Zhiming Zhangy Chenlu Huangy Li Zhang Qing Guo Yu Qin Fan Fan Boxuan Li Bao Xiao Dunwan Zhu Linhua Zhang Tianjin Key Laboratory of Biomedical Materials Key Laboratory of Biomaterials and Nanotechnology for Cancer ImmunotherapyInstitute of Biomedical EngineeringChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300192China

Chemotherapy has been a major option in clinic treatment of malignant tumors.However,single chemotherapy faces some drawbacks,such as multidrug resistance,severe side effects,which hinder its clinic application in tumor treatment.Multifunctional nanoparticles loading with chemotherapeutic agent and photosensitizer could be a promising way to efficiently conduct tumor combination therapy.In the current study,a novel ph-sensitive and bubble-generating mesoporous silica-based drug delivery system(denoted as M(a)D@PI-PEG-RGD)was constructed.Ammonium bicarbonate(NH4 HCO3;abc)and chemotherapeutic agent doxorubicin(DOX)were loaded into the pores of mesoporous silica.Indocyanine green(ICG)as a photothermal and photodynamic agent was loaded onto the polydopamine(PDA)layer surface.The synthesized nanoparticles displayed a narrow polydispersity(PDI)and small particle size as characterized through dynamic light scattering-autosizer analysis.The nanoparticles also showed high targeting efficacy through RGD modification as indicated by cellular uptake and animal studies.DOX release analysis confirmed that the nanoparticles were ph-dependent and that NH4 HCO3 accelerated drug release.At the same time,the nanoparticles had obvious photothermal and photodynamic effects performed by ICG which restrained tumor growth remarkably.In summary,the multifunctional nanoparticles presented a promising system for combination therapy.

关键词： Mesoporous silica ph-sensitive Bubble-generating Targeting modification Combination therapy

Linear-like polypeptide-based micelle with ph-sensitive detachable PEG to deliver dimeric camptothecin for cancer therapy

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Asian Journal of pharmaceutical Sciences 2023年第1期18卷 97-107页

作者： Ka Hong Wong Zhaopei Guo Di Jiang Xingzhi Zhou Lizhu Lin Denggao Zhao Meiwan Chen State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 999078China The First Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou 510407China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen 529020China

Nano drug delivery systems have made significant progress in delivering anticancer drugs camptothecin(CPT).However,many challenges for CPT delivery remain,including low drug loading efficiency,premature drug leakage,and poor cellular internalization.Herein,we report a novel dual-sensitive polypeptide-based micelle with remarkably high drug loading of CPT for cancer therapy.This self-assembled micelle possesses the following essential components for CPT:(1)ph-sensitive PEG(OHC-PEG-CHO)for prolonging blood circulation and allowing biocompatibility by shielding the cationic micelles,which can be detached under the tumor acidic microenvironment and facilitates the cellular uptake;(2)polypeptide polylysine-polyphenylalanine(PKF)synthesized via ring-opening polymerization for micelle formation and CPT analogue loading;(3)dimeric CPT(DCPT)with redox-sensitive linker for increasing CPT loading and ensuring drug release at tumor sites.Interestingly,the linear-like morphology of PEG-PKF/DCPT micelles was able to enhance their cellular internalization when compared with the spherical blank PKF micelles.Also,the anticancer efficacy of DCPT against lung cancer cells was significantly improved by the micelle formation.In conclusion,this work provides a promising strategy facilitating the safety and effective application of CPT in cancer therapy.

关键词： Dimeric camptothecin ph-sensitive Redox-responsive Cancer therapy Self-assembled micelle

NOVEL ph-sensitive DRUG DELIVERY SYSTEM BASED ON NATURAL POLYSACCHARIDE FOR DOXORUBICIN RELEASE

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Chinese Journal of Polymer Science 2008年第3期26卷 369-374页

作者：樊渝江 National Engineering Research Center for Biomaterials Engineering Research Center of BiomaterialsSichuan UniversityChengdu 610064China

A novel ph-sensitive nanoparticle drug delivery system (DDS) derived fl om natural polysaccharide pullulan for doxorubicin (DOX) release was prepared.Pullulan was functionalized by successive carboxymethylization and amidation to introduce hydrazide groups.DOX was then grafted onto pullulan backbone through the ph-sensitive hydrazone bond to form a pullulan/DOX conjugate.This conjugate self-assembled to form nano-sized particles in aqueous solution as a result of the hydrophobic interaction of the DOX.Trans...

关键词： Natural polysaccharide ph-sensitive Nanoparticle drug delivery system Doxorubicin