Fabrication of Mesoporous SiO_(2)@CaSiO_(3) Hollow Spheres as Carriers for pH-sensitive Drug Delivery

作     者：YUAN Mingwei SHI Shunli LUO Yanping YU Ying WANG Shuhua CHEN Chao YUAN Mingwei;SHI Shunli;LUO Yanping;YU Ying;WANG Shuhua;CHEN Chao

作者机构：Key Laboratory of Jiangxi Province for Environment and Energy CatalysisCollege of ChemistryNanchang UniversityNanchang330031P.R.China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2022年第38卷第4期

页      面：999-1004页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 070301[理学-无机化学] 

基　　金：supported by the National Natural Science Foundation of China(No.21961021) the Natural Science Foundation of Jiangxi Province,China(No.20202ACB203001) 

主　　题：Hollow nano-sphere SiO_(2)@CaSiO_(3) Drug delivery pH-sensitive 

摘      要：Hollow mesoporous silica(HM-SiO_(2))was prepared by the improved stober *** this basis,HM-SiO_(2) was dispersed in an alkaline solution for surface ***,calcium source was introduced to combine with SiO_(3)^(2−) on the surface to form a CaSiO_(3) shell layer and an unprecedent SiO_(2)@CaSiO_(3) sphere with a hollow double-shell structure was *** as-synthesized SiO_(2)@CaSiO_(3) was characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),N_(2)-BET,IR and UV-Vis techniques,and its sustained release capacity of doxorubicin(DOX)loading was *** drug loading capacity can be achieved to 0.692 mg DOX/mg SiO_(2)@CaSiO_(3),exhibiting pH-responsivity under low pH conditions.