Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model
作者机构：Laboratory of Stem Cell and Tissue EngineeringOrthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Aesthetic SurgeryThe People’s Hospital of PengzhouChengduSichuan611930China Surgery of Spine and Spinal CordHenan Provincial People’s HospitalZhengzhouHenan450000China Department of Burn and Plastic SurgeryWest China HospitalSichuan UniversityChengduSichuan610041China Research Core Facility of West China HospitalSichuan UniversityChengduSichuan610041China Department of Medical Genetics and Prenatal DiagnosisWest China Second HospitalSichuan UniversityChengduSichuan610041China
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2022年第7卷第8期
页 面：443-455页
核心收录：
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
基 金：supported by the National Natural Science Foundation of China(Grant No.32171351,31771065) National Key Research and Development Program of China(Grant No.2017YFC1104702) the“1.3.5”Project for Disciplines of Excellence,West China Hospital,Sichuan University(Grant No.ZYJC18002)
主 题：Regenerative medicine Bladder tissue engineering Scaffold Antibody-conjugated
摘 要：The need for bladder reconstruction and side effects of cystoplasty have spawned the demand for the development of alternative material *** such as submucosa of small intestine(SIS)have been widely used as patches for bladder repair,but the outcomes are not fully *** capture stem cells in situ has been considered as a promising strategy to speed up the process of re-cellularization and *** this study,we have developed an anti-CD29 antibody-conjugated SIS scaffold(AC-SIS)which is capable of specifically capturing urine-derived stem cells(USCs)in situ for tissue repair and *** scaffold has exhibited effective capture capacity and sound *** vivo experiment proved that the AC-SIS scaffold could promote rapid endothelium healing and smooth muscle *** endogenous stem cell capturing scaffolds has thereby provided a new revenue for developing effective and safer bladder patches.
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