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Gastrointestinal complications after kidney transplantation

World Journal of Gastroenterology 2020年第38期26卷 5797-5811页

作者： Rossella Gioco Daniela Corona Burcin Ekser lidia puzzo Gaetano Inserra Flavia Pinto Chiara Schipa Francesca Privitera Pierfrancesco Veroux Massimiliano Veroux General Surgery Unit University Hospital of CataniaCatania 95123Italy Department of Biomedical and Biotechnological Sciences University of CataniaCatania 95123Italy Department of Surgery Indiana University School of MedicineIndianapolisIN 46202United States Pathology Unit Department of Medical and Surgical Sciences and Advanced TechnologiesUniversity of CataniaCatania 95123Italy Gastroenterology Unit Department of Clinical and Experimental MedicineUniversity of CataniaCatania 95100Italy Organ Transplant Unit University Hospital of CataniaCatania 95123Italy General Surgery Unit Organ Transplant UnitUniversity Hospital of CataniaCatania 95123Italy Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of CataniaCatania 95123Italy

Gastrointestinal complications are common after renal transplantation,and they have a wide clinical spectrum,varying from diarrhoea to post-transplant inflammatory bowel disease(IBD).Chronic immunosuppression may increase the risk of post-transplant infection and medication-related injury and may also be responsible for IBD in kidney transplant re-cipients despite *** the various forms of post-transplant colitis is challenging,since most have similar clinical and histological ***-related colitis are the most frequently encountered colitis after kidney transplantation,particularly those related to the chronic use of mycophenolate mofetil,while de novo IBDs are quite *** review will explore colitis after kidney transplantation,with a particular focus on different clinical and histological features,attempting to clearly identify the right treatment,thereby improving the final outcome of patients.

关键词： Inflammatory bowel disease Kidney transplantation Solid organ transplantation Crohn disease Ulcerative colitis Mycophenolate mofetil colitis Mycophenolate mofetil Colitis Cytomegalovirus

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Prevalence of celiac disease in adult patients with refractory functional dyspepsia:Value of routine duodenal biopsy

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World Journal of Gastroenterology 2008年第45期14卷 6948-6953页

作者： Emiliano Giangreco Cinzia D'agate Carmelo Barbera lidia puzzo Giuseppe Aprile Pietro Naso Giacomo Bonanno Alessandra Nicoletti Salvatore Incarbone Giuseppe Trama Antonio Russo Francesco Paolo Russo Department of Surgery Gastroenterology and Endoscopy Unit University of Catania Department of Surgical and Gastro-enterological Sciences Gastroenterology Section University of Padova

AIM: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gas-troenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional ***: Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duo-denal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber ***: The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD.

关键词： Celiac disease Endoscopy Biopsy Functional Dyspepsia

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Moro orange juice prevents fatty liver in mice

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World Journal of Gastroenterology 2012年第29期18卷 3862-3868页

作者： Federico Salamone Giovanni Li Volti Lucilla Titta lidia puzzo Ignazio Barbagallo Francesco La Delia Shira Zelber-Sagi Michele Malaguarnera Pier Giuseppe Pelicci Marco Giorgio Fabio Galvano Department of Internal Medicine University of Catania95123 CataniaItaly Department of Drug Sciences University of Catania95125 CataniaItaly Department of Experimental Oncology European Institute of Oncology20141 MilanItaly Department of Pathology University of Catania95123 CataniaItaly Department of Gastroenterology Tel Aviv Sourasky Medical CenterTel-Aviv 64239Israel

AIM:To establish if the juice of Moro,an anthocyaninrich orange,may improve liver damage in mice with diet-induced ***:Eight-week-old mice were fed a high-fat diet(HFD) and were administrated water or Moro juice for 12 *** morphology,gene expression of lipid transcription factors,and metabolic enzymes were ***:Mice fed HFD displayed increased body weight,insulin resistance and *** juice administration limited body weight gain,enhanced insulin sensitivity,and decreased serum triglycerides and total *** fed HFD showed liver steatosis associated with *** Moro juice markedly improved liver steatosis by inducing the expression of peroxisome proliferator-activated receptor-α and its target gene acylCoA-oxidase,a key enzyme of lipid ***,Moro juice consumption suppressed the expression of liver X receptor-α and its target gene fatty acid synthase,and restored liver glycerol-3-phosphate acyltransferase 1 ***:Moro juice counteracts liver steatogenesis in mice with diet-induced obesity and thus may represent a promising dietary option for the prevention of fatty liver.

关键词： Liver steatosis Anthocyanins Lipogenesis Lipid oxidation

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The effects of different electrode materials on seed germination of Solanum nigrum *** its Cd accumulation in soil

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Journal of Environmental Sciences 2022年第3期34卷 291-299页

作者： Lei Xu Huiping Dai lidia Skuza Shuhe Wei Key Laboratory of Pollution Ecology and Environment Engineering Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China College of Biological Science&Engineering Shaanxi Province Key Laboratory of Bio-resourcesShaanxi University of TechnologyHanzhong 723001China Institute of Biology Centre for Molecular Biology and BiotechnologyUniversity of SzczecinSzczecin 71-415Poland University of Chinese Academy of Sciences Beijing 100039China

The effects of different electrode on Solanum nigrum *** germination were *** result showed that germination percentage(GP)of seeds in treatment T2(titanium elec-trode)was 26.6%higher than in control(CK,without electric field).High potassium and calcium concentrations were beneficial for seed enzymatic activity in treatment T2,which could partly explain the increase in *** accumulation(μg/pot)in *** treated with any electric field was significantly higher(p<0.05)than in CK without electric ***-ically,Cd accumulation under the treatment T3(stainless steel electrode)was the highest both in roots and shoots;this accumulation in shoots and roots were 74.7%and 67.4%higher for stainless steel than in *** increase must have been associated with a higher Cd concentration in plants and did not exert a significant effect on the *** par-ticular,Cd concentrations in roots and shoots under stainless steel treatment were both significantly higher than in CK(p<0.05),which had to be related to the higher available Cd concentration in the soil in the middle ***,it could be attributed to al-tered soil pH and other soil ***,none of the biomasses were significantly affected(p<0.05)by different electrode materials compared to CK.

关键词： Cd contaminated soil Solanum nigrum L. DC electric field Electrode materials Seed germination

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Minimal silting modules and ring extensions

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Science China Mathematics 2022年第9期65卷 1775-1794页

作者： lidia Angeleri Hügel Weiqing Cao Dipartimento di Informatica Universitàdegli Studi di VeronaVerona I-37134Italy School of Mathematics and Statistics Jiangsu Normal UniversityXuzhou 221116China

Ring epimorphisms often induce silting modules and cosilting modules,termed minimal silting or minimal *** aim of this paper is ***,we determine the minimal tilting and minimal cotilting modules over a tame hereditary *** particular,we show that a large cotilting module is minimal if and only if it has an adic module as a direct ***,we discuss the behavior of minimality under ring *** show that minimal cosilting modules over a commutative noetherian ring extend to minimal cosilting modules along any flat ring *** results are obtained for commutative rings of small homological dimensions.

关键词： minimal silting modules ring epimorphisms ring extensions minimal cosilting modules tame hereditary algebras

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Temporal evolution of charged and neutral nanoparticle concentrations during atmospheric new particle formation events and its implications for ion-induced nucleation

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Frontiers of Environmental Science & Engineering 2016年第5期10卷 143-151页

作者： E. Rohan Jayaratne Buddhi Pushpawela lidia Morawska International Laboratory for Air Quality and Health Queensland University of Technology Brisbane QLD 4001 Australia

Time series of nanoparticle number concentration during new particle formation （NPF） events in the urban environment of Brisbane, Australia, showed that the formation of charged particles often occurred before that of neutral particles. We monitored 241 days during the calendar year 2012 over which NPF events were observed on 108 days. We studied the times at which the charged and neutral particle concentrations in the size range 1.8-3.2 nm reached their peak values and found that they were clearly different in 50 events with the peak neutral particle concentration lagging behind the charged particle concentration during 42 of these events with a mean time lag of 245-12 rain. While the charged particles were more likely to form before the neutral particles, once lbrmed, the growth rate of the particles did not depend on their charge. While ion-induced nucleation is not the dominant mechanism of NPF in the atmosphere, our observations suggest that the presence of ions in the atmosphere plays a role that cannot be ignored.

关键词： Charged particles Cluster ions Secondary particles Environmental pollution

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Two-proton sequential decay from excited states of ^(18)Ne

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Nuclear Science and Techniques 2013年第5期24卷 89-91页

作者： YU Ningal MAGLIONE Enrico FERREIRA lidia Institute of Particle Physics Huazhong Normal University Dipartimento di Fisica "G.Galilei" PadovaItaly and Istituto Nazionale di Fisica Nucleare Centro de Física das Interac es Fundamentais and Departmento de FísicaInstituto Superior Técnico

Two-proton radioactivity from18Ne is discussed in terms of sequential *** branch ratios for oneproton emission from excited states are calculated,which including spectroscopic factors,obtained from a Shellmodel calculation with realistic *** branch ratios show that the two-proton emission from the 1-state of 18Ne at 7.94 MeV is most likely to go through the sequential *** same mechanism is discussed for other excited states at higher energy by different interactions.

关键词：质子衰变激发态质子发射分支比放射性壳模型衰减计算

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Soil particle size range correction for improved calibration relationship between the laser-diffraction method and sieve-pipette method

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Pedosphere 2021年第1期31卷 134-144页

作者： Weiwen QIU Wei HU Denis CURTIN lidia MOTOI New Zealand Institute for Plant&Food Research Limited Private Bag 4704Christchurch 8140New Zealand

Particle size fraction(clay, silt, and sand) is an important characteristic that influences several soil functions. The laser-diffraction method(LDM) provides a fast and cost-effective measurement of particle size distribution, but the results usually differ from those obtained by the traditional sieve-pipette method(SPM). This difference can persist even when calibration is applied between the two methods. This partly relates to the different size ranges of particles measured by the two methods as a result of different operational principles, i.e., particle sedimentation according to Stokes’ Law vs. Mie theory for laser beam scattering. The objective of this study was to identify particle size ranges of LDM equivalent to those measured by SPM and evaluate whether new calibration models based on size range correction can be used to improve LDM-estimated particle size fractions, using 51 soil samples with various texture collected from five soil orders in New Zealand. Particle size distribution was determined using both LDM and SPM. Compared with SPM, original data from LDM underestimated the clay fraction(< 2 μm), overestimated the silt fraction(2–53 μm), but provided a good estimation of the sand fraction(53–2 000 μm).Results from three statistical indices, including Pearson’s correlation coefficient, slope, and Lin’s concordance correlation coefficient, showed that the size ranges of < 2 and 2–53 μm defined by SPM corresponded with the < 5 and 5–53 μm size ranges by LDM, respectively. Compared with the traditional calibration(based on the same particle size ranges), new calibration models(based on the corrected size ranges of these two methods) improved the estimation of clay and silt contents by LDM. Compared with soil-specific models(i.e., different models were developed for different soils), a universal model may be more parsimonious for estimating particle size fractions if the samples to be assessed represent multiple soil orders.

关键词： laser diffraction Lin’s concordance correlation coefficient particle size distribution Pearson’s correlation coefficient sedimentation method soil separate soil texture

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The airborne contagiousness of respiratory viruses:A comparative analysis and implications for mitigation

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Geoscience Frontiers 2022年第6期13卷 257-264页

作者： Alex Mikszewski Luca Stabile Giorgio Buonanno lidia Morawska International Laboratory for Air Quality and Health Queensland University of TechnologyBrisbaneQueenslandAustralia CIUS Building Performance Lab The City University of New YorkNew YorkNYUSA Department of Civil and Mechanical Engineering University of Cassino and Southern LazioCassinoFRItaly Global Centre for Clean Air Research(GCARE) Department of Civil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUnited Kingdom

The infectious emission rate is a fundamental input parameter for airborne transmission risk assessment,but data are limited due to reliance on estimates from chance superspreading *** study assesses the strength of a predictive estimation approach developed by the authors for SARS-CoV-2 and uses novel estimates to compare the contagiousness of respiratory *** applied the approach to SARS-CoV-1,SARS-CoV-2,MERS,measles virus,adenovirus,rhinovirus,coxsackievirus,seasonal influenza virus and Mycobacterium tuberculosis(TB)and compared quanta emission rate(ER)estimates to literature *** calculated infection risk in a prototypical classroom and barracks to assess the relative ability of ventilation to mitigate airborne *** median standing and speaking ERestimate for SARS-CoV-2(2.7 quanta h)is similar to active,untreated TB(3.1 quanta h),higher than seasonal influenza(0.17 quanta h-1),and lower than measles virus(15 quanta h).We calculated event reproduction numbers above 1 for SARS-CoV-2,measles virus,and untreated TB in both the classroom and barracks for an activity level of standing and speaking at low,medium and high ventilation rates of 2.3,6.6 and 14 L per second per person(L sp),*** predictive ERestimates are consistent with the range of values reported over decades of *** congregate settings,current ventilation standards are unlikely to control the spread of viruses with upper quartile ERqvalues above 10 quanta h,such as SARS-CoV-2,indicating the need for additional control measures.

关键词： SARS-CoV-2(COVID-19)airborne transmission Quanta emission rate Ventilation Measles Influenza

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Genes for RNA-binding proteins involved in neuralspecific functions and diseases are downregulated in Rubinstein-Taybi iNeurons

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Neural Regeneration Research 2022年第1期17卷 5-14页

作者： lidia Larizza Luciano Calzari Valentina Alari Silvia Russo Cytogenetics and Molecular Genetics Laboratory IRCCS Istituto Auxologico ItalianoMilanoItaly

Taking advantage of the fast-growing knowledge of RNA-binding proteins(RBPs)we review the signature of downregulated genes for RBPs in the transcriptome of induced pluripotent stem cell neurons(iNeurons)modelling the neurodevelopmental Rubinstein Taybi Syndrome(RSTS)caused by mutations in the genes encoding CBP/p300 *** discuss top and functionally connected downregulated genes sorted to“RNA processing”and“Ribonucleoprotein complex biogenesis”Gene Ontology *** first set of downregulated RBPs includes members of hnRNHP(A1,A2B1,D,G,H2-H1,MAGOHB,PAPBC),core subunits of U small nuclear ribonucleoproteins and Serine-Arginine splicing regulators families,acting in precursor messenger RNA alternative splicing and *** with literature findings on reduced transcript levels of serine/arginine repetitive matrix 4(SRRM4)protein,the main regulator of the neural-specific microexons splicing program upon depletion of Ep300 and Crebbp in mouse neurons,RSTS iNeurons show downregulated genes for proteins impacting this *** link downregulated genes to neurological disorders including the new HNRNPH1-related intellectual disability syndrome with clinical overlap to *** set of downregulated genes for Ribosome biogenesis includes several components of ribosomal subunits and nucleolar proteins,such NOP58 and fibrillarin that form complexes with snoRNAs with a central role in guiding post-transcriptional modifications needed for rRNA *** nucleolar proteins are“dual”players as fibrillarin is also required for epigenetic regulation of ribosomal genes and conversely NOP58-associated snoRNA levels are under the control of NOP58 interactor BMAL1,a transcriptional regulator of the circadian *** downregulated genes for“dual specificity”RBPs such as RUVBL1 and METTL1 highlight the links between chromatin and the RBP-ome and the contribution of perturbations in their cross-talk to *** underline the hub position o

关键词： alternative splicing CBP/p300 chromatin regulators downregulated genes induced pluripotent stem cell-neurons neurodevelopmental disorders ribosome biogenesis RNA-binding proteins RNASeq Rubinstein-Taybi

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